Stimulation of the Hippocampus and Ovulation in the Rat: Specific or Nonspecific Effects

Carrillo, Alberto J.

doi:10.1159/000123235

Cited by 11 publications

(4 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…If epilepsy surgery influences endocrine gonadotrophic dysfunction in female patients, menstrual disorders should normalize following successful surgery. The possible impact of epileptic discharges from the temporal lobes on these endocrine functions has been demonstrated in various studies 1,6,19,20 . The impact of epilepsy which is reported in humans is supplemented by findings in animal models of epilepsy 21,22 .…”

Section: Patmentioning

confidence: 98%

The impact of epilepsy surgery on sex hormones and the menstrual cycle in female patients

Bauer¹,

Stoffel‐Wagner

Flügel³

et al. 2000

Seizure

View full text Add to dashboard Cite

We investigated the impact of temporal lobe epilepsy surgery on sex hormones and menstrual cycles. Sixteen female patients with temporal lobe epilepsy were investigated prior to surgery and 3, 6, and 12 months after surgery. The patients received carbamazepine (CBZ) as monotherapy (10 patients) or in combination with other antiepileptic drugs (six patients). Antiepileptic drugs were maintained after surgery. During the 1-year follow-up after surgery eight patients (50%) remained completely free of seizures. In another four patients (25%) only rare disabling seizures occurred. There were no significant differences between pre-surgical and post-surgical serum concentrations of testosterone, free testosterone, prolactin, dehydroepiandrosterone sulfate, growth hormone, cortisol and sex hormone binding globulin. There was, however, a significant increase in serum androstenedione concentration 6 months post-surgically (P < 0.02). Documentation of menstrual cycles in addition to laboratory parameters revealed individual post-surgical changes of the menstrual cycle in eight patients. Four patients had a change in menstrual periodicity: two patients with complete seizure control had regular cycles instead of oligomenorrhoea and two patients with incomplete seizure control had oligomenorrhoea instead of regular cycles. These data indicate that at least in some patients with temporal lobe epilepsy surgical treatment influences menstrual periodicity.

show abstract

Section: Patmentioning

confidence: 98%

The impact of epilepsy surgery on sex hormones and the menstrual cycle in female patients

Bauer¹,

Stoffel‐Wagner

Flügel³

et al. 2000

Seizure

View full text Add to dashboard Cite

show abstract

“…Recent investigations suggest the action is weak and requires concurrent stimulation for its expression [ 10], Our finding of a small but significant depression of LH release ( fig. 6) appears to be of the magnitude required.…”

Section: Discussionmentioning

confidence: 50%

“…In particular we have previously reported an ex tensive afferent input from the dorsal septal nucleus [4] and from the subcallosal fornix [5] which is derived from the hippo campus and overlying subiculum. There is considerable indirect evidence suggesting that stimulation of the hippocampus and subiculum can inhibit LHRH release [6-9] although there is some dispute about the matter [10][11][12][13].We here report the effects of electrical stimulation of the DBB, the dorsal septal nucleus and the subcallosal fornix on LH release. …”

mentioning

confidence: 89%

Luteinizing Hormone Release in the Anesthetized Cat following Stimulation in the Diagonal Band of Broca, Dorsal Septum and Fornix

Hubbard

Hyland²,

Sirett³

1990

Neuroendocrinology

View full text Add to dashboard Cite

The release of luteinizing hormone (LH) in response to electrical stimulation of septal nuclei (the diagonal band of Broca, DBB, and dorsal septal nucleus) and the subcallosal fornix has been studied in gonadectomized female cats. The cats were anesthetized with Althesin. Electrodes were placed on the medial and lateral aspects of the subcallosal fornix and paired bipolar stimulating electrodes were aimed at the DBB or dorsal septal nucleus. The effect of electrical stimulation of these regions on the secretion of LH was studied by radioimmunoassay of LH in serial blood samples taken before, during and after stimulation. Stimulation in the DBB or in the dorsal septal nucleus resulted in a peak of LH release during stimulation followed by further spontaneous peaks. All peaks showed an exponential decline. The frequency of spontaneous peaks following stimulation could reach the level found in unanesthetized cats. Stimulation of the subcallosal fornix produced a significant depression in the amplitude of LH release. The effects of DBB, dorsal septal and fornix stimulation are all exerted, we suggest, by projections to LHRH containing neurons in the preoptic region.

show abstract

“…Recent studies in this laboratory where ECS was used to study hypothalamic (Carrillo, Hagino & Setalo, 1980) or extrahypothalamic (Carrillo, 1981) control of LH release has led to the present study designed to investigate further the neuroendocrine effects associated with depositing iron and other divalent ions into MPOA on LH release.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical stimulation of the preoptic area and release of luteinizing hormone in the rat: the effects of ferrous and ferric ions

Carrillo¹,

Evans²

1982

Journal of Endocrinology

View full text Add to dashboard Cite

It is well known that 'electrochemical stimulation' (ECS) of the medial preoptic area (MPOA) in the rat results in the release of LH. This neuroendocrine effect is associated with the deposition of iron cations from the electrode tip to the surrounding neural tissue. The present study was designed to investigate further the effect of depositing cations into the MPOA on the release of LH. To this end female rats were anaesthetized on the afternoon of vaginal pro-oestrus with pentobarbitone sodium and brain surgery was performed at 14.00\p=n-\16.00 h. In one group ECS (100 \ g=m\ A anodal d.c. \m=x\60 s) of the MPOA was carried out with a stainless-steel electrode. A platinum electrode was used to pass a current of 200 \g=m\A anodal d.c. \m=x\60 s through another group. Other groups had 1 \ g=m\ l of one of the following solutions injected into the MPOA: FeCl2 (31, 47 and 62 mmol/l); FeCl3 (21, 42 and 83 mmol/l); FeCl2 + FeCl3 (15\m=.\5 and 10\m=.\5 mmol / l respectively); CuCl2 (62 and 120 mmol/l; MgCl2 (62 mmol/l); Ce(SO4)2 (16 mmol/l) and acid 0\m=.\9% NaCl (w/v) solution (pH 2\m=.\7). Blood samples for determination of LH were obtained from the jugular vein at 0, 1 and 2 h. The next morning the uterine tubes were examined for the presence of ova. The smallest concentrations of iron infused corresponded to the number of g equivalents (6\ m=. \ 2 \m=x\10\m=-\8) of iron deposited from the stainless-steel electrode during ECS. Only ECS and injection of the intermediate and highest concentrations of FeCl2 and FeCl3 resulted in a significant (P < 0\ m=. \ 01) rise in plasma LH levels and ovulation when compared to the platinum-treated group. The plasma LH rise after the highest concentration of FeCl2 and FeCl3 was significantly (P < 0\ m=. \ 01) less than that observed after ECS. The other solutions had no significant effect on LH release or ovulation. These data suggest that: (a) iron is the major component responsible for stimulating LH release during ECS although there may be others which potentiate the action of iron, (b) the effect of ECS on LH release is not due to tissue damage (c) other cations do not have a stimulatory effect on LH release.

show abstract

Stimulation of the Hippocampus and Ovulation in the Rat: Specific or Nonspecific Effects

Cited by 11 publications

References 20 publications

The impact of epilepsy surgery on sex hormones and the menstrual cycle in female patients

The impact of epilepsy surgery on sex hormones and the menstrual cycle in female patients

Luteinizing Hormone Release in the Anesthetized Cat following Stimulation in the Diagonal Band of Broca, Dorsal Septum and Fornix

Electrochemical stimulation of the preoptic area and release of luteinizing hormone in the rat: the effects of ferrous and ferric ions

Contact Info

Product

Resources

About