Prevalence of oral and oropharyngeal human papillomavirus infection in Brazilian population studies: a systematic review

Matos, Leandro Luongo de; Miranda, Giuliana Angelucci; Cernea, Cláudio Roberto

doi:10.1016/j.bjorl.2015.04.001

Cited by 28 publications

(34 citation statements)

References 64 publications

(101 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…22 In 2014, Lopez et al 21 22 In the current study, an HPV positivity rate of 59.1% was found, which was much higher than the prevalence rates reported in previous regional studies. Epidemiologic features such as age, smoking status, and alcohol consumption differ for patients with HPV-positive and HPV-negative tumors.…”

Section: Discussioncontrasting

confidence: 45%

“…Furthermore, the high prevalence of HPV-related OPSCC has been widely described during the last decade in Europe and the United States. Although we observed an overall decreasing prevalence in alcohol and tobacco intake, the prevalence remains very high among patients with OPSCC in the Brazilian population; according to a study conducted by de Matos et al, 22 the prevalence of smoking and alcohol consumption was 87.8% and 75.2%, respectively. 22 In 2014, Lopez et al 21 22 In the current study, an HPV positivity rate of 59.1% was found, which was much higher than the prevalence rates reported in previous regional studies.…”

Section: Discussionmentioning

confidence: 46%

“…10,11 HPV-related OPSCC commonly presents in younger 12 patients who are nonsmokers; the typical clinicopathological presentation is that of a basaloid pattern (differing from the keratinized SCC presentation in patients with HPV-negative OPSCC) 9,13 accompanied by a higher incidence of regional lymph node metastases. Recent data from Brazil shows that the prevalence of HPV associated with OPSCC ranges from 5.6% to 25.6%, [20][21][22] which is in contrast to the 85% observed in Sweden. Such clinical evidence was the basis for the significant modifications that appeared in the most recent TNM classification and for the clinical trials investigating the de-intensification protocols for HPV-positive OPSCC.…”

Section: Introductionmentioning

confidence: 81%

See 1 more Smart Citation

Impact of human papillomavirus status on survival and recurrence in a geographic region with a low prevalence of HPV‐related cancer: A retrospective cohort study

et al. 2019

View full text Add to dashboard Cite

Background: Human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) is associated with better tumor-response rates and survival outcomes. However, in some geographic regions, the impact of HPV infection on prognosis remains unclear. The aim of this study was to describe the patterns of recurrence and survival among patients treated for OPSCC in a geographic region with a reported low prevalence of HPV-related OPSCC. Methods: We retrospectively evaluated 215 patients diagnosed with American Joint Committee on Cancer (AJCC) stages I to IV OPSCC who were treated with upfront surgery or radiation therapy with or without chemotherapy in a tertiary Cancer Center in Brazil. The collected data included demographic information, HPV status, tobacco and alcohol consumption, and pathologic and treatment variables. The patterns of recurrence were recorded according to HPV status. Disease-specific survival and recurrencefree survival were calculated. Results: One hundred twenty-seven (59.1%) patients were diagnosed with HPVpositive OPSCC. According to the AJCC eighth edition, 34 (15.8%), 71 (33%), 47 (21.9%), and 60 (27.9%) patients had stage I, II, III, and IV disease, respectively. Surgery was performed in 109 (50.7%) cases, and upfront chemoradiation regimens were provided in 104 (48.4%, P = .69) patients. Overall, the 5-year cancer-specific survival was 73.5% and 68.1% for patients positive and negative to HPV, respectively. Tobacco status was considered the only independent prognostic factor for survival. Furthermore, HPV status was not associated with differences in recurrence rates (P = .68). While all distant relapses were found to be lung metastases in the HPV-negative group, we observed unusual sites of distant metastases in the HPV-positive group. Conclusions: HPV status was not associated with higher rates of survival among the investigated population. Moreover, smoking status was considered the only independent prognostic factor for survival. Furthermore, patients with HPVpositive tumors were more likely than patients with HPV-negative OPSCC to have unusual distant metastases.

show abstract

“…Another review on oral HPV was published in 2015 but had language restrictions 19. No systematic review has been conducted to estimate the overall prevalence of HPV infection in Brazil.…”

Section: Ethics and Disseminationmentioning

confidence: 99%

Prevalence of papillomavirus in Brazil: a systematic review protocol

et al. 2016

View full text Add to dashboard Cite

IntroductionHuman papillomavirus (HPV) infection is a cause of premalignant and malignant cancer in the lower genital and digestive tracts. In Brazil, there have been no prevalence studies that included a nationwide sample, and the prevalence of HPV has not been determined in many regions.MethodsWe will search the EMBASE, LILACS, MEDLINE, Web of Science and SciELO databases and previously published review articles to identify original research articles assessing HPV prevalence of the perineal (cervical, penile and anal) and oral areas. No exclusion criteria related to language or publication date will apply. 2 reviewers will independently screen for eligibility and perform data extraction. Discrepancies will be resolved through consensus; the opinion of a third reviewer will be sought as necessary. Relevant measures and data about study and population characteristics will be extracted from the included studies. Where possible, study prevalence will be pooled using a random-effects meta-analysis. The methodological quality of the studies will be assessed using an adapted version of the NIH ‘Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies’. The overall quality of evidence will be assessed using Grading of Recommendations Assessment, Development and Evaluation (GRADE).Ethics and disseminationWe expect to estimate the prevalence of perineal and oral HPV infection in the general population as well as the prevalence of HPV infection in individuals with premalignant and malignant lesions in Brazil and its 5 geographic regions. This systematic review does not require ethical approval.Trial registration numberCRD42016032751.

show abstract

“…There have been many cross‐sectional and a few longitudinal studies reporting the prevalence and incidence of oral HPV infections in the USA . However, little is known about oral HPV prevalence among healthy men in other countries such as Brazil and Mexico, where oral HPV prevalence has mostly been estimated in oral cancer and OPC tumor tissue, and among women . Few studies have examined the association between age and oral HPV prevalence, with most conducted among USA populations only …”

Section: Introductionmentioning

confidence: 99%

Oral human papillomavirus prevalence and type distribution by country (Brazil, Mexico and the United States) and age among HPV infection in men study participants

Bettampadi

Villa

Ponce

et al. 2019

Intl Journal of Cancer

View full text Add to dashboard Cite

Incidence of human papillomavirus (HPV) attributable oropharyngeal cancers (OPCs) has been increasing globally, especially among men in high‐income countries. There is a lack of studies comparing oral HPV prevalence by age and country among healthy men. The purpose of our study was to assess oral HPV prevalence by country and age. Participants of the HPV Infection in Men Study (HIM), a cohort of 3,098 healthy men from São Paulo, Brazil, Cuernavaca, Mexico and Tampa, USA, were studied. Oral HPV prevalence and type distribution were assessed using the SPF10 PCR‐DEIA‐LiPA25 system. The prevalence of any HPV in Brazil, Mexico and the US was 8.7% (95% CI: 7.1%, 10.4%), 10.0% (95% CI: 8.3%, 12.1%) and 7.6% (95% CI: 5.9%, 9.5%), respectively, while the prevalence of high‐risk HPV was 5.3% (95% CI: 4.1%, 6.7%), 7.3% (95% CI: 5.7%, 9.0%) and 5.4% (95% CI: 4.0%, 7.0%), respectively. No significant differences in prevalence of grouped HPV types were observed by country despite significant differences in sexual behaviors. However, the age‐specific prevalence of oral HPV differed by country. Brazilian (6.0% [95% CI: 3.4%, 9.7%]) and Mexican (9.2% [95% CI: 5.6%, 14.0%]) participants had peak high‐risk HPV prevalence among men aged 41–50 years whereas the US participants had peak prevalence at ages 31–40 years (11.0% [95% CI: 6.4%, 17.3%]). In conclusion, oral HPV prevalence was low with no difference in overall prevalence observed by country. Factors associated with the differences in oral HPV age‐patterning by country and sexual orientation require further study.

show abstract

Prevalence of oral and oropharyngeal human papillomavirus infection in Brazilian population studies: a systematic review

Cited by 28 publications

References 64 publications

Impact of human papillomavirus status on survival and recurrence in a geographic region with a low prevalence of HPV‐related cancer: A retrospective cohort study

Prevalence of papillomavirus in Brazil: a systematic review protocol

Oral human papillomavirus prevalence and type distribution by country (Brazil, Mexico and the United States) and age among HPV infection in men study participants

Contact Info

Product

Resources

About