Evaluation of berries of Phytolacca dodecandra for growth inhibition of Histoplasma capsulatum var. farciminosum and treatment of cases of epizootic lymphangitis in Ethiopia

Phytochemical Analysis and Assessment of Antibacterial and Antioxidant Activities of <i>Phytolacca dodecandra</i> L. Herit Leaf Extracts (Phytolaccaceae)

“…From the above table, it is reported the presence of various secondary metabolites namely polyphenols, tannins, saponins, alkaloids, leuco-anthocyanins, anthocynins and steroids & triterpenoids. Mekonnen reported the same profile of metabolites for this species precisely the presence of alkaloids, saponins and phenolic compounds [21]. Studies have shown that the presence of secondary metabolites such as alkaloids, anthocyanins, flavonoids, polyphenols, saponins, tannins, steroids and triterpenes in plants confer the antibacterial activity to plants [22][23].…”

“…In the literature, few studies have reported on the phytochemical composition of P. dodecandra leaves but the chemical composition of other parts of the plant has been reported. However, Mekonnen [21] reported the presence of phenolic compounds in P. dodecandra. Terpenoids: resulting from the condensation of isoprene units, terpenoids with antioxidant activity mainly include monoterpenes, sesquiterpenes, diterpenes and tetraterpenes (Carotenoids) [24].…”

Coccidioidomycosis and Histoplasmosis in Equines: An Overview to Support the Accurate Diagnosis

“…farciminosum have been reported in Iraq, Egypt, Sudan, Central African Republic, Nigeria, Italy, Russia, UK and Ireland, Japan, China, and India [49]. Most of the recent reports are from Ethiopia [50][51][52][53], with high prevalence in towns in mid-altitude regions between 1500 and 2300 m above sea level. The Office International des Epizooties (OIE) previously listed epizootic lymphangitis as a list B disease; however, the infection is no longer listed as notifiable, although still prevalent in some countries [54].…”

Analgesic and Anti-Inflammatory Activity of Total Crude Leaf Extract of <i>Phytolacca dodecandra</i> in Wistar Albino Rats

“…The herb is used in the treatment of various skin disorders such as sore scalp, psoriasis, eczema, boils and many other conditions using the leaf extracts; preparation of good luck charm, detergent and soap in some countries like Uganda, Ethiopia and Somalia [9] [11] [12]. The plant has also been reported to have various pharmacological activities including; antifungal activity [13], molluscidal activity, anti-epileptic effects, anti-malarial activity and analgesic activity [9] [10] [11] [12]. The leaf sap is used in the treatment of otitis [11].…”

“…It is also used traditionally in the induction of abortion by the traditional herbalists and local communities [9]. Phytochemical screening of P. dodecandra, show the presence of various chemical compounds including the saponins, alkaloid, phenolics, steroids, terpenoids and many others [13] [14] and these could be responsible for the pharmacological activities of the plant and its toxic properties [10] [11] [15]. However, whereas P. dodecandra is commonly used by the local communities to relieve pain and inflammatory conditions attributed to various pathological conditions and diseases, its pharmacological activity in management and controlling of these conditions has not been fully scientifically evaluated and documented.…”