Evaluation of Plantago major L. seed mucilage as a rate controlling matrix for sustained release of propranolol hydrochloride

Abstract

Polysaccharide mucilage derived from the seeds of Plantago major L. (family Plantaginaceae) was investigated for use in matrix formulations containing propranolol hydrochloride. HPMC K4M and tragacanth were used as standards for comparison. The hardness, tensile strength, and friability of tablets increased as the concentration of mucilage increased, indicating good compactibility of mucilage powders. The rate of release of propranolol hydrochloride from P. major mucilage matrices was mainly controlled by the drug/mucilage ratio. Formulations containing P. major mucilage were found to exhibit a release rate comparable to HPMC containing matrices at a lower drug/polymer ratio (drug/HPMC 2:1). These results demonstrated that P. major mucilage is a better release retardant compared to tragacanth at an equivalent content. The results of kinetic analysis showed that in F3 (containing 1:2 drug/mucilage) the highest correlation coefficient was achieved with the zero order model. The swelling and erosion studies revealed that as the proportion of mucilage in tablets was increased, there was a corresponding increase in percent swelling and a decrease in percent erosion of tablets. The DSC and FT-IR studies showed that no formation of complex between the drug and mucilage or changes in crystallinity of the drug had occurred.

Fabrication and characterization of electrospun Plantago major seed mucilage/PVA nanofibers

“…Plantago major (plantain), flowering plant in the plantaginaceae family, is one of the most abundant and widely distributed plant in the world . The plant produces a large amount of seeds . Leaves of P. major are a safe and effective treatment for wound healing .…”

Hypoglycemic Effect due to Insulin Stimulation with Plantago major in Wistar Rats

“…70%) develop insulindependent diabetes mellitus [13]. In this project, we wanted to compare groups of rats with moderate experimental diabetes or noninsulin dependent diabetes mellitus (index of 130 -250mg/dl of glucose) and groups of rats with severe diabetes or insulin-dependent diabetes mellitus (index> 250 mg/dl of glucose) to compare the stimulation effect of Pm in the insulin secretion in different groups [11][12][13][14][15].…”

“…However, the shape of the alloxan molecule is so similar to that of glucose that the glucose transporter, GLUT2, which is the pancreatic beta cell transmembrane transporter accepts this molecule as a glucose analog and transports it into the beta cell pancreas´s cytosol [8]. Selective beta cell necrosis is due to the production of free radicals in the cytosol by the Alloxan [9][10][11]. Therefore, we decide to use Alloxan because it is the most commonly used chemical for diabetes mellitus induction and is a well-known diabetogenic agent widely used to induce Moderate diabetic animals [12].…”

Properties of macerated herbal oil

“…29,30 The polysaccharide extract from the seeds of this plant have been used as a matrix for controlled release of drugs (drug-releasing matrix). 31 …”