2012
DOI: 10.1590/s0102-86502012001000009
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Evaluation of Langerhans cells counts comparing HIV-positive and negative anal squamous cell-carcinoma patients

Abstract: PURPOSE:To investigate the differences in Langerhans cells (LCs) populations between HIV-positive and negative anal squamous cell carcinomas patients. METHODS:Twenty five patients (14 HIV-positive and 11 HIV-negative) were evaluated. Paraffin-block transversal thin sections from biopsies of anal squamous cell carcinomas (ASCC) were stained using the anti-CD1A antibody that identifies activated LCs. LCs counts were performed using histometry at 20 different sites, at baseline in the ASCC cases. These were then … Show more

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Cited by 3 publications
(4 citation statements)
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“…This can be explained by the limited sample size effect. Regarding the specific patient group evaluated in the present study, some authors (19,20) have suggested that HIV infection may be an independent factor, decreasing the density of LCs even in patients with normal CD4+ T cell counts and undetectable viral load. In view of these findings, it is possible that the development of neoplasias and opportunistic infections in HIV-positive patients may be related to HIV infection even with the apparent immunological reestablishment achieved by the success of modern antiretroviral therapies.…”
Section: Discussionmentioning
confidence: 84%
See 1 more Smart Citation
“…This can be explained by the limited sample size effect. Regarding the specific patient group evaluated in the present study, some authors (19,20) have suggested that HIV infection may be an independent factor, decreasing the density of LCs even in patients with normal CD4+ T cell counts and undetectable viral load. In view of these findings, it is possible that the development of neoplasias and opportunistic infections in HIV-positive patients may be related to HIV infection even with the apparent immunological reestablishment achieved by the success of modern antiretroviral therapies.…”
Section: Discussionmentioning
confidence: 84%
“…Furthermore, LCs migration inhibition caused by tumor-derived factors prevents LCs from promoting antitumoral immunity (15)(16)(17). Previous studies have shown the low density of LCs in squamous cell carcinoma (SCC) of the skin (18), uterine cervix (19), and anal mucosa (20). Although the relationship among CD4+ T (T helper cells) cell counts, HIV viral load, and LCs density remains unclear (21), these studies suggest that immunological changes associated with HIV infection are predisposing factors to the development of SCC.…”
Section: Introductionmentioning
confidence: 99%
“…In addition, they are eliminated from the body through the action of the immune system; they may be of subclinical and/or transitory nature. 18,20 Some of them may be latent; however, they may be reactivated and lead to the development of benign clinical lesions such as anogenital warts or intraepithelial lesions. These lesions may regress or persist and develop into anal cancer.…”
Section: Discussionmentioning
confidence: 99%
“…HIV infection has changed the epidemiological profile of anal squamous cell carcinoma (ASCC), and the rate is at least twice as high in HIV-positive as in HIV-negative individuals [3,4]. Previously, ASCC was evident in elderly female patients, whereas nowadays young male patients with this cancer are seen [5].…”
Section: Introductionmentioning
confidence: 99%