Ischemia-modified albumin and cardiovascular risk markers in polycystic ovary syndrome with or without insulin resistance

Çağlar, Gamze Sinem; Öztaş, Efser; Karadağ, Demet; Pabuçcu, Recai; Demırtaş, Selda

doi:10.1016/j.fertnstert.2010.06.092

Cited by 41 publications

(26 citation statements)

References 35 publications

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“…A self-assessment questionnaire focusing on hair loss, hair density, greasiness and hair shaft conditions (strength, softness, brightness and volume) was given to all subjects at T 1 , T 3 and T 6 .…”

Section: Assessmentsmentioning

confidence: 99%

“…ii) Female pattern hair loss (FPHL), a diffuse reduction in hair density which affects the crown and the frontal scalp, frequently observed after puberty and affecting up to 50% of women over 50 [4][5][6]. iii) Telogen effluvium (TE), an intense hair shedding and diffuse thinning of hair on the scalp, usually incurring after pregnancy, stressing conditions, surgery or hormonal changes [1].…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of a Nutritional Supplement, Standardized in Fatty Acids and Phytosterols, on Hair Loss and Hair Health in both Women and Men

Zanzottera¹,

Nobile²,

Bizzaro³

et al. 2017

J Cosmo Trichol

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Introduction: Hair health concern is one of the most distressing conditions for a significant number of men and women of all ages. The unique current pharmacologic therapeutic options approved by Food and Drug administration (FDA) are finasteride and topical minoxidil; however, these treatments may have side effects and may work on just one cause of hair loss, without giving an exhaustive and complete results.

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Section: Assessmentsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Efficacy of a Nutritional Supplement, Standardized in Fatty Acids and Phytosterols, on Hair Loss and Hair Health in both Women and Men

Zanzottera¹,

Nobile²,

Bizzaro³

et al. 2017

J Cosmo Trichol

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“…In addition, due to increased production of free radicals and reactive oxygen species (ROS) [4], elevated circulating protein carbonyls, tumor necrosis factor-α (TNF-α), and decreased insulin signaling [5,6], it is associated with increased biomarkers of inflammation and oxidative stress. Increased inflammatory factors and biomarkers of oxidative stress among patients with PCOS may predict the development of cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM) [7][8][9]. Recent studies have reported that the use of insulin-sensitizing drugs including metformin, rosiglitazone, and pioglitazone improves ovulation by improving clinical and biochemical features of patients diagnosed with PCOS [10].…”

Section: Affiliationsmentioning

confidence: 99%

Selenium Supplementation and the Effects on Reproductive Outcomes, Biomarkers of Inflammation, and Oxidative Stress in Women with Polycystic Ovary Syndrome

et al. 2015

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Selenium supplementation could be effective on reproductive outcomes, biomarkers of inflammation, and oxidative stress among women with polycystic ovary syndrome (PCOS). The aim of the study was to determine the effects of selenium supplementation on reproductive outcomes, biomarkers of inflammation, and oxidative stress in PCOS patients. The present randomized double-blind, placebo-controlled trial was conducted on 64 women aged 18?40 years old with PCOS at the clinic affiliated to Ardabil University of Medical Sciences, Ardabil, Iran. The participants were randomly assigned to 2 groups receiving either 200??g selenium daily (n=32) or placebo (n=32) for 8 weeks. Hormonal profiles, biomarkers of inflammation, and oxidative stress were measured and compared both before and after the treatment. After 8 weeks of intervention, pregnancy rate in the selenium group was higher than in the placebo group: 18.8 (6/32) vs. 3.1% (1/32), p=0.04. In addition, alopecia (40.6 vs. 9.4%, p=0.004) and acne (46.9 vs. 12.5 %, p=0.003) decreased following the consumption of selenium supplements compared with placebo. Additionally, patients who received selenium supplements had significantly decreased serum dehydroepiandrosterone (DHEA) levels (p=0.02), hirsutism (modified Ferriman?Gallwey scores) (p<0.001), serum high sensitivity C-reactive protein (hs-CRP) (p=0.02), and plasma malondialdehyde (MDA) levels (p=0.01) compared with placebo. We did not observe any significant effects of taking selenium supplements on other hormonal profiles, nitric oxide (NO), and other biomarkers of oxidative stress. Taken together, selenium supplementation for 8 weeks among PCOS women had beneficial effects on reproductive outcomes, DHEA, hs-CRP, and MDA levels.

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“…Others looked at ischemia-modified albumin (IMA) that reflects chronic hypoxia and oxidative stress, which was found to be elevated in PCOS. However, only hs-CRP correlated with IMA suggesting that its elevation was a marker of increased oxidative stress perhaps due to the chronic inflammation found in PCOS (21). Urinary albumin excretion (UAE) affects endothelial dysfunction and in diabetes correlates with CVD.…”

Section: Cvr Markers In Bloodmentioning

confidence: 99%

MECHANISMS IN ENDOCRINOLOGY: Recent advances in cardiovascular aspects of polycystic ovary syndrome

Sathyapalan

Atkin²

2012

European Journal of Endocrinology

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Polycystic ovary syndrome (PCOS) has been associated with increased cardiovascular risk (CVR) markers, but population studies have not clarified whether there is an increase in cardiovascular morbidity and mortality. Four different PCOS phenotypes resulted from the Rotterdam criteria that may differ in their CVR potential, thus introducing further complexity. This has led to studies using surrogate CVR markers including biomarkers in blood and imaging such as flow-mediated vasodilatation. In PCOS, both peripheral and central insulin resistance (IR) have been shown. Weight loss has been shown to improve IR and visceral fat, while insulin sensitizer therapies with metformin or thiazolidinediones improve IR and endothelial dysfunction. IR is also found in non-alcoholic fatty liver disease that in turn is very common in PCOS; studies have suggested that IR may be improved by treatment with metformin and omega-3 fish oils. PCOS patients have a more dyslipidemic phenotype that is worse in 'classical PCOS' associated with a higher CVR. Studies with atorvastatin and simvastatin have reported a decrease in the lipid parameters and an improvement in CVR indices including IR, but it is unclear whether this is due to their lipid-lowering action or a pleiotropic effect of the statin. In this expert opinion review, the relevant literature published during the last 2 years was considered. It focuses on some recent important data that has emerged while also exposing the gaps that remain in our knowledge that need to be addressed.

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Ischemia-modified albumin and cardiovascular risk markers in polycystic ovary syndrome with or without insulin resistance

Cited by 41 publications

References 35 publications

Efficacy of a Nutritional Supplement, Standardized in Fatty Acids and Phytosterols, on Hair Loss and Hair Health in both Women and Men

Efficacy of a Nutritional Supplement, Standardized in Fatty Acids and Phytosterols, on Hair Loss and Hair Health in both Women and Men

Selenium Supplementation and the Effects on Reproductive Outcomes, Biomarkers of Inflammation, and Oxidative Stress in Women with Polycystic Ovary Syndrome

MECHANISMS IN ENDOCRINOLOGY: Recent advances in cardiovascular aspects of polycystic ovary syndrome

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