Evaluating the antioxidant and anticancer property of Ficus carica fruits

Abstract

The present study was designed to investigate the antioxidant and anticancer properties of Ficus carica (FC). The dried coarse powder of F. carica fruits was exhaustively extracted with ethanol and the resulting crude ethanolic extract (FCE) was assayed for antioxidant and anticancer activities, since both are inter-related. The antioxidant activity of FCE was determined by reductive potential in reducing ferric ions and anticancer activity was determined using breast cancer cell lines (MCF7). The extract showed strong antioxidant and anti-cancer activities, which suggest the use of the plant for therapeutic purposes, supporting the traditional claims.

Nutritional and pharmacological importance of Ficus carica - A review

“…At a concentration of 1000 µg/ml, 85.5 and 89 % inhibition were recorded after 24 and 48 hours, at a concentration of 1000 µg/ml, 85.5 and 89 % inhibition were recorded after 24 and 48 hours. While, at concentration of 500 µg/ml, the recorded inhibition were 76, 80.5 and 82.5 % after 24, 48 and 72 hours [96]. The effect of crude water extracts of Ficus carica upper parts was investigated on cell lines derived from different human tissue origins (Hep3b: Hepatocellular carcinoma; Hela: cervical epithelial cancer; and PC-3: prostate cancer).…”

“…In FRAP assay, FRAP activity was found to be 60.48 in fig extract [64].The antioxidant activities of the Ficus carica was studied using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging method. The extract of Ficus carica showed potent antioxidant activity comparable to standard Ginkgo biloba [96][97].An ethanol extract of fig branches and its ethyl acetate, hexane, butanol, and water fractions were examined for their abilities to scavenge free radicals. The results showed that the ethyl acetate fraction contained the largest amount of phenolic compounds and showed the highest free radical scavenging activity [56].…”

Ficus plants: State of the art from a phytochemical, pharmacological, and toxicological perspective

“…Emetine was the standard drug control (Mbosso Teinkela et al, 2018). In 2015, Jasmine et al (2015) investigated the cytotoxic effect of F . carica on MCF‐7 cells, and several concentrations were tested.…”

Anticancer effects of Arabian medicinal plants (part 1) - A review

“…Ten mg/ml was the optimum concentration in the inhibition of cell line growth. esophageal cancer line Ficus carica 377 The ethanolic extract showed strong anti-cancer activities against breast cancer cell lines (MCF7). At a concentration of 1000 µg/ml, 85.5 and 89 % inhibition were recorded after 24 and 48 hours, at a concentration of 1000 µg/ml, 85.5 and 89 % inhibition were recorded after 24 and 48 hours.…”