Comparison of The Antimicrobial Activity of Some Scutellaria orientalis L. Taxa Growing in Turkey

Yılmaz, Gülderen; Şimşek, Duygu; Altanlar, Nurten; Çiçek, Mehmet

doi:10.21448/ijsm.732568

Cited by 7 publications

(7 citation statements)

References 20 publications

(22 reference statements)

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“…The Gram-negative bacteria E. coli was inhibited up to 17.9 ± 0.03 mm and K. pneumonia to an extent of 17.3 ± 0.02 mm zones of inhibition by the EtOAc fraction. Our results agree with the reported data published by Ozkul et al [ 28 ] and Yilmaz et al [ 29 ], who tested different fractions of Scutellaria species against selected bacterial and fungal strains. Mostly, Gram-negative strains exhibited high drug resistance in comparison to the Gram-positive bacterial strains, as they do not have high contents of peptidoglycan in their cell walls [ 30 ].…”

Section: Resultssupporting

confidence: 93%

Biomedical Applications of Scutellaria edelbergii Rech. f.: In Vitro and In Vivo Approach

et al. 2021

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In the current study, in vitro antimicrobial and antioxidant activities and in vivo anti-inflammatory and analgesic activities of Scutellaria edelbergii Rech. f. (crude extract and subfractions, i.e., n-hexane, ethyl acetate (EtOAc), chloroform, n-butanol (n-BuOH) and aqueous) were explored. Initially, extraction and fractionation of the selected medicinal plant were carried out, followed by phytochemical qualitative tests, which were mostly positive for all the extracts. EtOAc fraction possessed a significant amount of phenolic (79.2 ± 0.30 mg GAE/g) and flavonoid (84.0 ± 0.39 mg QE/g) content. The EtOAc fraction of S. edelbergii exhibited appreciable antibacterial activity against Gram-negative (Escherichia coli and Klebsiella pneumoniae) strains and significant zones of inhibition were observed against Gram-positive bacterial strains (Bacillus subtilis and Staphylococcus aureus). However, it was found inactive against Candida Albicans and Fusarium oxysporum fungal strains. The chloroform fraction was the most effective with an IC50 value of 172 and 74 µg/mL against DPPH (1,1-Diphenyl-2-picryl-hydrazyl) and ABTS assays, in comparison with standard ascorbic acid 59 and 63 µg/mL, respectively. Moreover, the EtOAc fraction displayed significant in vivo anti-inflammatory activity (54%) using carrageenan-induced assay and significant (55%) in vivo analgesic activity using acetic acid-induced writing assay. In addition, nine known compounds, ursolic acid (UA), ovaul (OV), oleanolic acid (OA), β-sitosterol (BS), micromeric acid (MA), taraxasterol acetate (TA), 5,3′,4′-trihydroxy-7-methoxy flavone (FL-1), 5,7,4′-trihydroxy-6,3′-dimiethoxyflavone (FL-2) and 7-methoxy catechin (FL-3), were isolated from methanolic extract of S. edelbergii. These constituents have never been obtained from this source. The structures of all the isolated constituents were elucidated by spectroscopic means. In conclusion, the EtOAc fraction and all other fractions of S. edelbergii, in general, displayed a significant role as antibacterial, free radical scavenger, anti-inflammatory and analgesic agents which may be due to the presence of these constituents and other flavonoids.

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Section: Resultssupporting

confidence: 93%

Biomedical Applications of Scutellaria edelbergii Rech. f.: In Vitro and In Vivo Approach

et al. 2021

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“…The recent studies uncovered that significant inhibition was exhibited against the Gram-positive bacterial strains as compared to the Gram-negative bacterial strains consented with the findings of Shah et al [ 2 ] which screened S. edelbergii and also the literature stated by Leach et al [ 81 ] for S. baicalensis. Our recent data was not equated to the findings of Arituluk et al [ 82 ], Yilmaz et al [ 26 ], and Ordan et al [ 83 ] for some Scutellaria species.…”

Section: Resultscontrasting

confidence: 90%

“…Thus, it is the basic need to search for an effective natural remedy that has the potential to cure inflammation and relieve pain with less side effects [ 25 ]. Despite recent advancements in pain medicines, scientists continue to seek out safe, effective, and strong analgesic medications derived from plants since they are known to produce low side effects [ 26 , 27 ]. The genus Scutellaria L. (Lamiaceae), also known as skullcap, consist of around three hundred and fifty plant species and is practiced as a traditional remedy in several local communities.…”

Section: Introductionmentioning

confidence: 99%

Scutellaria petiolata Hemsl. ex Lace & Prain (Lamiaceae).: A New Insight in Biomedical Therapies

et al. 2022

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The recent investigation was designed to explore Scutellaria petiolata Hemsl. ex Lace & Prain (Lamiaceae) whole plant in various extracts (methanol (SPM), dichloromethane (SPDCM), n-Hexane (SPNH), and aqueous (SPAQ) for a phytochemicals assessment, ESI-LC-MS chemical analysis, in vitro antimicrobials, and antioxidants and in vivo anti-inflammatory and analgesic potential. The qualitative detection shows that all the representative groups were present in the analyzed samples. The examined samples display the greatest amount of total flavonoid content (TFC, 78.2 ± 0.22 mg QE/mg) and total phenolic contents (TPC, 66.2 ± 0.33 mg GAE/g) in the SPM extract. The SPM extract proceeded to the ESI-LC-MS to identify the chemical constituents that presented nineteen bioactive ingredients, depicted for the first time from S. petiolata mainly contributed by flavonoids. The analyzed samples produced considerable capability to defy the microbes. The SPM extract was observed effective and offered an appreciable zone of inhibition (ZOI), 17.8 ± 0.04 mm against the bacterial strain Salmonellatyphi and 18.8 ± 0.04 mm against Klebsiella pneumonia. Moreover, the SPM extract also exhibited 19.4 ± 0.01 mm against the bacterial strains Bacillus atrophaeus and 18.8 ± 0.04 mm against Bacillus subtilis in comparison to the standard levofloxacin (Gram-negative) and erythromycin (Gram-positive) bacterial strains that displayed 23.6 ± 0.02 mm and 23.2 ± 0.05 mm ZOI, correspondingly. In addition to that, the SPD fraction was noticed efficiently against the fungal strains used with ZOI 19.07 ± 0.02 mm against Aspergillus parasiticus and 18.87 ± 0.04 mm against the Aspergillus niger as equated to the standard with 21.5 ± 0.02 mm ZOI. In the DPPH (2,2-diphenyl-1-picrylhydrazyl) analysis, the SPM extract had the maximum scavenging capacity with IC50 of 78.75 ± 0.19 µg/mL succeeded by the SPDCM fraction with an IC50 of 140.50 ± 0.20 µg/mL free radicals scavenging potential. Through the ABTS (2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) assay, the similar extract (SPM) presented an IC50 = 85.91 ± 0.24 µg/mL followed by the SPDCM fractions with IC50 = 182.50 ± 0.35 µg/mL, and n-Hexane fractions were reported to be the least active between the tested samples in comparison to ascorbic acid of IC50 = 67.14 ± 0.25 µg/mL for DPPH and IC50 of 69.96 ± 0.18 µg/mL for ABTS assay. In the in vivo activities, the SPM extract was the most effective with 55.14% inhibition as compared to diclofenac sodium with 70.58% inhibition against animals. The same SPM crude extract with 50.88% inhibition had the most analgesic efficacy as compared to aspirin having 62.19% inhibition. Hence, it was assumed from our results that all the tested samples, especially the SPM and SPDCM extracts, have significant capabilities for the investigated activities that could be due to the presence of the bioactive compounds. Further research is needed to isolate the responsible chemical constituents to produce innovative medications.

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“…In terms of antigenotoxicity, all of the essential oils assessed showed this preventive effect. Moreover, the manner of defense varied according to the mutagens, i.e., the kinds of defects generated and therefore the kinds of enzymatic identification and activation resulting in translational synthesis or late apoptosis/ necrosis [90][91][92][93][94][95]. .…”

Section: Essential Oils and Their Specificitiesmentioning

confidence: 99%

A Background Search on the Potential Role of Scutellaria and Its Essential Oils

Zehravi

Karthika

Ferdosh

et al. 2022

BioMed Research International

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Scutellaria (Lamiaceae), which contains over 350 species, usually known as skullcaps, is found throughout Europe, the United States, and East Asia. In traditional Chinese medicine, several species are used to wipe out heat-evil and remove surface ills (TCM). The current study examines the ethnopharmacology, biological activity, and chemical substances associated with Scutellaria species. More than 295 chemicals, including flavonoids and diterpenes, have been identified. Scutellaria and its active principles have been shown in studies to have a wide range of pharmacological activities, including antioxidant, antimicrobial, antifeedant, phytotoxic, acaricidal toxicity, antibacterial, anti-inflammatory, and antianalgesic activities. Currently, effective monomeric compounds or active components from Scutellaria have been evaluated for pharmacological action in vivo and in vitro. More data facilitates applications and exploitation of novel medication development.

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Comparison of The Antimicrobial Activity of Some Scutellaria orientalis L. Taxa Growing in Turkey

Cited by 7 publications

References 20 publications

Biomedical Applications of Scutellaria edelbergii Rech. f.: In Vitro and In Vivo Approach

Biomedical Applications of Scutellaria edelbergii Rech. f.: In Vitro and In Vivo Approach

Scutellaria petiolata Hemsl. ex Lace & Prain (Lamiaceae).: A New Insight in Biomedical Therapies

A Background Search on the Potential Role of Scutellaria and Its Essential Oils

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