Effects of Talinum paniculatum (Jacq.) Gaertn. leaf extract on general toxicity and pubertal development of rats

Abstract

Talinum paniculatum (Jacq.) Gaertn. (Talinaceae), popularly known as “major gomes,” is a Brazilian Cerrado plant used in traditional medicine and as a food source. Recent studies have demonstrated its diuretic effects. However, no studies have been performed on its effects on the reproductive system. Therefore, we aimed to investigate the effects of the ethanol-soluble fraction of T. paniculatum leaves (ESTP) on general toxicity and on the pubertal development of male and female Wistar rats. For this purpose, the uterotrophic and the pubertal assays were performed. In the uterotrophic test, female immature rats were treated for three consecutive days with 30, 100, or 300 mg/kg of ESTP. Uterus without luminal fluid was weighed and the relative weight calculated. For the pubertal assay, male and female immature rats were submitted to 30-day treatment with 30 or 300 mg/kg of ESTP. Clinical signs of toxicity, biochemical, and histopathological parameters were evaluated. ESTP treatment did not promote estrogenic effects in female rats. In the pubertal test, no daily signs of toxicity or weight loss were observed. Moreover, ESTP did not affect the onset of vaginal opening and preputial separation and did not cause significant changes in biochemical parameters as well as in organ weight and histopathological analyses of animals.

A Review on Bioactive Compounds, Ethnomedicinal Importance and Pharmacological Activities of Talinum triangulare (Jacq.) Willd

“…It is widely distributed in various geographical regions of Asia, East Asia, and Southern America [66,67] . It is also found in the areas near the Amazon River inBrazil, [41,68] Mexico, the Caribbean islands, Central America, [25] Cameroon, Indonesia [1] and China [26,69] …”

The Effect of Callus Age on Biomass and Flavonoid Production in Talinum paniculatum In Vitro Culture

“…T.paniculatum has known for several important bioactive compounds such as saponin, flavonoid, tannin, and steroid (Aini & Susilo, 2023). This plant has several pharmacological effects including antioxidant (Lestario dkk., 2009), anti-cancer (Liu et al, 2018), anti-diabetic (Jenie & Indraswari, 2021), anti-microbial (Cerdeira et al, 2020), to treat cardiovascular and urinary tract diseases (Tolouei et al, 2021) and to enhance spermatozoa motility and viability (Aini & Susilo, 2023). Flavonoid is one of the prominent bioactive compounds that are contained in all parts of T.paniculatum and has been known to its several bioactivities, including antioxidant, antiinflammatory, antimicrobial, antidiabetic and anti-cancer (Eddijanto et al, 2022).…”

A newly identified β-amyrin synthase gene hypothetically involved in oleanane-saponin biosynthesis from Talinum paniculatum (Jacq.) Gaertn.

“…This plant leaf is commonly consumed as a vegetable supplement and the roots are used as a reproductive tonic in Thailand's traditional practice [ 1 ]. In addition , T. paniculatum or “major gomes” and “erva gorda” in Brazil is consumed and used to treat different cardiovascular disorders in folk medicine [ 2 ]. Further study to confirm the ethnomedicine of this plant extract exhibited the estrogenic activity [ 1 ], diuretic effect after prolonged exposure [ 2 ], and cardioprotective effects through serum antioxidant activity and ACE inhibition, preventing alterations of hemodynamic and endothelial function, and reducing damage to cardiac structure in a rat model [ 3 ].…”

“…In addition , T. paniculatum or “major gomes” and “erva gorda” in Brazil is consumed and used to treat different cardiovascular disorders in folk medicine [ 2 ]. Further study to confirm the ethnomedicine of this plant extract exhibited the estrogenic activity [ 1 ], diuretic effect after prolonged exposure [ 2 ], and cardioprotective effects through serum antioxidant activity and ACE inhibition, preventing alterations of hemodynamic and endothelial function, and reducing damage to cardiac structure in a rat model [ 3 ]. This plant is classified as Unconventional Food Plants (UFP) because of the nutritional value of the leaves.…”