Ethnopharmacological approaches to Talinum paniculatum (Jacq.) Gaertn. - Exploring cardiorenal effects from the Brazilian Cerrado

Tolouei, Sara Emília Lima; Palozi, Rhanany Alan Calloi; Tirloni, Cleide Adriane Signor; Marques, Aline Aparecida Macedo; Schaedler, Maysa Isernhagen; Guarnier, Lucas Pires; Silva, Aniely Oliveira; Almeida, Valter Paes de; Budel, Jane Manfron; Souza, Roosevelt Isaías Carvalho; Santos, Ariany Carvalho dos; Silva, Denise Brentan; Lourenço, Emerson Luiz Botelho; Dalsenter, Paulo Roberto; Gasparotto, Arquimedes

doi:10.1016/j.jep.2019.111873

Cited by 23 publications

(22 citation statements)

References 33 publications

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“…The presence of these elements indicate that the crystals are formed by calcium oxalate. The occurrence of crystals on both surfaces of the leaves has been described for some species (Homem et al, ; Migacz et al, ; Santos et al, ; Tolouei et al, , ).…”

Section: Resultsmentioning

confidence: 93%

Anatomy, micromorphology, and histochemistry of leaves and stems of Cantinoa althaeifolia (Lamiaceae)

Almeida

Raman

Raeski

et al. 2020

Microscopy Res & Technique

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This article enumerates the detailed anatomy of Cantinoa althaeifolia (Lamiaceae) illustrated with light and scanning electron microscopy images. The anatomical markers include the presence of branched nonglandular trichomes and capitate, peltate, and clavate types of glandular trichomes; prismatic crystals on the leaf and stem surfaces; and oil droplets in the leaf mesophyll. Histochemical tests and EDS analyses were performed in order to detect the composition of certain cells and their contents. The key findings of the present study can contribute to the taxonomy, species identification, and quality control of Cantinoa althaeifolia. K E Y W O R D S crystals, leaf anatomy, micromorphology, stem anatomy, trichomes

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Section: Resultsmentioning

confidence: 93%

Anatomy, micromorphology, and histochemistry of leaves and stems of Cantinoa althaeifolia (Lamiaceae)

Almeida

Raman

Raeski

et al. 2020

Microscopy Res & Technique

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“…This study also demonstrated the hypotensive effect of the extract of A. pyrifolia after prolonged use and found no signs of toxicity during and after treatment with the leaf extract. Finally, the diuretic and hypotensive activity of T. paniculatum, known in Brazil as "caruru", was demonstrated by Tolouei et al [40] in male NTR. The results of that study showed that the ethanol fraction of the oil obtained from the leaves of T. paniculatum after 7 days of treatment in different doses (30, 100, and 300 mg/kg) had diuretic and saluretic effects but did not alter blood pressure or heart rate.…”

Section: Brazilian Medicinal Plants With Diuretic Potentialmentioning

confidence: 91%

“…Gaertn. [40]. The diuretic activity of the leaves of A. pyrifolia, known in Brazil as "cipó-do-mato", was investigated by Tolouei et al [39] in male and female NTR.…”

Section: Brazilian Medicinal Plants With Diuretic Potentialmentioning

confidence: 99%

Promising Medicinal Plants with Diuretic Potential Used in Brazil: State of the Art, Challenges, and Prospects

et al. 2020

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Medicinal plants are used in traditional medicine to treat a wide range of ailments. The knowledge of them is handed down from generation to generation and is described in several pharmacopoeia and in the general literature. The immense biodiversity of the Brazilian flora, covering about 25% of all plant species worldwide, makes Brazil a huge potential source of medicinal plants. Indeed, many of these plant species are already used in the Brazilian ethnopharmacology for their probable effect to induce diuresis, to reduce fluid retention, and to treat cardiovascular and renal disorders. This review article describes and discusses the main native Brazilian medicinal plants (including some of their isolated compounds) used as diuretics. It also gives a comprehensive analysis of the most relevant scientific studies presented to date, as well as addressing a special topic with future prospects for plant species that have not yet been scientifically studied. In brief, several plants can be indicated for more detailed study, with a view to obtain scientific subsidies for a new and effective diuretic medicine in the future. These include Bauhinia forficata, Leandra dasytricha, and Tropaeolum majus. Other species have reputed medicinal properties but lack experimental assays to demonstrate their pharmacological effects (e.g., Mikania hirsutissima, Phyllanthus niruri, and Tagetes minuta). Several active principles are indicated as responsible for the diuretic effects of the plants studied, with emphasis on phenolic compounds as flavonoids, phenolic acids, and xanthones. These results should encourage more detailed preclinical, clinical, and phytochemical investigations on Brazilian plants in the future.

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“…The chemical characterization of the ESTP used in this study was recently described by Tolouei and collaborators. 3…”

Section: Methodsmentioning

confidence: 99%

“…Animals were treated by oral gavage from PND 23 to PND 53 with two doses of ESTP (30 and 300 mg/kg), vehicle (filtered water, 5 ml/kg), di (2-ethylhexyl) phthalate (DEHP 750 mg/kg, male positive control), or 17α-ethinylestradiol (3 μg/kg, female positive control). The ESTP doses were based on a previous study performed by Tolouei et al 3 The DEHP dose was based on previous studies performed by Kita et al 13 and Venturelli et al, 14 while the 17α-ethinylestradiol dose was chosen on the basis of recent uterotrophic assays conducted in our laboratory (unpublished).…”

Section: Methodsmentioning

confidence: 99%

Effects of Talinum paniculatum (Jacq.) Gaertn. leaf extract on general toxicity and pubertal development of rats

et al. 2020

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Talinum paniculatum (Jacq.) Gaertn. (Talinaceae), popularly known as “major gomes,” is a Brazilian Cerrado plant used in traditional medicine and as a food source. Recent studies have demonstrated its diuretic effects. However, no studies have been performed on its effects on the reproductive system. Therefore, we aimed to investigate the effects of the ethanol-soluble fraction of T. paniculatum leaves (ESTP) on general toxicity and on the pubertal development of male and female Wistar rats. For this purpose, the uterotrophic and the pubertal assays were performed. In the uterotrophic test, female immature rats were treated for three consecutive days with 30, 100, or 300 mg/kg of ESTP. Uterus without luminal fluid was weighed and the relative weight calculated. For the pubertal assay, male and female immature rats were submitted to 30-day treatment with 30 or 300 mg/kg of ESTP. Clinical signs of toxicity, biochemical, and histopathological parameters were evaluated. ESTP treatment did not promote estrogenic effects in female rats. In the pubertal test, no daily signs of toxicity or weight loss were observed. Moreover, ESTP did not affect the onset of vaginal opening and preputial separation and did not cause significant changes in biochemical parameters as well as in organ weight and histopathological analyses of animals.

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Ethnopharmacological approaches to Talinum paniculatum (Jacq.) Gaertn. - Exploring cardiorenal effects from the Brazilian Cerrado

Cited by 23 publications

References 33 publications

Anatomy, micromorphology, and histochemistry of leaves and stems of Cantinoa althaeifolia (Lamiaceae)

Anatomy, micromorphology, and histochemistry of leaves and stems of Cantinoa althaeifolia (Lamiaceae)

Promising Medicinal Plants with Diuretic Potential Used in Brazil: State of the Art, Challenges, and Prospects

Effects of Talinum paniculatum (Jacq.) Gaertn. leaf extract on general toxicity and pubertal development of rats

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