Evaluation of osteoinduction properties of the demineralized bovine foetal growth plate powder as a new xenogenic biomaterial in rat

Bigham, A. S.; Shadkhast, Mohammad; Sadegh, Amin Bigham; Shafiei, Zahra; Lakzian, Amir; Khalegi, M. R.

doi:10.1016/j.rvsc.2010.12.001

Cited by 15 publications

(23 citation statements)

References 31 publications

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“…The biggest disadvantage of fibrotic healing is that the fibrotic tissue formed does not function like bone tissue and is not shear resistant. Since the fibrotic tissue is not firm like bone tissue structurally, it cannot heal the defects and leads to problems such as pseudarthrosis, encapsulation, and nonunion (23,24).…”

Section: Discussionmentioning

confidence: 99%

“…The rabbits were anesthetized first with intramuscular injection and premedication of 5 mg/kg of xylazine hydrochloride (Rompun, 23.32 mg/mL, Bayer, Turkey), and then with the intramuscular application of 50 mg/kg of ketamine hydrochloride (Ketalar, 50 mg/mL, Eczacıbaşı, Turkey). After anesthesia, the right back legs of the rabbits were shaved and disinfected.…”

Section: Anesthesia Techniquementioning

confidence: 99%

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Research of the effects of autologous cancellous bone graft and hyaluronic acidon the healing of bone defects experimentally induced in rabbits

Sağliyan¹,

Han²,

Karabulut³

et al. 2016

Turk J Vet Anim Sci

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Section: Discussionmentioning

confidence: 99%

Section: Anesthesia Techniquementioning

confidence: 99%

Research of the effects of autologous cancellous bone graft and hyaluronic acidon the healing of bone defects experimentally induced in rabbits

Sağliyan¹,

Han²,

Karabulut³

et al. 2016

Turk J Vet Anim Sci

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“…More recently another study showed the ectopic osteoinductive properties of calf ). More recently another study showed the ectopic osteoinductive properties of calf fetal growth plate in a rat sub-muscular model ( fetal growth plate in a rat sub-muscular model (BIGHAM et al, 2011BIGHAM et al, 2011. This study has been ).…”

Section: Introduction Introductionmentioning

confidence: 72%

“…Recently a study indicated that satisfactory ectopic bone formation occurred in a Recently a study indicated that satisfactory ectopic bone formation occurred in a submuscular rat model, with a xenogeneic demineralized bovine fetal growth plate and submuscular rat model, with a xenogeneic demineralized bovine fetal growth plate and complications were not identifi ed ( complications were not identifi ed (BIGHAM et al, 2011BIGHAM et al, 2011. Also, during two previous studies ).…”

Section: Discussion Discussionmentioning

confidence: 99%

Demineralized calf foetal growth plate effects on experimental bone healing

Shadkhast

Bigham-Sadegh

2011

Bone

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T he following study was designed to evaluate demineralized calf foetal growth plate (DCFGP) effects T he following study was designed to evaluate demineralized calf foetal growth plate (DCFGP) effects on bone healing process. A critical size defect (10 mm) was created in the radial diaphysis of 20 rabbits and on bone healing process. A critical size defect (10 mm) was created in the radial diaphysis of 20 rabbits and then supplied with DCFGP (treatment group, n = 10) or the defect was left empty (control group, n = 10). then supplied with DCFGP (treatment group, n = 10) or the defect was left empty (control group, n = 10). Radiographs of each forelimb were taken postoperatively on the 1 Radiographs of each forelimb were taken postoperatively on the 1 st st day and at the 2 day and at the 2 nd nd , 4 , 4 th th , 6 , 6 th th and 8 and 8 th th weeks post weeks post injury to evaluate bone formation, union and remodeling of the defect. The operated radiuses were removed injury to evaluate bone formation, union and remodeling of the defect. The operated radiuses were removed on the 56 on the 56 th th postoperative day and were evaluated for histopathological criteria. This study demonstrated that postoperative day and were evaluated for histopathological criteria. This study demonstrated that DCFGP, as a xenogenic biomaterial, could promote bone regeneration in critical size defects with a high DCFGP, as a xenogenic biomaterial, could promote bone regeneration in critical size defects with a high regenerative capacity, and could be an attractive alternative for reconstruction of the major diaphyseal defects regenerative capacity, and could be an attractive alternative for reconstruction of the major diaphyseal defects of the long bones in animal models. of the long bones in animal models.

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“…Bone healing is not sufficient in large bone defects and may be complicated. Under these circumstances, the autografts are the most popular method for bone replacement [4][5][6]. In some instances, autografts cannot be used for filling such large defects.…”

Section: Introductionmentioning

confidence: 99%

Present Strategies for Critical Bone Defects Regeneration

Kheirallah¹,

Almeshaly²

2016

Oral Health Case Reports

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A critical size bone defect may arise due to severe trauma or tumors where a large portion of the bone is removed. In some instances, autografts cannot be used for filling such large defects. Allografts may be used to reconstruct large bone defects, but these grafts may not incorporate in the healing response. Consequently, it is still a challenge for reconstructive surgery to reconstruct large bone defects. A variety of treatment strategies have been progressed to promote the healing response and close the bone defects. Micro and nano particles (MNPs) technology is a newer option than traditional grafts, which may defeat many limitations of the bone graft usage. However, there are still no well approved treatment strategies to override all the expected requirements. Due to the existence of variety strategies for treatment of critical size bone defects, this impartial review, highlights on the techniques and strategies that have been accomplished to anatomize the complicated treatment problems of large bone defect healing, the limitations of therapeutic relevant biodegradable materials, and service the regeneration of large bone defects.

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Evaluation of osteoinduction properties of the demineralized bovine foetal growth plate powder as a new xenogenic biomaterial in rat

Cited by 15 publications

References 31 publications

Research of the effects of autologous cancellous bone graft and hyaluronic acidon the healing of bone defects experimentally induced in rabbits

Research of the effects of autologous cancellous bone graft and hyaluronic acidon the healing of bone defects experimentally induced in rabbits

Demineralized calf foetal growth plate effects on experimental bone healing

Present Strategies for Critical Bone Defects Regeneration

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