Evaluation of enzyme inhibitory and antioxidant activity of some Lamiaceae plants

Ekin, Hasya Nazlı; Orhan, Didem Deliorman; Orhan, İlkay Erdoğan; Orhan, Nilüfer; Aslan, Mustafa

doi:10.12991/jrp.2019.184

Cited by 6 publications

(8 citation statements)

References 45 publications

(44 reference statements)

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“…On the other hand, antialzheimer, antidiabetic, antioxidant and antiobesity activities of ethanol extracts of T. zygioides var. lycaonius has previously been reported [29]. Also, antioxidant activity of hexane, ethyl acetate, methanol and water extracts of T. longicaulis subsp.…”

Section: Resultsmentioning

confidence: 79%

Antioxidant activities of aqueous extracts from two Thymus species growing in Turkey Primary tabs

Özer

2020

GSC Biol. and Pharm. Sci.

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In this study, antioxidant activities of aqueous extracts from of Thymus longicaulis subsp. chaubardii (Rchb.f.) Jalas and T. longicaulis subsp. longicaulis C. presl were investigated. Infusion and decoction methods were used to prepare aqueous extracts. 1, 1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging, β-carotene linoleic acid and CUPRAC methods were used to determined antioxidant activities. Aqueous extracts of species exhibited good antioxidant activity. Especially, higher antioxidant capacity was found in decoction extracts compared to infusion extracts for all methods.

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Section: Resultsmentioning

confidence: 79%

Antioxidant activities of aqueous extracts from two Thymus species growing in Turkey Primary tabs

Özer

2020

GSC Biol. and Pharm. Sci.

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“…A study by Ekin et al (2019) focused on antialzheimer, antidiabetic, antioxidant and antiobesity activities of ethanol extracts from S. sclarea. Leaf extract of S. sclarea significantly inhibited butyrylcholinesterase (51.76 ± 1.04%).…”

Section: Tablementioning

confidence: 99%

“…Extracts from flowers of S. sclarea (1.34 ± 0.08) and leaves (1.34 ± 0.08) exihibited high ferric-reducing antioxidant power. Extracts of S. sclarea displayed notable inhibitory activity and are considered possible sources of alpha-glucosidase inhibitors (Ekin et al, 2019).…”

Section: Tablementioning

confidence: 99%

Effect of Salvia officinalis and S. sclarea on rats with a high-fat hypercaloric diet

Lieshchova

Bohomaz

Brygadyrenko

2021

Regul. Mech. Biosyst.

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Phytotherapy for the correction of excess body weight is widely used. However, a comprehensive study of herbal preparations on the organism of model animals has been carried out only for a few plant species. Supplementing the diet of rats with closely related sage species (Salvia officinalis L. and S. sclarea L.) against the background of high-fat hypercaloric diet triggered multidirectional changes in their metabolism. The addition of crushed dry shoots of S. officinalis to the diet of animals led to a sharp increase in their body weight (up to 130.8% of the initial one in 30 days of the experiment). The body weight of the rats treated with S. sclarea for 30 days increased only up to 103.8% of their initial weight and was lower than in the control group. Addition of S. officinalis caused an increase in daily weight gain up to 253.1% of the control group, and S. sclarea – its decrease to 27.8% of the daily weight gain in the control group. In the S. officinalis group, the relative weight of the brain, spleen, and thymus decreased, while in the S. sclarea group, the relative weight of the thymus decreased and that of the colon increased. Under the influence of S. officinalis, the concentration of urea, total bilirubin, and triglycerides in the blood plasma of male rats decreased and the concentration of total protein and the activity of alkaline phosphatase increased. While consuming S. sclarea shoots, there was an increase of alkaline phosphatase activity in the rats’ blood, but atherogenic index (23.1% of the level of the control group) sharply dropped due to an increase in the concentration of high-density lipoprotein cholesterol (286.9% of the control) and a decrease in the concentration of low-density lipoprotein cholesterol (67.7% of control). In rats feeding on S. sclarea shoots, we observed a decrease in the concentration of triglycerides in the blood (39.9% of the control), a decrease in the activity of gamma-glutamyl transferase (62.8%), and an increase in the Ca/P ratio (132.5% of the control group). No significant changes were observed in CBC and WBC differential of male rats when eating S. officinalis and S. sclarea shoots. According to the results of the open field test, the physical and orientational activity of male rats under the influence of S. officinalis significantly decreased by the end of the experiment. Emotional status of rats, on the contrary, decreased when they ate dry crushed shoots of S. sclarea in the composition of the food. Thus, excess body weight of rats in the conditions of hypercaloric diet led to more pronounced deviations from the norm while consuming dry crushed shoots of S. officinalis. The addition of S. sclarea dry crushed shoots to the animals’ diet normalized the body weight in comparison with the control group, reduced the negative manifestations of obesity at the biochemical and organismal levels. In this regard, the substances that contains S. sclarea should be carefully studied for anti-atherosclerotic activity, and tea supplemented with S. sclarea shoots can be recommended as a corrective supplement in the diet of overweight people.

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“…The genus Salvia comprises nearly 1000 species, many of which are proved for their bioactivities, including enzyme inhibiting effects. Methanolic, ethanolic and aqueous extracts, mainly obtained from aerial parts of different Salvia species, showed high anti-TYR capacity in numerous studies (Ekin et al, 2019;Halfon et al, 2019;Yener, 2020;Zengin et al, 2018b;c;e) (Table 1) To isolate active components, whole plants and separated plant parts (roots, rhizomes, leaves, flowers, fruits, different fruits parts) have been exploited (Table 1). During the investigated period, considering the total number of samples examined for anti-TYR activity, whole plant/aerial parts (45 %) were most frequently used for plant preparations, followed by leaves (19 %), stems (9 %), roots (8 %), rhizomes (7 %), etc.…”

Section: Potential Of Medicinal Plants In Pd Therapymentioning

confidence: 99%

Enzyme inhibitors as controllers of neurodegenerative diseases: An update of in vitro effects of medicinal plants

Aradski-Alimpić¹,

Pavlović²,

Janković³

et al. 2021

Lekovite sirovine

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Considering the increase of the elderly population in recent years, the growing prevalence of age-related neurodegenerative diseases (NDDs), including Alzheimer's disease (AD) and Parkinson's disease (PD), has become one of the leading healthcare problems. Currently, available therapies for AD and PD are still limited, while medicinal plants used in traditional medicine for millennia can inhibit enzymes involved in the neurodegeneration processes in AD (acetylcholinesterase, AChE, and butyrylcholinesterase, BChE) and PD (tyrosinase, TYR), hence their inhibiting effects are continuously being investigated especially in the past decade. This study was aimed to review data on medicinal plants as potential cholinesterases and TYR inhibitors reported from January 2018 until May 2021. The literature search was performed using several online bibliographical databases (Scopus, Web of Science, Science Direct, Google Scholar, PubMed, and ResearchGate) and two websites. Data analysis showed that the highest number of representatives belongs to Lamiaceae family (up to 20 %), followed by Asteraceae. Almost half of the tested samples were prepared from whole plant/aerial plant parts followed by leaves. The most frequently tested preparations were methanolic extracts (about 25 % of the samples examined). Additionally, synergistic interactions between different herbs and/or isolated compounds were considered as a promising strategy for further research. The presented data showed that medicinal plants preparations represent an unlimited source for research of new and more effective AD and PD treatments. This review will provide a useful starting point for further research on this topic.

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Evaluation of enzyme inhibitory and antioxidant activity of some Lamiaceae plants

Cited by 6 publications

References 45 publications

Antioxidant activities of aqueous extracts from two Thymus species growing in Turkey Primary tabs

Antioxidant activities of aqueous extracts from two Thymus species growing in Turkey Primary tabs

Effect of Salvia officinalis and S. sclarea on rats with a high-fat hypercaloric diet

Enzyme inhibitors as controllers of neurodegenerative diseases: An update of in vitro effects of medicinal plants

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