Collagen-Based Drug Delivery Systems for Tissue Engineering

Albu, Mădălina Georgiana; Titorencu, Irina; Ghica, Mihaela Violeta

doi:10.5772/22981

Cited by 11 publications

(9 citation statements)

References 133 publications

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“…Collagen matrices have the ability to absorb large amounts of exudates from wounds. This favors the formation of a biodegradable gel or sheet on the surface of the wound that maintains a humid environment, promotes healing, and provides protection against external mechanical forces [46]. Collagen sponges possess adequate characteristics for tissue regeneration due to their high porosity, permeability, low toxicity, cell adhesion, and biocompatibility [47].…”

Section: Scaffoldsmentioning

confidence: 99%

Tilapia (Oreochromis aureus) Collagen for Medical Biomaterials

Valenzuela-Rojo¹,

López‐Cervantes²,

Sánchez‐Machado³

2018

Seaweed Biomaterials

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Collagen is a natural polymer widely used in pharmaceutical products and nutritional supplement due to its biocompatibility and biodegradability. Collagen is a fibrous protein that supports various tissues, and its primary structure is formed by repeated units of glycineproline-hydroxyproline. Traditional sources of collagen, such as bovine and pig skins or chicken waste, limit their use due to the dangers of animal-borne diseases. Thus, marine animals are an alternative for the extraction of collagen. The common name of Oreochromis aureus is tilapia, widely cultivated for sale as frozen fillets. During its processing, a large amount of collagen-rich wastes are generated. Therefore, the objective of this book chapter is to prove the potential of tilapia skin as an alternative source of collagen for the elaboration of biomaterials. Additionally to the literature review, experimental results of the extraction and characterization of tilapia skin collagen for use in medical dressings are presented.

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Section: Scaffoldsmentioning

confidence: 99%

Tilapia (Oreochromis aureus) Collagen for Medical Biomaterials

Valenzuela-Rojo¹,

López‐Cervantes²,

Sánchez‐Machado³

2018

Seaweed Biomaterials

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“…In particular, collagen is the main fibrous protein of human body and, within ECM, provides cell migration, adhesion, and differentiation, promoting angiogenesis [ 7 , 8 , 9 ]. Due to its excellent biocompatibility and biodegradability and to its weak antigenicity, collagen represents one of the most used natural biomaterials in skin replacement, bone substitutes, and artificial blood vessels and valves [ 10 , 11 ]. It can be processed by cross-linking, freeze drying, or electrospinning to obtain hydrogels, membranes, matrices, and fibers [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…Due to its excellent biocompatibility and biodegradability and to its weak antigenicity, collagen represents one of the most used natural biomaterials in skin replacement, bone substitutes, and artificial blood vessels and valves [ 10 , 11 ]. It can be processed by cross-linking, freeze drying, or electrospinning to obtain hydrogels, membranes, matrices, and fibers [ 11 ]. Electrospinning of collagen has been widely studied in literature [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

“…A relevant role has been claimed to the presence in collagen of chemotactic sequences able to stimulate the formation of granulation tissue essential for wound healing. It is also worth noting that the presence of both triple helical integrity and the RGD (Arg-Gly-Asp) ligand explosion are selectively recognized by specific integrin on the cellular membrane, leading to cell attachment [ 11 , 18 , 19 , 20 , 21 , 22 ]. Different wound dressings based on collagen have been for this reason proposed to cover burns and wounds, as they help in promoting cell growth and activating inflammatory phase of wound healing [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

“…This limit can be properly overcome by the combination of PCL with either collagen or gelatin [ 20 , 24 , 25 ]. Therefore, a synergistic effect is achieved, and this combination not only allows to significantly decrease PCL hydrophobicity, but also has a favorable influence on cellular response of the scaffold [ 11 , 17 , 22 ]. In previous studies collagen/PCL combination has been electrospun by using organic, toxic, and expensive solvents such as 1,1,1,3,3,3-hexafluoro-2-propanol (HFP) or 2,2,2-trifluoroethanol (TFE) [ 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

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Collagen/PCL Nanofibers Electrospun in Green Solvent by DOE Assisted Process. An Insight into Collagen Contribution

et al. 2020

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Collagen, thanks to its biocompatibility, biodegradability and weak antigenicity, is widely used in dressings and scaffolds, also as electrospun fibers. Its mechanical stability can be improved by adding polycaprolactone (PCL), a synthetic and biodegradable aliphatic polyester. While previously collagen/PCL combinations were electrospun in solvents such as hexafluoroisopropanol (HFIP) or trifluoroethanol (TFE), more recently literature describes collagen/PCL nanofibers obtained in acidic aqueous solutions. A good morphology of the fibers represents in this case still a challenge, especially for high collagen/PCL ratios. In this work, thanks to preliminary rheological and physicochemical characterization of the solutions and to a Design of Experiments (DOE) approach on process parameters, regular and dimensionally uniform fibers were obtained with collagen/PCL ratios up to 1:2 and 1:1 w/w. Collagen ratio appeared relevant for mechanical strength of dry and hydrated fibers. WAXS and FTIR analysis showed that collagen denaturation is related both to the medium and to the electrospinning process. After one week in aqueous environment, collagen release was complete and a concentration dependent stimulatory effect on fibroblast growth was observed, suggesting the fiber suitability for wound healing. The positive effect of collagen on mechanical properties and on fibroblast biocompatibility was confirmed by a direct comparison of nanofiber performance after collagen substitution with gelatin.

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Beneficial use of animal hides for abattoir and tannery waste management: a review of unconventional, innovative, and sustainable approaches

Patel

Munir

2021

Environ Sci Pollut Res

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Collagen-Based Drug Delivery Systems for Tissue Engineering

Cited by 11 publications

References 133 publications

Tilapia (Oreochromis aureus) Collagen for Medical Biomaterials

Tilapia (Oreochromis aureus) Collagen for Medical Biomaterials

Collagen/PCL Nanofibers Electrospun in Green Solvent by DOE Assisted Process. An Insight into Collagen Contribution

Beneficial use of animal hides for abattoir and tannery waste management: a review of unconventional, innovative, and sustainable approaches

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