Evaluation of Ocimum basilicum L. seed mucilage as rate controlling matrix for sustained release of propranolol HCl

Exploring Properties of Sweet Basil Seed Mucilage in Development of Pharmaceutical Suspensions and Surfactant-Free Stable Emulsions

“…The yield of the mucilage from the basil seeds was approximately 20-25% of dry seed mass. In the literature, yields of 7.86-25 %have been reported [13,15]. The mucilage started to char or decompose at 250 °C.…”

“…Optimization of extraction conditions for mucilage from sweet basil seed and production of mucilage aerogels have been reported in the literature [14]. Basil seed mucilage has been investigated as a substitute of fat source in the preparation of spongy cake and as rate controlling matrix in the development of sustained release tablets [15]. However, no study could be found indicating the use of sweet basil seed mucilage as a suspending agent or emulsion stabilizer in the formulation of pharmaceutical suspensions and surfactant-free emulsions.…”

Investigation of the Biodynamic Commands Use Effect on Mucilage Content and Germination Behavior in Three Ecotypes of Basil (<i>Ocimum</i> Sp.)

“…under varying condition which one of the reasons is decreased of growing cycle and reduced of seed weight [3]. Basil seeds produce a thick layer of mucilage around the pericarp within minutes after hydration that is most prevalent among plant species adapted to surviving in arid sandy soils, though its significance in determining ecological fitness is unclear, but the ecological importance of seed coat mucilage provided valuable information about its roles in critical stages of the plant life cycle [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27]. The mucilage produced by seeds is reported to be composed of cell-wall polysaccharides that are deposited in testa pericarp cells during development [9].…”

“…The important role of mucilages in germination behavior dependent on species, but seed mucilage is one of physical barrier that inhibits germination by regulates water and oxygen diffusion to the seed embryo [14] and enhances water uptake during germination due to its hygroscopic properties, therefore water absorption is much better than that of non-mucilaginous seeds [27]. Similarly, the result showed that the mucilage content affected in different condition of temperature and soaking duration, so that 1 hour after rainfall in temperate and tropical climates, absorbed water by mucilage remain around the seed [21][22][23][24][25]. Also, seed mucilage can also delay germination by impeding diffusion of oxygen, seed dispersal and defend against pathogens, however, seed mucilage can absorb a large amount of water within a short period of time, which allows strong adherence of seeds to soil particles [27].…”

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“…Hence, OBM was selected as a polymer, in this study, to explore it as sustaining polymer. It is inexpensive, abundantly available, biodegradable, biocompatible, forms viscous solution, and also extensively investigated for various properties such as binding, [16] emulsification, [17] disintegrant, [18] drug release retardant property, [19,20] and additionally proven its potentiality in food industry. [21] However, till now, combined effect of it with HPMC K100M has not yet been studied in the development of GRFDDS.…”