Antimicrobial activity of three Scutellaria L. species from Turkey

Abstract

Plant-sourced antimicrobials are known for their therapeutic potency against multi-drug-resistant pathogens. The members of Scutellaria L. have been used to cure several diseases in East Asia, Europe, and North America. The genus Scutellaria belonging to Lamiaceae family is composed of around 360 species worldwide and 18 species in Turkey. In this study, 36 extracts prepared with different solvents from aerial parts and roots of S. salviifolia Benth., S. diffusa Benth. and S. pontica C. Koch were investigated for their antimicrobial activity against four bacteria (Escherichia coli ATCC 25922, Enterococcus faecalis ATCC 29212, Pseudomonas aeruginosa ATCC 27853, Staphylococcus aureus ATCC 29213) and three yeasts (Candida albicans ATCC 90028, C. krusei ATCC 6258, C. parapsilosis ATCC 90018) by using the broth microdilution method. Gentamicin, vancomycin and fluconazole were used as positive control. According to our results, all of the tested extracts showed stronger antimicrobial activity against yeasts than bacteria. The chloroform extract of S. salviifolia root showed the highest antifungal effect against C. krusei with 32 μg/ml MIC value compared with all the tested extracts and the positive control fluconazole (64 μg/ml MIC value).

Comparison of The Antimicrobial Activity of Some Scutellaria orientalis L. Taxa Growing in Turkey

“…with values between 64-32 μg/ml. And totally they found higher antifungal activity than antibacterial, in accordance with our results [11].…”

“…MIC results of methanol extract varied between 12,5-25 mg/ml against E. coli, K. pneumoniae, S. enteritidis P. aeruginosa, S. aureus [27]. Arıtuluk et al (2019) found that aqueous, methanol and n-butanol extracts from roots and methanol and n-butanol extracts from aerial parts of S. salviifolia, S. diffusa and S. pontica and n-hexane extracts from root parts of S. diffusa showed low or no antibacterial activity (1024 μg/ml). Aqueous extracts from the aerial parts showed moderate activity with the values of 1024-512 μg/ml; chloroform, ethylacetate and n-hexane extracts of roots and aerial parts showed low to moderate or no activity with the values of 1024-256 μg/ml, 1024-256 μg/ml, 1024-256 μg/ml, respectively.…”

“…Many Scutellaria species have been used in traditional medicine for centuries. The genus has numerous biological activities such as anti-convulsant, anti-cancer, anti-diarrheal, anti-feedant, anti-hypertensive, anti-inflammatory, anti-microbial, anti-oxidant, anti-thrombotic, hepatoprotective and sedative activities [10][11]. Scutellaria species are known as "kaside, korku otu, sancı otu, şimşek otu" in Turkish.…”

Identification of Phenolic Compounds by LC-MS/MS and Evaluation of Bioactive Properties of Two Edible Halophytes: Limonium effusum and L. sinuatum

“…The dried extracts were dissolved in water and partitioned with n -hexane, dichloromethane and ethyl acetate. Each fraction and the methanol extracts were evaporated under vacuum and stored at 4 °C [ 50 ].…”

Crystal, molecular structure and Hirshheld surface analysis of 5-hydroxy-3,6,7,8-tetramethoxyflavone

“…Plants of the genus Scutellaria L. are widespread in Europe, North America, East Asia and are extensively used in traditional Chinese medicine (Shang et al, 2010). Flavonoids isolated from plants of the genus Scutellaria L. exhibit antitumor (Yu et al, 2007), hepatoprotective (Jang et al, 2003), antioxidant (Sauvage et al, 2010), anti-inflammatory (Dai et al, 2013), anticonvulsant (Park et al, 2007), antimicrobial (Arituluk et al, 2019) and antiviral activity (Leonova et al, 2020). The creation of drugs based on flavonoids is based on the establishment of the 'chemical structure-pharmacological properties' relationship, and the determination of the structure of a new flavonoid may become a key starting point.…”