Changes of symptomatology, tear film and ocular surface integrity one week during Somofilcon-A and Omafilcon-A lens wear

Abstract

Purpose Clinicians play a key role in prescribing contact lenses that best suited for fitting which materials had an impact on ocular surface parameters. The present study aimed to evaluate the impact on symptomatology, tear film dynamics and ocular surface integrity of a silicone-hydrogel (Somofilcon-A) and a hydrogel (Omafilcon-A) lens before and after wearing for one week in contact lens neophyte participants. Methods A Somofilcon-A and Omafilcon-A were randomly fitted to one or other the eye on an initial group of 28 participants. Subjects were scheduled for three sessions: basal session previous fitting, second session after 4-wear hours, and final session after 7-wear days for up to 10 h. In each session, CLDEQ-8, tear meniscus height and hyperemia with and without lenses, as well as lipid layer thickness and corneal/conjunctival staining without lenses were assessed. Values were compared between lenses and sessions. Results In intrasession comparison, there were no differences in any parameter between materials on any session with or without lenses (all p≥0.176), except on the conjunctival staining where values obtained during Somofilcon-A wear (all p ≤ 0.006). In intersession analysis, CLDEQ-8 score, tear meniscus height and lipid layer thickness showed a statistical difference during both materials wear (all p ≤ 0.009), while conjunctival hyperemia does not (p = 0.237); corneal staining showed differences during Omafilcon-A wear (p = 0.037), contrary to conjunctival staining which showed differences only during Somofilcon-A wear (p < 0.001). Conclusion Contact lenses wear had an impact on ocular parameters that have some specific influences of the material on which lenses were manufactured.

Assessing neophyte response to daily disposable silicone hydrogel contact lenses: A randomised clinical trial investigation over one month

“…com) that incorporates silicone monomers, N-vinylpyrrolidone and trimethylsiloxane, and were approved for distribution by the United States Food and Drug Administration (FDA). 14,22 The properties of these CLs were 56% water content, 8.6mm base curve, 14.1 mm diameter, Dk/t 86 • 10 −9 cm/s • mL O 2 /mL • mmHg and modulus of 0.5 MPa. These lenses were selected for the current investigation because they are available worldwide and represent a cost-effective daily disposable silicone-hydrogel CL option.…”

“…13 The use of CLs also alters tear film stability and tear volume, with decreased values being observed after CL removal. [14][15][16] Following the suggestion made by the TFOS CLD workshop, this randomised clinical trial aimed to assess the impact of a daily disposable silicone-hydrogel CL (somofilcon A) on symptoms, tear film dynamics and ocular surface integrity, when compared with non-CL wearers over the course of a month, paying special attention to changes in LWE and its potential implications for CLD.…”

Comparison Between Ocular Biometric Parameters and Intraocular Pressure With and Without Contact Lenses

“…During the protocol, two aspheric daily disposable CL were fitted: somofilcon A (Clariti 1 Day, CooperVision Inc., Pleasanton, CA) and nesofilcon A (Biotrue ONEday, Bausch & Lomb Inc., NY). 26,27 The parameters of the CL are detailed in Table 1. In all participants, the lens power used was 23.00 D to ensure the same thickness in all cases based on the manufacturer's data provided.…”

Association of Rheumatoid Arthritis with Aqueous Deficient Dry Eye Development

“…Immediately following the FBUT assessment, corneal staining was evaluated and recorded by the Keratograph 5M using the uorescein function while the participants remained seated in the same position [20]. Participants were instructed to focus on a red target at the center of the device, after which they were asked to look in various directions (right, left, up, and down) to assess the paracentral areas; during the "look down" phase, the upper lid was slightly manipulated to examine the upper part of the cornea [23,24]. A second masked examiner assessed the recorded videos of this test using the Oxford Scheme, which grades the severity of dry eye as mild (stage 0 or 1), moderate (stage 2 or 3), or severe (stage 4 or 5) [23,24].…”