Diagnostic and prognostic value of Ischemia‐modified albumin in patients with Crimean‐Congo hemorrhagic fever

Abstract

The aim of this study was to determine the diagnostic and prognostic significance of ischemia modified albumin (IMA) levels in patients with Crimean-Congo hemorrhagic fever (CCHF). This retrospective study was conducted with patients with CCHF. IMA levels in patients with CCHF were determined using the rapid colorimetric method. IMA levels of CCHF patients were significantly higher compared with the control group (P = 0.0001). At an IMA cut-off point of 0.555 ABSU (absorbance units), sensitivity was 65.1%, specificity 82.5%, positive predictive values (PPV) 82.5%, and negative predictive values (NPV) 65.1%. IMA levels of patients with hemorrhage were significantly higher compared with patients without hemorrhage (P = 0.005). IMA has been validated as both a new and sensitive ischemia and oxidative stress biomarker. In addition to its diagnostic significance, IMA investigated in CCHF patients at time of arrival may be an important marker with its prognostic role in determining in the early stage whether the disease will follow a hemorrhagic course.

Sonographic Findings in Patients With Crimean‐Congo Hemorrhagic Fever

“…Crimean-Congo hemorrhagic fever has been endemic in Turkey for more than a decade, and several studies about the clinical and laboratory findings of the disease and the possible pathogenesis have been published. 3,[10][11][12][13] The large number of patients has brought about increased awareness and expertise, even in other fields of medicine such as radiology. Unfortunately, the suggested link between disease severity and sonographic findings remains unconfirmed.…”

Role of ischemia-modified albumin in clinical practice

“…The viral infection occurs due to tick bite or through the blood or body fluids of domestic animals or CCHF patients. Mentese et al [47] investigated the IMA levels in patients with CCHF. They found that IMA levels were significantly higher in patients with CCHF.…”

Kırım Kongo Kanamalı Ateşinin Abdominal Ultrasonografi Bulguları

“…(Resim 2). [8,[13][14][15][16] Hastalığın etyopatogenezi henüz tam olarak anlaşılamamakla beraber insana bulaşan virüsün yoğun bir sistemik inflamatuar cevaba neden olduğu bilinmektedir.…”