Evaluation of analgesic and anti-inflammatory activities of Hydrocotyle umbellata L., Araliaceae (acariçoba) in mice

Abstract

The Hydrocotyle umbellata L. is a specimen of the Araliaceae family popularly known as acariçoba. Its indications in folk medicine include treatment of skin ulcers, and rheumatism. The aim of this study was to evaluate the antinociceptive and anti-inflammatory activities of the ethanolic extract from acariçoba's underground parts (EEA). EEA reduced the nociceptive response of the animals as evaluated in the acetic acid-induced writhing test and in both phases of formalin test. EEA also presented a supraspinal analgesic activity by increasing the pain latency in the hot plate test. Moreover, EEA reduced the leukocytes migration and plasma extravasation to pleural cavity in the carrageenan-induced pleurisy, besides reducing the edema induced by carrageenan until the second hour and also the edema induced by dextran. In conclusion our results showed that EEA of H. umbellata L. presents analgesic and anti-inflammatory activities, and that a blockade of activity or reduction in the release of different mediators, such as histamine and serotonin, could be involved in these pharmacologic effects.

Antinociceptive and Antiinflammatory Activities of Anastatica hierochuntica and Possible Mechanism of Action

“…After a short period, the acute phase is followed by a continuous prolonged response (phase II), which is due to the combined effects of afferent input and central sensitization in the dorsal horn. Central sensitization of the dorsal horn neurons occurred during inflammatory pain, in this phase histamine, serotonin, prostaglandins, bradykinin and cytokines such as tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and IL-8 played major role [31,32] . Suppression of both phases of nociception as observed with the AQAH and CHAH in this study lent strong credence to the presence of both centrally and peripherally mediated effects.…”

Desenvolvimento De Horta Sustentável No Ambiente Escolar Como Proposta De Educação Ambiental

“…O uso de plantas medicinais no Brasil é procedente de culturas indígenas, onde Chile (HENWOOD, 2001;SILVA et al, 2010). A medicina popular faz grande uso das espécies do gênero Hydrocotyle no tratamento de ulceras de pele, dermatites, reumatismo, tuberculose e eczema (FLORENTINO et al, 2013). O gênero Hydrocotyle é representado por 16 espécies, sendo a maioria dos representantes aquáticos ou de lugares úmidos (FIANSCHI, 2005).…”

Therapeutics Activities of Amazonian Plant Himatanthus sucuuba (Spruce ex Müll. Arg.) Woodson (Apocynaceae): A Review

“…showed excellent effect analgesia in male swiss mice [57] related with ethanolic extract from Hydrocotyle umbellata (4000 mg/kg (p.o.)) [69] or methanolic extract of Listea glutinosa leaves (500 mg/kg (i.p.)) [70].…”