Silica-Lipid Hybrid Microparticles as Efficient Vehicles for Enhanced Stability and Bioaccessibility of Curcumin

Ma, Yudi; Wang, Qiang; Wang, Dantong; Huang, Juan; Sun, Rui; Mao, Xinyu; Tian, Yanhua; Xia, Qiang

doi:10.17113/ftb.57.03.19.6035

Cited by 7 publications

(5 citation statements)

References 44 publications

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“…In vitro simulated digestion tests have shown that curcumin-loaded nanoemulsions and SLH microparticles exhibit enhanced bioaccessibility compared to the control group. Moreover, SLH microparticles have demonstrated consistent storage stability across different temperatures over a period of six weeks [123]. Furthermore, innovative super-saturated SLH (super-SLH) formulations can increase drug loading capacity in cases of compounds having low potency [124].…”

Section: Discussionmentioning

confidence: 99%

Prakshape condiment in Chavanprash: Harnessing Synergy of the Ages

2023

Curr Res Cmpl Alt Med

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Towards the conclusion of the tedious process of preparing chavanprash, a powdered herb combination known as prakshape is introduced. Many of these herbs have already been utilized in the initial stage of creating the decoction, which is the basis of chavanprash. The perplexing aspect is the necessity to incorporate the same herbs once more as prakshape during the final step, highlighting the intriguing nature of this addition and its associated benefits. The inclusion of prakshape proves to be ingenious for multiple reasons. Firstly, the incorporation of powdered herbs in prakshape ensures that the entire herb, along with all its phytochemical components, becomes part of the formulation. In contrast, the decoction process only extracts water -soluble components into the solution. This inclusion allows for a broader range of active compounds to be present in the final product. Secondly, the addition of prakshape serves to reintroduce volatile and heat-labile compounds that may have been lost during the extended heating process. Additionally, the inclusion of bamboo (Bambusa arundinacea) manna particles in prakshape contributes to an enhanced drug-delivery system. From a pharmacological standpoint, the incorporation of prakshape ingredients reinforces the therapeutic effects of the formulation and promotes synergy among the herbs. The principles underlying the use of prakshape can further be utilized for the development of new awaleha and ksheerpak formulations, potentially yielding more potent effects.

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Section: Discussionmentioning

confidence: 99%

Prakshape condiment in Chavanprash: Harnessing Synergy of the Ages

2023

Curr Res Cmpl Alt Med

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“…The in vitro release data of the drug were fitted with the zero-order release equation, the first-order release equation and the Higuchi equation (Ma et al. 2019 ).…”

Section: Methodsmentioning

confidence: 99%

“…The major reason contributing to the rapid metabolism is the poor stability of all Cur metabolites (Ma et al. 2019 ; Slika and Patra 2020 ). Therefore, Cur usually requires frequent dosing.…”

Section: Introductionmentioning

confidence: 99%

Solid lipid nanoparticle as an effective drug delivery system of a novel curcumin derivative: formulation, release in vitro and pharmacokinetics in vivo

Zhao

Zeng

et al. 2022

Pharmaceutical Biology

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Context Curcumin (Cur) has a short duration of action which limits its therapeutic efficacy. Carbonic acid 17-(1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester 4-[7-(4-hydroxy-3-methoxy-phenyl)-3,5-dioxo-hepta-1,6-dienyl]-2-methoxy-phenyl ester (CUD), as a small molecule derivative of Cur with superior stability, has been developed in our laboratory. Objective CUD-loaded solid lipid nanoparticles (CUD-SLN) were prepared to prolong the duration of the drug action of Cur. Materials and methods CUD-SLN were prepared with Poloxamer 188 (F68) and hydrogenated soybean phospholipids (HSPC) as carriers, and the prescription was optimized. The in vitro release of CUD and CUD-SLN was investigated. CUD-SLN (5 mg/kg) was injected into Sprague Dawley (SD) rats to investigate its pharmacokinetic behaviour. Results CUD-SLN features high entrapment efficiency (96.8 ± 0.4%), uniform particle size (113.0 ± 0.8 nm), polydispersity index (PDI) (0.177 ± 0.007) and an appropriate drug loading capacity (6.2 ± 0.1%). Optimized CUD-SLN exhibited sustained release of CUD for about 48 h. Moreover, the results of the pharmacokinetic studies showed that, compared to Cur, CUD-SLN had a considerably prolonged half-life of 14.7 h, slowed its metabolism in vivo by 35.6-fold, and had an improved area under the curve (AUC 0– t ) of 37.0-fold. Conclusions CUD-SLN is a promising preparation for the development of a small molecule derivative of Cur.

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“…The CCK‐8 method was adopted to measure the cytotoxicity of effervescent tablets containing astaxanthin‐loaded microcapsules to L929 murine fibroblast cells. [ 35 ] L929 cells were provided by the Type Culture Collection of the Chinese Academy of Sciences (Shanghai, China). Cells were incubated in a DMEM culture medium with 10% FBS and 1% penicillin‐streptomycin in a 5% CO 2 cell incubator at 37 °C.…”

Section: Methodsmentioning

confidence: 99%

Preparation and characterization of astaxanthin‐loaded microcapsules and its application in effervescent tablets

et al. 2022

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BACKGROUND Astaxanthin is a type of keto‐carotene with potential health benefits. However, astaxanthin has poor solubility and stability, resulting in its low oral bio‐availability. Microcapsules can be used to improve the water solubility, stability and oral bio‐availability of lipophilic bioactive compounds. Effervescent tablets can further improve the stability, smell and taste of microcapsules, and are more easily accepted by consumers. RESULTS Astaxanthin‐loaded microcapsules were prepared by layer‐by‐layer assembly and freeze‐drying technologies. Sodium caseinate and κ‐carrageenan were applied as wall materials. The prepared microcapsules had good flow properties and encapsulation efficiencies (> 85%). Fourier transform infrared spectroscopy demonstrated that the mechanisms of layer‐by‐layer self‐assembly between sodium caseinate and κ‐carrageenan might be electrostatic adsorption and hydrogen bonding. The preparation process and excipients did not affect the antioxidant effect of astaxanthin. The in vitro simulated digestion study showed that microcapsules were mainly dissolved and digested in the simulated intestinal solution. Compared with its raw material, microencapsulation could improve the bio‐accessibility of astaxanthin greatly. Then, astaxanthin‐loaded microcapsules were incorporated into effervescent tablets by wet granulation and tablet‐pressing methods. The dissolution of astaxanthin from effervescent tablets was over 90% in 2 h, which indicated a good dissolution effect. A cytotoxicity study revealed that astaxanthin loaded effervescent tablets had a good biocompatibility. Encapsulating astaxanthin‐loaded microcapsules in effervescent tablets can improve its chemical stability. CONCLUSION Effervescent tablets containing microcapsules could be used to improve the solubility, stability and bio‐accessibility of lipophilic bioactive compounds. © 2022 Society of Chemical Industry.

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Silica-Lipid Hybrid Microparticles as Efficient Vehicles for Enhanced Stability and Bioaccessibility of Curcumin

Cited by 7 publications

References 44 publications

Prakshape condiment in Chavanprash: Harnessing Synergy of the Ages

Prakshape condiment in Chavanprash: Harnessing Synergy of the Ages

Solid lipid nanoparticle as an effective drug delivery system of a novel curcumin derivative: formulation, release in vitro and pharmacokinetics in vivo

Preparation and characterization of astaxanthin‐loaded microcapsules and its application in effervescent tablets

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