Evaluation of extrahypothalamic control of reproductive physiology

Ellendorff, Franz

doi:10.1007/bfb0027688

Cited by 9 publications

(4 citation statements)

References 108 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since then, other studies have been carried out which corroborate these early find ings [3,10,14,16,23] and so presently it is generally be lieved that the hippocampus in the rat is inhibitory to the LH release mechanisms [8,17,20). Careful review of the li terature, however, reveals some studies which are not in complete agreement with this concept [4.…”

supporting

confidence: 60%

Stimulation of the Hippocampus and Ovulation in the Rat: Specific or Nonspecific Effects

Carrillo¹

1981

Neuroendocrinology

View full text Add to dashboard Cite

Bilateral electrochemical stimulation (ECS) of the ventral hippocampus (VHPC) or dorsal hippocampus (DHPC) under acute conditions at 10.00, 12.00 or 13.00 h on proestrus did not interfere with ovulation. When the same ECS of the VHPC was repeated at 12.00 h of proestrus followed by the taking of blood samples at 14.00, 16.00 and 18.00 h under ether anesthesia from the jugular vein, the LH surge and ovulation were significantly (p < 0.05) inhibited. Acute unilateral ECS of the VHPC or passing the same current through a platinum electrode had no effect on the LH surge. When large electrolytic lesions were bilaterally made in the VHPC with a platinum electrode at 12.00 h of proestrus followed by blood samples, the LH surge and ovulation were also inhibited (p < 0.05). Large lesions in the caudate putamen also resulted in a significant (p < 0.05) suppression of the LH surge and the number of ova. These data suggest that (1) electrochemical stimulation of the hippocampus is not inhibitory to ovulation, and (2) acute procedures on the day of proestrus can inhibit LH secretion.

show abstract

supporting

confidence: 60%

Stimulation of the Hippocampus and Ovulation in the Rat: Specific or Nonspecific Effects

Carrillo¹

1981

Neuroendocrinology

View full text Add to dashboard Cite

show abstract

“…Inhibitory effects of the amygdala on gonadotrophin secretion have also been described (Elwers & Critchlow, 1960; EUendorff et al, 1973 ; Eleftheriou & Zolovick, 1967) and it has been suggested that the basolateral nucleus suppresses, whereas the corticomedial nuclei facilitates, LH release (Kaada, 1972). However, interpretation of conflicting data should take into account the problems of specificity of lesions and parameters of stimulation, as well as different directions of response between intact, cyclic and ovariectomized rats (EUendorff, 1976).…”

Section: Discussionmentioning

confidence: 99%

Modulatory effects of the amygdala on oestrogen-induced LH secretion in ovariectomized rats

Perkins¹,

Whitehead²

1979

Reproduction

View full text Add to dashboard Cite

An increase in LH secretion was induced in ovariectomized oestradiol benzoate-primed rats 5 h after a second injection of oestradiol benzoate. Lesions stereotaxically placed in the cortical and basomedial amygdala of steroid-primed rats abolished this rise. The results provide evidence for a facilitatory action of the amygdala upon LH release and an involvement of this region of the limbic system in oestrogen-feedback mechanisms.

show abstract

“…Analogous to events in the neu rohypophyseal system, one might then anticipate that a change in the frequency of action potential generation in the tuberoinfundibular system would alter release of hypophysiotrophic factors from median eminence nerve termi nals. A relationship between hormone release and neural activity in tuberoinfundibular neurons has been difficult to achieve, although indirect evidence suggests that release in creases in proportion to the frequency of depolarizing sti muli [8,10,37], Adenohypophyseal secretions are also subject to modifi cation by lesions or electrical stimulation in several extrahypothalamic structures [7,11,22,46,48] that do not appear to innervate the median eminence directly. It seems reaso nable to assume that these areas provide afferent connec tions to tuberoinfundibular neurons and mediate their ef fects through alterations in the excitability of tuberoinfun dibular neurons.…”

Section: Afferent Connectionsmentioning

confidence: 99%

A Neurophysiological Approach to the Identification, Connections and Pharmacology of the Hypothalamic Tuberoinfundibular System

Renaud¹

1981

Neuroendocrinology

View full text Add to dashboard Cite

Hypothalamic hypophysiotropic or ‘tuberoinfundibular’ neurons can be identified by antidromic activation following electrical stimulation on the surface of the median eminence. These neurons appear to be localized within the medial hypothalamic and preoptic areas. Both the source and the nature (i.e. excitatory or inhibitory) of connections of these identified neurons can be examined with electrophysiological methods. Afferent pathways appear to originate in the medial preoptic area, amygdala, hippocampus, lateral septum and retina. Axon collaterals of some tuberoinfundibular neurons engage recurrent excitatory and inhibitory pathways and/or project to the anterior hypothalamic area, medial preoptic area, paraventricular nucleus, amygdala, lateral septum and midline thalamus. Neuropharmacological studies indicate that gamma-aminobutyric acid, catecholamines and possibly some hypothalamic peptides may participate in synaptic transmission in afferent or efferent connections in the tuberoinfundibular system.

show abstract

Evaluation of extrahypothalamic control of reproductive physiology

Cited by 9 publications

References 108 publications

Stimulation of the Hippocampus and Ovulation in the Rat: Specific or Nonspecific Effects

Stimulation of the Hippocampus and Ovulation in the Rat: Specific or Nonspecific Effects

Modulatory effects of the amygdala on oestrogen-induced LH secretion in ovariectomized rats

A Neurophysiological Approach to the Identification, Connections and Pharmacology of the Hypothalamic Tuberoinfundibular System

Contact Info

Product

Resources

About