Role of ischemia-modified albumin in clinical practice

Erenler, Ali Kemal; Yardan, Türker; Katı, Celal; Altuntaş, Mehmet; Türedi, Süleyman

doi:10.1515/labmed-2015-0038

Cited by 6 publications

(6 citation statements)

References 54 publications

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“…A number of diseases associated with oxidative stress and the necrotic death of myocardial cells manifest themselves in extracellular Mb and ischemically modified albumin [34,37,38,73,74]. The interaction of serum albumin and hypervalent Mb forms can occur during rhabdomyolysis and ischemic myocardial damage [74][75][76]. This process can also be associated with skeletal muscle ischemia.…”

Section: Discussionmentioning

confidence: 99%

Histidine-Bound Dinitrosyl Iron Complexes: Antioxidant and Antiradical Properties

Shumaev,

Kosmachevskaya,

Nasybullina

et al. 2023

IJMS

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Dinitrosyl iron complexes (DNICs) are important physiological derivatives of nitric oxide. These complexes have a wide range of biological activities, with antioxidant and antiradical ones being of particular interest and importance. We studied the interaction between DNICs associated with the dipeptide L-carnosine or serum albumin and prooxidants under conditions mimicking oxidative stress. The ligands of these DNICs were histidine residues of carnosine or His39 and Cys34 in bovine serum albumin. Carnosine-bound DNICs reduced the level of piperazine free radicals in the reaction system containing tert-butyl hydroperoxide (t-BOOH), bivalent iron ions, a nitroxyl anion donor (Angeli’s salt), and HEPES buffer. The ability of carnosine DNICs to intercept organic free radicals produced from t-BOOH decay could lead to this effect. In addition, carnosine DNICs reacted with the superoxide anion radical (O2•−) formed in the xanthine/xanthine oxidase enzymatic system. They also reduced the oxoferryl form of the heme group formed in the reaction of myoglobin with t-BOOH. DNICs associated with serum albumin were found to be rapidly destroyed in a model system containing metmyoglobin and t-BOOH. At the same time, these protein DNICs inhibited the t-BOOH-induced oxidative degradation of coenzymes Q9 and Q10 in rat myocardial homogenate. The possible mechanisms of the antioxidant and antiradical action of the DNICs studied and their role in the metabolism of reactive oxygen and nitrogen species are discussed.

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Section: Discussionmentioning

confidence: 99%

Histidine-Bound Dinitrosyl Iron Complexes: Antioxidant and Antiradical Properties

Shumaev,

Kosmachevskaya,

Nasybullina

et al. 2023

IJMS

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“…Based on the degree of interaction between IMA and metal ions especially cobalt (Co 2+ ), assays quantifying IMA known as the Albumin Cobalt Binding (ACB) test are used [ 35 , 39 – 41 ]. This test measures IMA in human serum and it is reliable for the early detection of myocardial ischemia [ 40 – 42 ]. Importantly, the ACB test is sensitive to changes in IMA concentration (6–10 min after ischemia) that remain high for 6 h, which contributes to its reliable clinical utility [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

“…This test measures IMA in human serum and it is reliable for the early detection of myocardial ischemia [ 40 – 42 ]. Importantly, the ACB test is sensitive to changes in IMA concentration (6–10 min after ischemia) that remain high for 6 h, which contributes to its reliable clinical utility [ 40 ]. Thus, IMA is also important in the accurate and timely diagnosis of different ischemia-related diseases [ 35 , 39 – 41 ].…”

Section: Discussionmentioning

confidence: 99%

The diagnostic potential of oxidative stress biomarkers for preeclampsia: systematic review and meta-analysis

et al. 2022

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Background Preeclampsia is a multifactorial cardiovascular disorder of pregnancy. If left untreated, it can lead to severe maternal and fetal outcomes. Hence, timely diagnosis and management of preeclampsia are extremely important. Biomarkers of oxidative stress are associated with the pathogenesis of preeclampsia and therefore could be indicative of evolving preeclampsia and utilized for timely diagnosis. In this study, we conducted a systematic review and meta-analysis to determine the most reliable oxidative stress biomarkers in preeclampsia, based on their diagnostic sensitivities and specificities as well as their positive and negative predictive values. Methods A systematic search using PubMed, ScienceDirect, ResearchGate, and PLOS databases (1900 to March 2021) identified nine relevant studies including a total of 343 women with preeclampsia and 354 normotensive controls. Results Ischemia-modified albumin (IMA), uric acid (UA), and malondialdehyde (MDA) were associated with 3.38 (95% CI 2.23, 4.53), 3.05 (95% CI 2.39, 3.71), and 2.37 (95% CI 1.03, 3.70) odds ratios for preeclampsia diagnosis, respectively. The IMA showed the most promising diagnostic potential with the positive predictive ratio (PPV) of 0.852 (95% CI 0.728, 0.929) and negative predictive ratio (NPV) of 0.811 (95% CI 0.683, 0.890) for preeclampsia. Minor between-study heterogeneity was reported for these biomarkers (Higgins’ I2 = 0–15.879%). Conclusions This systematic review and meta-analysis identified IMA, UA, and MDA as the most promising oxidative stress biomarkers associated with established preeclampsia. IMA as a biomarker of tissue damage exhibited the best diagnostic test accuracy. Thus, these oxidative stress biomarkers should be further explored in larger cohorts for preeclampsia diagnosis. Graphical Abstract

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“…Serum IMA has been studied in myocardial infarction, acute coronary syndrome, sepsis, pulmonary embolism, deep vein thrombosis, cerebrovascular disease, carbon mono oxide poisoning, end stage renal disease, chronic hepatitis C, diabetes mellitus, hypertension, and much more. 13 Serum IMA has also been considered as novel biomarker of endothelial damage in diabetic patients. 14 The present research group has also studied serum IMA as an early biomarker in epilepsy.…”

Section: Discussionmentioning

confidence: 99%

The study of association of serum ischemia-modified albumin and prediabetes in women: A case–control study

et al. 2022

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Background: Prediabetes, diabetes, and their associated complications adversely affect women’s health worldwide. Women in the reproductive age group are more prone for developing diabetes and its associated complications such as gestational diabetes and infertility. Hence, it is the need of the hour to diagnose women at risk of pre-diabetes. Oxidative stress, ischemia, and hypoxia have been suggested as important factors in developing prediabetes and its sequels. Aims and Objectives: The present study aimed to study the association of serum ischemia-modified albumin (IMA), namely, a marker of oxidative stress, ischemia, and hypoxia with prediabetes in the women of reproductive age group. Materials and Methods: The present study was carried out in 50 females in the reproductive age group of 19–45 years. The study population was further sub-divided into two groups: Group I consisted of 25 prediabetic patients and Group II consisted of 25 healthy controls. Serum samples of the subjects were analyzed for serum IMA, blood sugar profile, and other routine biochemistry tests. Results: The present study showed that mean serum IMA was raised in prediabetic group as compared to healthy controls. The serum IMA also positively correlated with blood sugar profile. Conclusion: Increased serum IMA could be used as a biomarker for predicting prediabetes in females of reproductive age group. This, in turn, would be helpful in preventing the burden of various complications known to occur in the natural course of prediabetes and diabetes.

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Role of ischemia-modified albumin in clinical practice

Cited by 6 publications

References 54 publications

Histidine-Bound Dinitrosyl Iron Complexes: Antioxidant and Antiradical Properties

Histidine-Bound Dinitrosyl Iron Complexes: Antioxidant and Antiradical Properties

The diagnostic potential of oxidative stress biomarkers for preeclampsia: systematic review and meta-analysis

The study of association of serum ischemia-modified albumin and prediabetes in women: A case–control study

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