Abstract:Carcinogenesis concerns several changes that eventually result in the inactivation of tumor suppressor genes and activation of protooncogenes, leading to loss of cell cycle control. Inactivation of p16 seems to be an early event in this process and occurs in approximately 80% of squamous cell carcinoma cases. The aims of this study were to evaluate the immunohistochemical expression of p16 protein in oral and oropharyngeal squamous cell carcinoma cases, with both the tumoral area itself and its surgical margin… Show more
“…Exclusion criteria included: studies with subsites other than the mouth or oropharynx (13), articles without HPV studies (seven), studies of pediatric populations (five), casuistic studies (four), unobtainable data (four), non-human samples (three), case reports or series of cases studies (three), review articles (two), and studies of non-Brazilian populations (one). Based on the criteria, 42 articles 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 were included in the systematic review ( Table 1 ), and it was noted that the great majority of the studies were conducted in the last decade, with oral samples. Figure 1 Flowchart of article selection.…”
Globally, the Brazilian healthy population has a very low oral human papillomavirus infection rate. Other groups, such as at-risk patients or their partners, immunocompromised patients, people with oral lesions and patients with oral cavity or oropharyngeal squamous cell carcinoma have a high risk of human papillomavirus infection.
“…Exclusion criteria included: studies with subsites other than the mouth or oropharynx (13), articles without HPV studies (seven), studies of pediatric populations (five), casuistic studies (four), unobtainable data (four), non-human samples (three), case reports or series of cases studies (three), review articles (two), and studies of non-Brazilian populations (one). Based on the criteria, 42 articles 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 were included in the systematic review ( Table 1 ), and it was noted that the great majority of the studies were conducted in the last decade, with oral samples. Figure 1 Flowchart of article selection.…”
Globally, the Brazilian healthy population has a very low oral human papillomavirus infection rate. Other groups, such as at-risk patients or their partners, immunocompromised patients, people with oral lesions and patients with oral cavity or oropharyngeal squamous cell carcinoma have a high risk of human papillomavirus infection.
“…Infections caused by HPV are generally of the exophytic growth type and proliferate in papillary projections. They may be pediculated or sessile, presenting as multiple, small, reddened, pinky or whitened nodules that increase over the course of time, and are frequently confluent, normally shown by their "cauliflower" aspect [1,9,[12][13][14][15][16][17].…”
Section: Introductionmentioning
confidence: 99%
“…PCR consists of a technique that has revolutionized virology, due to its extremely high sensitivity, capable of detecting up to one viral genome in 100,000 cells, and is the most sensitive method of detection. Another two widely used methods that have equivalent sensitivity are hybrid capture and PCR with general primers This type of PCR is potentially capable of detecting all the mucosal HPVs [9,12,18,[20][21][22][23][24][25][26].…”
The prevalence of the human papilloma virus (HPV) in the oral cavity and oropharynx has not been well elucidated yet. The aim of this study was to correlate the concomitance of prevalence of HPV in genitalia of men and women with or without HIV/Aids, having manifestations in the oral cavity. Dentist’s (DS) attention is justified by the increase in Condylomata acuminatum in the oral cavity and the possible correlation of manifestations in patients´ genitalia. When associated with seropositivity for HIV/Aids, it becomes an important cofactor increasing the possibility of manifestations of the disease in view of the diminished immunity of these patients. The prevalence and concomitance of the percentage of C. acuminatum lesions in genitalia were correlated with those in the oral cavity by using the following variables: gender, age, skin color, category of exposure, habits, general and oral diseases, presence or absence of xerostomia, T-CD4 lymphocytes, and viral load. The results showed the prevalence of 7 (17.95%) for those who presented concomitant genital/oral lesions. Both the experience and results must become public, aiming to disseminate knowledge about the degree of complexity of the epidemic and need for preventive measures to ameliorate propagation of the disease in the population.
“…p16 is a tumor suppression gene, inactivation of which is considered as the major oncogenic event in the carcinogenesis of OSCC. Over expression of p16 is strongly associated with HPV infection and therefore immunohistochemical expression of p16 is considered as a surrogate marker of oncogenic HPV infection [ 9 - 11 ]. Moreover, p16 over expression is also considered a favorable prognostic marker in OSCC, as patients with p16 over expressing tumors have shown better diseases-free survival compared to tumors, which lack p16 expression [ 12 , 13 ].…”
Background p16 is a tumor suppressor gene, over expression of which is considered as a surrogate marker of oncogenic human papillomavirus (HPV) infection. Moreover, p16 over expression correlates with good prognosis in head and neck squamous cell carcinoma (HNSCC). In the present study, we aimed to evaluate the frequency of p16 overexpression in HNSCC in our setup and its association with clinicopathologic parameters. Methods We performed p16 immunohistochemistry (IHC) on 144 cases of HNSCC. Association of p16 overexpression with various clinicopathologic parameters including T-stage, N-stage, grade, recurrence status, and risk factors was evaluated.
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