Evaluation of Ocular Surface Damage and Dry Eye Status in Chronic Hepatitis C at Different Stages of Hepatic Fibrosis

Gümüş, Koray; Yurci, Alper; Mirza, Ertugrul; Arda, Hatice; Öner, Ayşe; Topaktas, Duygu; Karaküçük, Sarper

doi:10.1097/ico.0b013e3181a0a3c5

Cited by 21 publications

(6 citation statements)

References 19 publications

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“…36 The Oxford Grade is one of the staining scales more widely used in the clinic for corneal staining classification. [37][38][39] Although conjunctival staining < 2 in the Efron grading was suggested to be not considered clinically significant it may affect the level of comfort in contact lens wearers. 3,40 In concordance with present results, previous studies have found an increase in the corneal and conjunctival staining during monthly contact lens use during six months 27 or with a monthly and daily lenses combination during two months.…”

Section: Discussionmentioning

confidence: 99%

Changes of symptomatology, tear film and ocular surface integrity one week during Somofilcon-A and Omafilcon-A lens wear

Pena-Verdeal

Noya-Padin

Losada-Oubiña

et al. 2022

European Journal of Ophthalmology

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Purpose Clinicians play a key role in prescribing contact lenses that best suited for fitting which materials had an impact on ocular surface parameters. The present study aimed to evaluate the impact on symptomatology, tear film dynamics and ocular surface integrity of a silicone-hydrogel (Somofilcon-A) and a hydrogel (Omafilcon-A) lens before and after wearing for one week in contact lens neophyte participants. Methods A Somofilcon-A and Omafilcon-A were randomly fitted to one or other the eye on an initial group of 28 participants. Subjects were scheduled for three sessions: basal session previous fitting, second session after 4-wear hours, and final session after 7-wear days for up to 10 h. In each session, CLDEQ-8, tear meniscus height and hyperemia with and without lenses, as well as lipid layer thickness and corneal/conjunctival staining without lenses were assessed. Values were compared between lenses and sessions. Results In intrasession comparison, there were no differences in any parameter between materials on any session with or without lenses (all p≥0.176), except on the conjunctival staining where values obtained during Somofilcon-A wear (all p ≤ 0.006). In intersession analysis, CLDEQ-8 score, tear meniscus height and lipid layer thickness showed a statistical difference during both materials wear (all p ≤ 0.009), while conjunctival hyperemia does not (p = 0.237); corneal staining showed differences during Omafilcon-A wear (p = 0.037), contrary to conjunctival staining which showed differences only during Somofilcon-A wear (p < 0.001). Conclusion Contact lenses wear had an impact on ocular parameters that have some specific influences of the material on which lenses were manufactured.

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Section: Discussionmentioning

confidence: 99%

Changes of symptomatology, tear film and ocular surface integrity one week during Somofilcon-A and Omafilcon-A lens wear

Pena-Verdeal

Noya-Padin

Losada-Oubiña

et al. 2022

European Journal of Ophthalmology

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“…Recently, a more detailed study by Gumus et al reported a higher frequency of changes in all Ocular Surface Disease Index (OSDI, Schirmer I, Schirmer II, and BUT) scores in patients with chronic hepatitis C than in noninfected individuals in an age-and sex-matched sample (42) .…”

Section: Ocular Surfacementioning

confidence: 99%

“…The pathogenesis of dry eye in patients with HCV in fection involves the destruction of glandular cells, possibly by antigenic reactions to immunocomplexes produced by viral antigens and specific antibodies or by the direct action of the virus (32,42) . Other possibilities suggest that lymphocytic infiltration of the lacrimal gland (45,46) or modification of corneal sensitivity occurs due to sensory alterations in the trigeminal nerve, reducing tear production (43) .…”

Section: Ocular Surfacementioning

confidence: 99%

O olho na hepatite C: uma revisão

Bertrand

Gomes

et al. 2019

Arquivos Brasileiros De Oftalmologia

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| This review aims to caution ophthalmologists about the ocular consequences leading to the diagnosis of hepatitis C virus infection. In addition, in this context, the effects of old and new drugs are discussed in the ophthalmological setting. The importance of early diagnosis and the curative treatment of the disease has been reported in the national and international literature, demonstrating that its progression has important implications for daily clinical and surgical ophthalmological practice. Despite the scarcity of studies on new direct-acting antiviral drugs, fewer side effects of these drugs have been shown when compared with conventional interferon treatment with or without ribavirin. The ophthalmologist's risk of becoming infected, as demonstrated by the presence of the virus in ocular structures, and the possibility of contamination, is also discussed.Keywords: Hepatitis C/ complications; Hepatitis C/drug therapy; Interferon/therapeutic use; Direct-acting antiviral drugs RESUMO | Esta revisão objetiva alertar os oftalmologistas sobre as consequências oculares que levam ao diagnóstico da infecção pelo vírus da Hepatite C. Além disso, neste contexto, os efeitos de drogas antigas e novas são discutidos no cenário oftalmológico. A importância do diagnóstico precoce e do tratamento curativo da doença tem sido relatada na literatura nacional e internacional, demonstrando que sua progressão tem implicações importantes para a prática oftalmológica diária. Apesar da escassez de estudos sobre novos medicamentos antivirais de ação direta, foram demonstrados menos efeitos colaterais desses medicamentos quando comparados ao tratamento convencional com interferon, com ou sem ribavirina associado ou não à rivabirina. O risco do oftalmologista de se infectar, como demonstrado pela presença do vírus nas estruturas oculares, e a possibilidade de contaminação, também é discutido.Descritores: Hepatite C/complicações; Hepatite C/tratamento farmacológico; Interferon/uso terapêutico; Drogas antivirais de ação direta

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“…Measuring the ne structure of the retina and choroid (11,12,13) has demonstrated strengths in diagnosing and re ecting disease progression in conditions such as optic neuritis ( 14), Alzheimer's disease (15), diabetic retinopathy (16), thyroid-related eye disease (17), and Parkinson's disease (18). However, the characterization of retinopathy in cirrhosis remains limited, and previous studies have documented ocular pathologies associated with cirrhosis, such as dry eye (19), vitamin A de ciency (20) and color blindness (21). These ocular pathologies, including elevated complement levels and immune complex deposition, as well as circulatory abnormalities and other contributing factors, have been linked to diseases of the immune system.…”

Section: Introductionmentioning

confidence: 99%

A novel approach: exploring the potential of retinal thickness and microvascular alterations for diagnosing cirrhosis

Li,

Zou,

Jin

et al. 2024

Preprint

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Background: The objective of this study was to investigate the correlation between fundus alterations and cirrhosis through the use of optical coherence tomography angiography (OCTA). Methods: This study involved 17 patients with cirrhosis (34 eyes) and 17 healthy controls (HCs; 34 eyes). The OCTA fundus data were segmented into various layers and regions and categorized according to the subzones of the Early Treatment Diabetic Retinopathy Study for comparison. Results: Patients with cirrhosis had a lower full retinal thickness (RT) in the IS, OS, and ON regions than did healthy controls (HCs) (P < 0.001), and the RT was also lower in the IN and central regions (p<0.05). Additionally, the inner layer RT was lower in the IS, OS, IT, and OT regions in patients with cirrhosis (P < 0.05), and the outer layer RT was lower in the IS, IN, and ON regions in patients with cirrhosis than in HCs (P < 0.05). The ROC curve of the inner RT of the IS region showed a greater sensitivity to the pathological changes associated with the disease, with an AUC of 0.9324 (95% CI: 0.8665-0.9983). Furthermore, compared with HCs, patients with cirrhosis exhibited significantly lower superficial vessel density (SVD) in the IS, OS, IT, and OT regions (P < 0.001) and lower SVD density in the ON and central regions (P < 0.05). The AUC for the IT region was 0.9429 (95% CI: 0.8928–0.9930), indicating good diagnostic sensitivity. Conclusion: The RT and SVD of specific subregions in the macular retina of patients with cirrhosis were lower than those in the macular retina of HCs. OCTA measurement could be a valuable aid for imaging in cirrhosis patients.

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Evaluation of Ocular Surface Damage and Dry Eye Status in Chronic Hepatitis C at Different Stages of Hepatic Fibrosis

Abstract: Patients with chronic hepatitis C, especially those with advanced stages of hepatic fibrosis, were more likely to exhibit severe ocular surface damage and signs of dry eye.

Cited by 21 publications

References 19 publications

Changes of symptomatology, tear film and ocular surface integrity one week during Somofilcon-A and Omafilcon-A lens wear

Changes of symptomatology, tear film and ocular surface integrity one week during Somofilcon-A and Omafilcon-A lens wear

O olho na hepatite C: uma revisão

A novel approach: exploring the potential of retinal thickness and microvascular alterations for diagnosing cirrhosis

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