Evaluation of a new solid non-aqueous self-double-emulsifying drug-delivery system for topical application of quercetin

Wang, Qiang; Hu, Caibiao; Zhang, Hong; Zhang, Yali; Liu, Tian; Qian, Airui; Xia, Qiang

doi:10.1080/02652048.2016.1264494

Cited by 16 publications

(2 citation statements)

References 42 publications

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“…Another formulation was prepared to improve EPGCG photostability which possess sustained release behaviour. Epigallocatechin 3-gallate (EGCG) and α-lipoic acid was used for preparing SDEDDS formulation [99]. Another new formulation was investigated named as o/o/w double emulsion which is automatically formed after dilution in aqueous phase.…”

Section: Se Suppository Formulations (Non-oral)mentioning

confidence: 99%

Self Emulsifying Drug Delivery System: A Recent Approach

Bindhani

Mohapatra

Kar³

2019

Asian J. Chem.

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In recent years, nearly 40 % newer drugs compounds are hydrophobic in nature, which is a major challenge now-a-days for oral drug delivering due to low aqueous solubility. Lipid based drug delivery system is one of the favourable approach for poorly soluble compounds which can improve the drug absorption and oral bioavailability. Due to ion-pairing with appropriate surfactant and co-surfactant the macromolecular drug molecular oil droplet being found in the gut flow oral absorption which sufficiently stable towards lipase. Due to the formation of emulsified drug in micron level, it can efficiently endow the oral bioavailability. Several comprehensive papers have been published in the literature illustration diverse type of lipid based formulation with recent advancements. This article is based on an exhaustive and updated review on newer technology which out line an explicit discussion on its formulations and industrial scale up.

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Section: Se Suppository Formulations (Non-oral)mentioning

confidence: 99%

Self Emulsifying Drug Delivery System: A Recent Approach

Bindhani

Mohapatra

Kar³

2019

Asian J. Chem.

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“…However, the characteristic peaks disappeared in curcumin microparticles and the spectrum was similar to that of blank microparticles. Therefore, the results indicate that curcumin was incorporated in Aerosil 380 and remained in dissolved state in the microparticles ( 33 , 34 ).…”

Section: Resultsmentioning

confidence: 92%

Silica-Lipid Hybrid Microparticles as Efficient Vehicles for Enhanced Stability and Bioaccessibility of Curcumin

Wang

et al. 2019

Food technol. biotechnol. (Online)

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SUMMARYCurcumin is an active ingredient with multiple functions, but its application is often restricted due to its poor water solubility, weak stability, and consequently low bioaccessibility. Based on this, the aim of this work is to develop a new vehicle to overcome these restrictions. Here we developed a curcumin-loaded nanoemulsion and then curcumin-loaded silica-lipid hybrid microparticles through emulsification and vacuum drying, respectively. The loading of curcumin in the nanoemulsion and microparticles was (0.30±0.02) and (0.67±0.02) %, respectively. FTIR and XRD analyses of microparticles revealed that curcumin was encapsulated in porous, amorphous silica. In vitro antioxidant activities showed that the encapsulation would not affect the antioxidant activity of curcumin. In vitro simulated digestion indicated that nanoemulsion and microparticles had higher curcumin bioaccessibility than the control group. The storage stability of microparticles remained the same during 6 weeks in the dark at 4, 25 and 40 °C. Moreover, the microparticles had a better chemical stability than nanoemulsion under the light. The cell viability was over 80% when the concentration of nanocarriers was less than 45 μg/mL. Hence, the microparticles could be a promising means to load curcumin and improve its solubility, light stability and bioaccessibility.

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