Evaluation of binding properties of Plantago psyllium seed mucilage

Abstract

Pharmaceutical ingredients are required in the preparation of a drug tablet: fillers to increase the bulk and lubricants to reduce friction during the tableting process. Some pharmaceutical ingredients require a binder for tableting. This provides the cohesiveness necessary for binding ingredient granules under compression. The quantity used must be carefully regulated, since the tablet must disintegrate after administration to liberate the drug (1). Binders act by causing aggregation of powders, thereby forming granules through the granulation process. They modify the cohesive properties of the granules by promoting the formation of strong cohesive bonds between such particles (2).Mucilages and gums are well known for their medicinal use. In recent times, increasing attention has been given to the application of gums of various sources as phar- Mucilage extracted from Plantago psyllium seeds was evaluated for inertness and safety parameters. The suitability of psyllium mucilage for a pharmaceutical binder was assessed in paracetamol tablets. Properties of the granules prepared using different concentrations of psyllium mucilage was compared with PVP and tragacanth. Psyllium mucilage at 5 % (m/m) was found to be comparable with 3 % (m/m) of PVP. Investigated paracetamol tablets indicated that psyllium mucilage can retard the drug release.

Evaluation of Ocimum basilicum L. seed mucilage as rate controlling matrix for sustained release of propranolol HCl

“…The tensile strength (T) of tablets, which is a measure of the stress necessary to cause diametric fracture of the compact, was determined from the mean data obtained from the hardness test carried out on tablets (n = 10) using an Erweka hardness tester (TBH 30MD, Germany) (19).…”

“…The precipitated gum was filtered, treated with acetone to remove the traces of water and dried in an oven 40°C. The characteristics of mucilage were evaluated based on Saeedi et al study (19).…”

Naturapolyceutics: The Science of Utilizing Natural Polymers for Drug Delivery

“…The seeds are washed repeatedly to remove traces of mucilage on them. The collective filtrates are mixed with ethanol to precipitate the mucilage which is subsequently dried [19]. Mucilage from Plantage ovate Forsskaol seed husk is obtained by soaking the seed in deionized water kept at 80 °C with occasional stirring for 2 h [20].…”

Evaluation of Plantago major L. seed mucilage as a rate controlling matrix for sustained release of propranolol hydrochloride

“…After 2 h, the dissolution medium pH was changed from 1.2 to 7.4 using phosphate buffer. The samples were withdrawn at predetermined time intervals (3,4,5,6,7, and 8 h) and analyzed by the mentioned method. The mean of four determinations was used to calculate drug release from each of the formulations.…”

“…Mucilages are generally carbohydrate polymers obtained from woody and non-woody plant parts such as bark, seeds, sap, roots, rhizomes, fruits, and leaves. Mucilages are used for their binding, thickening, stabilizing, humidifying, disintegrating and release controlling properties in medicines (5)(6)(7). Mucilages from natural sources hydrate and swell on contact with water and have been used for the preparation of single unit dosage forms (8).…”