Evaluation of osseointegration of dental implants coated with collagen, chondroitin sulphate and BMP-4: an animal study

Stadlinger, Bernd; Pilling, Eckart; Huhle, Matthias; Mai, Ronald; Bierbaum, Susanne; Scharnweber, Dieter; Kuhlisch, Eberhard; Loukota, R.A.; Eckelt, Uwe

doi:10.1016/j.ijom.2007.05.024

Cited by 85 publications

(61 citation statements)

References 35 publications

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“…Immobilized monosulfated HA facilitated the proliferation and TNAP activity of human osteoblasts in the same manner as a coating with collagen [97]. Implant coating with collagen fibrils and CS or CS-PGs promotes adhesion and differentiation of osteoblasts and osseointegration [87,[107][108][109][110][111][112].…”

Section: Gags and Osteoblastsmentioning

confidence: 99%

Regenerative potential of glycosaminoglycans for skin and bone

et al. 2011

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To meet the growing need for tissue replacement materials for our aging population, the development of new adaptive biomaterials is essential. The tissues with the highest demand for implant materials are skin and bone. These tissues share various similarities, including signaling pathways and extracellular matrix composition. Glycosaminoglycans such as hyaluronan and chondroitin sulfate are the major organic extracellular matrix components. They modulate the attraction of skin and bone precursor cells and their subsequent differentiation and gene expression and regulate the action of proteins essential to bone and skin regeneration. The precise action of glycosaminoglycans varies according to their structural composition mainly in respect to the degree of sulfation and polymer length. Changes in the glycosaminoglycan composition are frequently seen in physiological and pathological remodeling processes, such as bone formation or scaring. Here, we review the current state of knowledge of how the most common glycosaminoglycan, chondroitin sulfate and hyaluronan, interact with bone and skin cells, and summarize their potential in tissue engineering for skeletal and skin diseases.

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Section: Gags and Osteoblastsmentioning

confidence: 99%

Regenerative potential of glycosaminoglycans for skin and bone

et al. 2011

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“…Hyaluronic acid (Davidenko et al, 2010) Matrix, membrane, hydrogel, fibers Silk fibroin (Zhou et al, 2010) Membrane, fibers, matrix, microtubes Chondroitin-6-suphate (Stadlinger et al, 2008) Tube, matrix Elastin Tube, film, fibers, matrix Alginate (Sang et al, 2011) Spongious, filler for bone, Chitosan (Sionkowska et al, 2004) Matrix, membrane, tubular graft, nanofibers, hydrogel, Heparin (Stamov et al, 2008) Matrix Collagensynthetic polymer Poly-L-lactide (PLLA) (Chen et al, 2006) Coating for composite Poly-lactic-co-glycolic-acid (PLGA) (Wen et al, 2007) Fibers, matrix, coated tube ε-caprolactone (Schnell et al, 2007) Nanofibers Poly(ethylene-glycol) (PEG) Films, fibers…”

Section: Type Of Composite Type Of Component From Composite Compositementioning

confidence: 99%

Collagen-Based Drug Delivery Systems for Tissue Engineering

Albu¹,

Titorencu²,

Ghica³

2011

Biomaterials Applications for Nanomedicine

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“…15 One reason may be difficulties in keeping a good oral hygiene in pigs, which is much more complicated than in monkeys or dogs. Another reason may be the oral flora of pigs.…”

Section: Staphylococcus Aureusmentioning

confidence: 99%

A pilot study: microbiological conditions of the oral cavity in minipigs for peri-implantitis models

et al. 2011

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As peri-implantitis is an emerging problem, the development of validated animal models is mandatory. The aim of this pilot study was to provide a first step in describing the normal oral flora of minipigs. In five minipigs, samples of the oral flora were collected with sterile cotton swabs from the buccal gingiva of the lower jaw. Two swabs per animal were collected, followed by bacterial isolation under both aerobe and anaerobe conditions. Microbiological analyses included biochemical tests, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and 16S rDNA gene sequence analysis. A total of 61 taxa were detected, 14-21 different bacterial taxa from each minipig. Among the Gram-positive cocci, mainly staphylococcal and streptococcal species were identified. Different Actinomyces species were the most abundant taxa in the group of Gram-positive rods. Among the anaerobic bacteria, the Gram-negative genera Fusobacterium, Bacteroides and Prevotella were the most often observed taxa. This is the first study which begins to describe the normal oral flora in minipigs in cultures to allow for the detection of a broad spectrum. Several bacterial species identified are different from human ones. No specific species for peri-implantitis could be detected in that healthy sample.

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Evaluation of osseointegration of dental implants coated with collagen, chondroitin sulphate and BMP-4: an animal study

Cited by 85 publications

References 35 publications

Regenerative potential of glycosaminoglycans for skin and bone

Regenerative potential of glycosaminoglycans for skin and bone

Collagen-Based Drug Delivery Systems for Tissue Engineering

A pilot study: microbiological conditions of the oral cavity in minipigs for peri-implantitis models

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