Evaluation of cardiac laboratory markers in patients with systemic sclerosis

Montagnana, Martina; Lippi, Giuseppe; Volpe, Alessandro; Salvagno, Gian Luca; Biasi, Domenico; Caramaschi, Paola; Guidi, Gian Cesare

doi:10.1016/j.clinbiochem.2006.03.016

Cited by 54 publications

(26 citation statements)

References 52 publications

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“…Ischemia in any organ before infarction can lead to IMA elevation within 6-10 minutes, remaining positive for up to 6 hours (20). Apart from acute coronary syndrome (20), chronically elevated levels of IMA have been detected in many clinical conditions, such as intrauterine pathologies and systemic sclerosis (21,22). Confirming our results, high levels of IMA were recently reported in PCOS cases (15).…”

supporting

confidence: 92%

Ischemia-modified albumin and cardiovascular risk markers in polycystic ovary syndrome with or without insulin resistance

Çağlar

Öztaş

Karadağ

et al. 2011

Fertility and Sterility

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supporting

confidence: 92%

Ischemia-modified albumin and cardiovascular risk markers in polycystic ovary syndrome with or without insulin resistance

Çağlar

Öztaş

Karadağ

et al. 2011

Fertility and Sterility

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“…IMA may not be specific for cardiac ischemia. There are various data on IMA in patients with different states with ischemia of non-cardiac origin such as systemic sclerosis, peripheral vascular disease, skeletal muscle ischemia, glaucoma and diabetes mellitus Montagnana et al, 2006;Piwowar et al, 2008). Also, serum IMA levels are increased in patients with gastric, prostate, neuroblastoma and soft tissue cancer (Mastella et al, 2009;StachowiczStencel et al, 2011;Fidan et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Ischemia Modified Albumin Levels and Oxidative Stress in Patients with Bladder Cancer

Elli̇dağ¹,

Eren²,

Aydın³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: Impaired oxidative/antioxidative status plays an important role in the pathogenesis of many diseases like cancer. The aim of this study was to evaluate the levels of the novel marker ischemia modified albumin (IMA) and albumin adjusted-IMA (Adj-IMA) in patients with bladder cancer (BC) as well as its association with total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI). Materials and Methods: Forty male patients with BC (mean age, 67.4±12 years) and forty age-sex matched healthy persons (mean age 56.0±1.7 years) were included in this study. Serum levels of IMA, TAS, TOS were analyzed and Adj-IMA and OSI was calculated. Results: Serum IMA, TOS and OSI values were significantly higher in patients with BC compared to controls (p<0.0001, p=0.01 and p=0.01, respectively), whereas TAS was significantly lower in BC patients (p=0.04). There was no significant difference for serum albumin-adjusted IMA levels between groups (p=0.4). Conclusions: In this study, it was found that there was an impaired oxidative/antioxidant status in favor of oxidative stress in BC patients. This observation was not confirmed by Adj-IMA calculation. There is no published report about serum concentrations of IMA in patients with BC. Further studies are needed to establish the relationship of IMA and oxidative stress parameters in BC and the significance of IMA to other cancers.

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“…Serum IMA levels have previously been reported to rise significantly in ischemic conditions including lower extremity or myocardial ischemia, pulmonary embolism, deep vein thrombosis, systemic sclerosis and stroke Montagnana et al, 2006;Turedi et al, 2007Turedi et al, , 2009Gunduz et al, 2008a,b;Mentese et al, 2008;Turk et al, 2011]. We established the diagnostic importance of IMA by determining higher IMA levels compared to healthy controls.…”

Section: Discussionmentioning

confidence: 92%

Diagnostic and prognostic value of Ischemia‐modified albumin in patients with Crimean‐Congo hemorrhagic fever

Menteşe

Köksal

Sümer

et al. 2013

Journal of Medical Virology

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The aim of this study was to determine the diagnostic and prognostic significance of ischemia modified albumin (IMA) levels in patients with Crimean-Congo hemorrhagic fever (CCHF). This retrospective study was conducted with patients with CCHF. IMA levels in patients with CCHF were determined using the rapid colorimetric method. IMA levels of CCHF patients were significantly higher compared with the control group (P = 0.0001). At an IMA cut-off point of 0.555 ABSU (absorbance units), sensitivity was 65.1%, specificity 82.5%, positive predictive values (PPV) 82.5%, and negative predictive values (NPV) 65.1%. IMA levels of patients with hemorrhage were significantly higher compared with patients without hemorrhage (P = 0.005). IMA has been validated as both a new and sensitive ischemia and oxidative stress biomarker. In addition to its diagnostic significance, IMA investigated in CCHF patients at time of arrival may be an important marker with its prognostic role in determining in the early stage whether the disease will follow a hemorrhagic course.

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Evaluation of cardiac laboratory markers in patients with systemic sclerosis

Cited by 54 publications

References 52 publications

Ischemia-modified albumin and cardiovascular risk markers in polycystic ovary syndrome with or without insulin resistance

Ischemia-modified albumin and cardiovascular risk markers in polycystic ovary syndrome with or without insulin resistance

Ischemia Modified Albumin Levels and Oxidative Stress in Patients with Bladder Cancer

Diagnostic and prognostic value of Ischemia‐modified albumin in patients with Crimean‐Congo hemorrhagic fever

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