Ethyl acetate fraction of Cissus quadrangularis stem ameliorates hyperglycaemia-mediated oxidative stress and suppresses inflammatory response in nicotinamide/streptozotocin induced type 2 diabetic rats

Lekshmi, R.; Rajesh, R; Mini, S.

doi:10.1016/j.phymed.2015.06.014

Cited by 29 publications

(28 citation statements)

References 22 publications

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“…In the present study, a significant rise in the ALP, ALT, AST and GGT serum levels was observed in STZ-induced diabetic rats, whereas the diabetic group treated with EAF showed a significant improvement in these parameters. Several studies have shown that natural products from plants exert beneficial effects by reducing the high levels of ALP, ALT and AST in diabetic individuals, which leads an improvement in hepatic dysfunction [22,[26][27][28].…”

Section: Discussionmentioning

confidence: 99%

Anti-Diabetic Effects of the Ethyl-Acetate Fraction of Trichilia catigua in Streptozo-tocin-Induced Type 1 Diabetic Rats

Gomes

Paulo

Panizzon

et al. 2017

Cell Physiol Biochem

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Background/Aims: Trichilia catigua A. Juss., known as "catuaba" in Brazil, has been popularly used as a tonic for fatigue, impotence and memory deficits. Previously, our group demonstrated that the ethyl-acetate fraction (EAF) of T. catigua has antioxidant and anti-inflammatory effects. The present study evaluated the anti-diabetic activity of EAF in type 1 diabetic rats. Methods: Male Wistar rats were divided into four groups (N: non-diabetic group, D: type 1 diabetic group, NC: non-diabetic + EAF group and DC: type 1 diabetic + EAF group). The latter two groups were treated with 200 mg/kg EAF. Type 1 diabetes was induced by intravenous streptozotocin (STZ) injection (35 mg/kg). Starting two days after STZ injection, EAF was administered daily by gavage for 8 weeks. Results: EAF attenuated body mass loss and reduced food and water intake. EAF improved hyperglycaemia and other biochemical parameters, such as alkaline phosphatase (ALP), alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Furthermore, the number of pancreatic β-cells and the size of the islets had increased by β-cell proliferation in the DC group. EAF promoted reduction in kidney tissue damage in STZinduced diabetic rats by reduction of renal fibrosis. Conclusion: The present study showed that EAF improves glucose homeostasis and endocrine pancreas morphology and inhibits the development of diabetic nephropathy in STZ-induced diabetic rats.

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Section: Discussionmentioning

confidence: 99%

Anti-Diabetic Effects of the Ethyl-Acetate Fraction of Trichilia catigua in Streptozo-tocin-Induced Type 1 Diabetic Rats

Gomes

Paulo

Panizzon

et al. 2017

Cell Physiol Biochem

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“…Many studies have pointed out that oxidative stress would induce aggravated bronchospasms and a serious inflammatory response, deteriorating lung damage in asthma patients ( Araujo et al, 2012 ; Nesi et al, 2017a ). Natural antioxidants resveratrol and quercetin have been shown to improve the pathological manifestations of asthma by blocking oxidative stress in asthmatic mice ( Wood et al, 2010 ; Lekshmi et al, 2015 ). Casticin has anti-oxidative effects, blocking the inflammatory response in LPS-stimulated macrophages by promoting the expression of antioxidant protein HO-1 ( Liou et al, 2014 ).…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Casticin From Vitex trifolia Alleviate Eosinophilic Airway Inflammation and Oxidative Stress in a Murine Asthma Model

et al. 2018

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Casticin has been isolated from Vitex trifolia and found to have anti-inflammatory and anti-tumor properties. We also previously discovered that casticin can reduce pro-inflammatory cytokines and ICAM-1 expression in inflammatory pulmonary epithelial cells. In the present study, we evaluated whether casticin reduced airway hyper-responsiveness (AHR), airway inflammation, and oxidative stress in the lungs of a murine asthma model and alleviated inflammatory and oxidative responses in tracheal epithelial cells. Female BALB/c mice were randomly divided into five groups: normal controls, ovalbumin (OVA)-induced asthma, and OVA-induced asthma treated with intraperitoneal injection of casticin (5 or 10 mg/kg) or prednisolone (5 mg/kg). Casticin reduced AHR, goblet cell hyperplasia, and oxidative responses in the lungs of mice with asthma. Mechanistic studies revealed that casticin attenuated the levels of Th2 cytokine in bronchoalveolar lavage fluids and regulated the expression of Th2 cytokine and chemokine genes in the lung. Casticin also significantly regulated oxidative stress and reduced inflammation in the lungs of mice with asthma. Consequently, inflammatory tracheal epithelial BEAS-2B cells treated with casticin had significantly suppressed levels of pro-inflammatory cytokines and eotaxin, and reduced THP-1 monocyte cell adherence to BEAS-2B cells via suppressed ICAM-1 expression. Thus, casticin is a powerful immunomodulator, ameliorating pathological changes by suppressing Th2 cytokine expression in mice with asthma.

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“…Hyperglycaemia continuously will lead to an increase in free radicals and therefore reduces the antioxidant defense system [7]. Superoxide dismutase (SOD) is one of the enzymatic antioxidant system and is the main (primary) defense against oxidative stress conditions [12].…”

Section: Discussionmentioning

confidence: 99%

“…When the insulin signal is disrupted, the disruption of glucose transport into the cells happens because of impaired GLUT-4 translocation to the plasma membrane [4]. This condition will cause a decrease in glucose utilization in peripheral tissues leading to increased blood glucose levels (hyperglycemia) [5] and if occurring continuously will lead to increased free radicals, which reduce the antioxidant defense system [6,7]. This condition is called oxidative stress and leads to the modification of lipids, DNA, and proteins in different tissues [8][9][10].…”

Section: Background and Aimsmentioning

confidence: 99%

Antioxidant Effect of Purple Eggplant Flour (Solanum melongena L.) Against Oxidative Stress in Hyperglycaemic Rats

Fajriana

Farmawati²,

Lestari³

2017

Romanian Journal of Diabetes Nutrition and Metabolic Diseases

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Ethyl acetate fraction of Cissus quadrangularis stem ameliorates hyperglycaemia-mediated oxidative stress and suppresses inflammatory response in nicotinamide/streptozotocin induced type 2 diabetic rats

Cited by 29 publications

References 22 publications

Anti-Diabetic Effects of the Ethyl-Acetate Fraction of Trichilia catigua in Streptozo-tocin-Induced Type 1 Diabetic Rats

Anti-Diabetic Effects of the Ethyl-Acetate Fraction of Trichilia catigua in Streptozo-tocin-Induced Type 1 Diabetic Rats

Protective Effects of Casticin From Vitex trifolia Alleviate Eosinophilic Airway Inflammation and Oxidative Stress in a Murine Asthma Model

Antioxidant Effect of Purple Eggplant Flour (Solanum melongena L.) Against Oxidative Stress in Hyperglycaemic Rats

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