Ethnobotanical survey and in vitro antiplasmodial activity of plants used in traditional medicine in Burkina Faso

Sanon, Souleymane; Ollivier, Évelyne; Azas, Nadine; Mahiou, Valérie; Gasquet, M.; Ouattara, C.T; Nébié, Issa; Traoré, Abdoulaye; Esposito, Fulvio; Balansard, G.; Timon‐David, P.; Fumoux, Francis

doi:10.1016/s0378-8741(02)00381-1

Cited by 113 publications

(84 citation statements)

References 9 publications

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“…The aqueous extract was also inactive, confirming previous studies which demonstrated the lack of antimalarial effect of the aqueous extract of this plant. (Bero et al, 2009;Sanon et al, 2003b). In these studies, the dichloromethane extract was 270-276 http://dx.doi.org/10.4314/ajtcam.v10i2.11…”

Section: Discussionmentioning

confidence: 99%

In vitro evaluation of antiplasmodial activity of extracts of Acanthospermum hispidum dc (Asteraceae) and Ficus thonningii blume (moraceae), two plants used in traditional medicine in the republic of Congo

Koukouikila-Koussounda¹,

Abena²,

Nzoungani³

et al. 2013

Afr. J. Trad. Compl. Alt. Med.

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The aim of this study was to evaluate extracts from two medicinal plants, Acanthospermum hispidum and Ficus thonningii, used in traditional medicine in Congo Brazzaville, for in vitro antiplasmodial activities against two laboratory strains of Plasmodium falciparum: the chloroquine sensitive 3D7 and the chloroquine resistant Dd2. ELISA HRP2 assay was used to evaluate the in vitro inhibitory activity of the extracts alone or in combination with chloroquine. Cytotoxicity was assessed on human HeLa cell line and reflected by the selectivity index. Methanolic extract of Acanthospermum hispidum exhibited a strong and a moderate inhibitory activity on the growth of Dd2 and 3D7 at 2.8 µg/ml and 9.2 µg/ml concentrations respectively with a selectivity index >10. The combination of the most active extract (methanolic extract of Acanthospermum hispidum) with chloroquine showed a synergistic interaction on both strains. The good selectivity index of Acanthospermum hispidum on HeLa cells reflects the safety of this plant. Extracts from Ficus thonningii did not show any promising antiplasmodial activity on both 3D7 and Dd2. Except the methanolic extract which exhibited a slight antiplasmodial activity with inhibitory concentration and selectivity index corresponding to 9.61 µg/ml and 11.16 respectively. Methanolic extract of Acanthospermum hispidum exhibited moderate to high inhibitory activity on 3D7 and Dd2 laboratory strains and a synergistic antimalarial effect when combined with chloroquine. Ficus thonningii seems to have no antimalarial activity. Phytochemical analysis, in vivo investigations using animal models and later clinical trials in collaboration with traditional practitioners are necessary to clarify the potential antimalarial activity of both plants.

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Section: Discussionmentioning

confidence: 99%

In vitro evaluation of antiplasmodial activity of extracts of Acanthospermum hispidum dc (Asteraceae) and Ficus thonningii blume (moraceae), two plants used in traditional medicine in the republic of Congo

Koukouikila-Koussounda¹,

Abena²,

Nzoungani³

et al. 2013

Afr. J. Trad. Compl. Alt. Med.

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“…After cooling, solutions were filtered on cotton wool and freeze-dried. Crude alkaloid extracts were obtained by alkalization with 28% NH4OH to pH9 of the plant powder and extraction with CH2Cl2 for 24 h. Plant powder (10 g) was used by applying the classical alkaloids extraction method (Sanon et al, 2003). After 16 h of maceration with ammoniac and CH2Cl2, a percolation was made with CH2Cl2 solvent.…”

Section: Preparation Of Plant Extractsmentioning

confidence: 99%

Antiplasmodial activity of Vernonia cinerea Less (Asteraceae), a plant used in traditional medicine in Burkina Faso to treat malaria

Soma¹,

Sanon²,

GansanÃ³

et al. 2017

Afr. J. Pharm. Pharmacol.

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Research and development of new antiplasmodial molecules in plant is a very important way for the development of new anti-malarial drugs. In this study, Vernonia cinerea Less (Asteraceae) was selected for its promising antiplasmodial activity because it is traditionally used in Burkina Faso to treat malaria. The aim of this study was to investigate the antiplasmodial activity of this whole plant. Five crude extracts of V. cinerea Less were prepared from the solvents of increasing polarity (CH 2 Cl 2 , CH 3 OH, CH 3 OH/H 2 O (1/1), H 2 O and alkaloids extracts). The method of Ciulei (1982) and thin layer chromatography were used for chemical characterization. The p-LDH technique was used in vitro. Extracts were evaluated in vitro for efficacy against the Plasmodium falciparum strain K1, which is resistant to chloroquine, and 3D7, which is sensitive to chloroquine. The crude extracts of alkaloids showed the IC 50 =4.25 μg/ml with the strains 3D7 and IC 50 =2.56 µg/ml with the K1 strains. The CH 2 Cl 2 extracts showed the IC 50 = 8.42 µg/ml and IC 50 =5.85 µg/ml on strains 3D7 and K1, respectively. The CH 3 OH extracts showed the IC 50 =21.08 µg/ml, CH 3 OH/H 2 O extracts gave 41.56 µg/ml and H 2 O extracts gave 37.17 µg/ml on strains of P. falciparum K1. The present study highlighted the very promising antiplasmodial activity of V. cinerea Less. The most antiplasmodial activity of this plant extracts merit further study about its in vivo antiplasmodial activity in Plasmodium berghei infected mice.

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“…69,70) Recently, we have isolated two novel heteroaromatic alkaloids, cassiarin A (91) and cassiarin B (92), from the leaves of Cassia siamea (Leguminosae) (Fig. 3).…”

Section: )mentioning

confidence: 99%

Investigation of Innovative Synthesis of Biologically Active Compounds on the Basis of Newly Developed Reactions

Honda

2012

CHEMICAL & PHARMACEUTICAL BULLETIN

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Synthesis of biologically active compounds, including natural products and pharmaceutical agents, is an important and interesting research area since the large structural diversity and complexity of bioactive compounds make them an important source of leads and scaffolds in drug discovery and development. Many structurally and also biologically interesting compounds, including marine natural products, have been isolated from nature and have also been prepared on the basis of a computational design for the purpose of developing medicinal chemistry. In order to obtain a wide variety of derivatives of biologically active compounds from the viewpoint of medicinal chemistry, it is essential to establish efficient synthetic procedures for desired targets. Newly developed reactions should also be used for efficient synthesis of desired compounds. Thus, recent progress in the synthesis of biologically active compounds by focusing on the development of new reactions is summarized in this review article.

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Ethnobotanical survey and in vitro antiplasmodial activity of plants used in traditional medicine in Burkina Faso

Cited by 113 publications

References 9 publications

<i>In vitro</i> evaluation of antiplasmodial activity of extracts of <i>Acanthospermum hispidum</i> dc (Asteraceae) and <i>Ficus thonningii</i> blume (moraceae), two plants used in traditional medicine in the republic of Congo

<i>In vitro</i> evaluation of antiplasmodial activity of extracts of <i>Acanthospermum hispidum</i> dc (Asteraceae) and <i>Ficus thonningii</i> blume (moraceae), two plants used in traditional medicine in the republic of Congo

Antiplasmodial activity of Vernonia cinerea Less (Asteraceae), a plant used in traditional medicine in Burkina Faso to treat malaria

Investigation of Innovative Synthesis of Biologically Active Compounds on the Basis of Newly Developed Reactions

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