Evaluation of in-vitro antimicrobial activity of Artemisia &amp;nbsp;apiacea H. and Scutellaria baicalensis G. extracts

Trinh, Huan; Yoo, Youngchul; Won, KyungHwa; Ngo, Hien T. T.; Yang, Jung Eun; Cho, Jin‐Gyeong; Lee, Sang‐Won; Kim, Ki‐Young; Yi, Tae–Hoo

doi:10.1099/jmm.0.000709

Cited by 22 publications

(9 citation statements)

References 21 publications

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“…The results of the study indicated that A. apiacea and S. baicalensis were effective against Aspergillus niger, C. albicans, Bacillus subtilis and S. aureus with a range of 0.03125 to 4 mg/ml MIC values. Interestingly, 3:5 ratio mixture of A. apiacea and S. baicalensis were found to be more effective than A. apiacea or S. baicalensis used individually [22]. Extraction method can change the chemical composition, so the biological activity of plants.…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial activity of three Scutellaria L. species from Turkey

Arıtuluk¹,

Özkul²,

Renda³

et al. 2019

jrp

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Plant-sourced antimicrobials are known for their therapeutic potency against multi-drug-resistant pathogens. The members of Scutellaria L. have been used to cure several diseases in East Asia, Europe, and North America. The genus Scutellaria belonging to Lamiaceae family is composed of around 360 species worldwide and 18 species in Turkey. In this study, 36 extracts prepared with different solvents from aerial parts and roots of S. salviifolia Benth., S. diffusa Benth. and S. pontica C. Koch were investigated for their antimicrobial activity against four bacteria (Escherichia coli ATCC 25922, Enterococcus faecalis ATCC 29212, Pseudomonas aeruginosa ATCC 27853, Staphylococcus aureus ATCC 29213) and three yeasts (Candida albicans ATCC 90028, C. krusei ATCC 6258, C. parapsilosis ATCC 90018) by using the broth microdilution method. Gentamicin, vancomycin and fluconazole were used as positive control. According to our results, all of the tested extracts showed stronger antimicrobial activity against yeasts than bacteria. The chloroform extract of S. salviifolia root showed the highest antifungal effect against C. krusei with 32 μg/ml MIC value compared with all the tested extracts and the positive control fluconazole (64 μg/ml MIC value).

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Section: Resultsmentioning

confidence: 99%

Antimicrobial activity of three Scutellaria L. species from Turkey

Arıtuluk¹,

Özkul²,

Renda³

et al. 2019

jrp

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“…Previous studies have demonstrated that Scutellaria baicalensis extract and one of its primary bioactive constituents, baicalein, exhibited in vitro activity against various morphologic forms of Borrelia burgdorferi and Borrelia garinii (Goc et al, 2015;Feng J. et al, 2020). In traditional Korean medicine, Scutellaria baicalensis was combined with Artemisia apiacea for the treatment of malaria and other malaria-like diseases (Trinh et al, 2018). Existing clinical trial data on Scutellaria baicalensis indicates it is non-toxic and has systemic effects showing benefits in diabetes, enterovirus encephalitis, and adjunctive cancer care (Smol'ianinov et al, 1997;Lin et al, 2016;Shin et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Botanical Medicines Cryptolepis sanguinolenta, Artemisia annua, Scutellaria baicalensis, Polygonum cuspidatum, and Alchornea cordifolia Demonstrate Inhibitory Activity Against Babesia duncani

Alvarez-Manzo

Leone²,

Schweig³

et al. 2021

Front. Cell. Infect. Microbiol.

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Human babesiosis is a CDC reportable disease in the United States and is recognized as an emerging health risk in multiple parts of the world. The current treatment for human babesiosis is suboptimal due to treatment failures and unwanted side effects. Although Babesia duncani was first described almost 30 years ago, further research is needed to elucidate its pathogenesis and clarify optimal treatment regimens. Here, we screened a panel of herbal medicines and identified Cryptolepis sanguinolenta, Artemisia annua, Scutellaria baicalensis, Alchornea cordifolia, and Polygonum cuspidatum to have good in vitro inhibitory activity against B. duncani in the hamster erythrocyte model. Furthermore, we found their potential bioactive compounds, cryptolepine, artemisinin, artesunate, artemether, and baicalein, to have good activity against B. duncani, with IC50 values of 3.4 μM, 14 μM, 7.4 μM, 7.8 μM, and 12 μM, respectively, which are comparable or lower than that of the currently used drugs quinine (10 μM) and clindamycin (37 μM). B. duncani treated with cryptolepine and quinine at their respective 1×, 2×, 4× and 8× IC50 values, and by artemether at 8× IC50 for three days could not regrow in subculture. Additionally, Cryptolepis sanguinolenta 90% ethanol extract also exhibited no regrowth after 6 days of subculture at doses of 2×, 4×, and 8× IC50 values. Our results indicate that some botanical medicines and their active constituents have potent activity against B. duncani in vitro and may be further explored for more effective treatment of babesiosis.

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“… 28 It is thought that honey acts to modulate the immune response by stimulation and/or inhibition of regulatory cytokines, such as tumor necrosis factor-α, interleukin-1β, and interleukin-6. 29 Other active constituents of B&W ointment, such as aloe vera gel, 30 comfrey root, 31 and wormwood, 32 have been investigated individually and shown to be effective in reducing bacterial and fungal activity.…”

Section: Discussionmentioning

confidence: 99%

Honey-Based Salve and Burdock Leaf Dressings as an Alternative to Surgical Debridement of a Traumatic Wound Eschar

Schell

Copp

Bogie

et al. 2019

Advances in Wound Care

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Objective: Nonviable necrotic eschar is an impedance to wound healing and can ultimately lead to failure of soft tissue coverage in traumatic or high-risk wounds. Topical therapeutic agents can provide a less invasive management alternative to surgical debridement of eschar.Approach: The case of a 40-year-old male with a traumatic right lower extremity amputation complicated by surgical incision ischemic eschar formation is reported. Honey-based salve with burdock leaf dressings was used to noninvasively manage eschar extending over the incision site. Images were obtained for 5 months of follow-up.Results: Five-month follow-up demonstrated complete resolution of eschar and re-epithelialization of skin in the affected region.Innovation: Honey-based salve with burdock leaf dressings shows promise for enhancing healing outcomes in traumatic wounds that develop nonviable eschar.Conclusion: Surgical debridement of an amputation stump with large ischemic eschar was avoided with the use of honey-based salve with burdock leaf dressings.

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Evaluation of in-vitro antimicrobial activity of Artemisia  apiacea H. and Scutellaria baicalensis G. extracts

Abstract: A treatment using a mixture of herbs such as THAN-1 would be useful in the suppression of the growth of pathogenic bacterial and fungal strains.

Cited by 22 publications

References 21 publications

Antimicrobial activity of three Scutellaria L. species from Turkey

Antimicrobial activity of three Scutellaria L. species from Turkey

Botanical Medicines Cryptolepis sanguinolenta, Artemisia annua, Scutellaria baicalensis, Polygonum cuspidatum, and Alchornea cordifolia Demonstrate Inhibitory Activity Against Babesia duncani

Honey-Based Salve and Burdock Leaf Dressings as an Alternative to Surgical Debridement of a Traumatic Wound Eschar

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