Ischemia Modified Albumin Levels and Oxidative Stress in Patients with Bladder Cancer

Abstract

Background: Impaired oxidative/antioxidative status plays an important role in the pathogenesis of many diseases like cancer. The aim of this study was to evaluate the levels of the novel marker ischemia modified albumin (IMA) and albumin adjusted-IMA (Adj-IMA) in patients with bladder cancer (BC) as well as its association with total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI). Materials and Methods: Forty male patients with BC (mean age, 67.4±12 years) and forty age-sex matched healthy persons (mean age 56.0±1.7 years) were included in this study. Serum levels of IMA, TAS, TOS were analyzed and Adj-IMA and OSI was calculated. Results: Serum IMA, TOS and OSI values were significantly higher in patients with BC compared to controls (p<0.0001, p=0.01 and p=0.01, respectively), whereas TAS was significantly lower in BC patients (p=0.04). There was no significant difference for serum albumin-adjusted IMA levels between groups (p=0.4). Conclusions: In this study, it was found that there was an impaired oxidative/antioxidant status in favor of oxidative stress in BC patients. This observation was not confirmed by Adj-IMA calculation. There is no published report about serum concentrations of IMA in patients with BC. Further studies are needed to establish the relationship of IMA and oxidative stress parameters in BC and the significance of IMA to other cancers.

Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases

“…Epidemiological studies reveal that low levels of antioxidants are associated with an increased risk of cancer. Significant increase in total oxidant status levels and decrease in total antioxidant status were observed in patients with bladder cancer [156]. Significantly lower levels of plasma protein, total thiol groups and proteinbound thiol groups and elevated levels of Protein carbonyl groups were observed in bladder cancer patients than in healthy controls [157].…”

Protective effect of syringic acid on kidney ischemia-reperfusion injury

“…6,24 Studies in recent years have defined IMA as a new marker for diseases related to inflammation. 25 IMA activities are found to be higher in many inflammatory and oxidative stress-associated diseases. 26 Several reports proved that IMA increases within a few minutes after ischemia, remains high during 6-12 h and returns to normal within 24 h. 27 In our study, serum IMA values were significantly higher in the IR group than those in the Sham group.…”

The Phenotype Distribution of Paraoxonase-1 in Patients with Multiple Myeloma, Bladder, and Colorectal Cancer

“…Proteins, lipids and DNA are significant targets for oxidative attack, and modification of these molecules can increase the risk of somatic mutations and neoplastic transformation. In fact, the development of cancers and their progression have already been linked to DNA mutations and damage, genome instability, and cell proliferation caused by oxidative stress (21,22).…”