Investigation of Innovative Synthesis of Biologically Active Compounds on the Basis of Newly Developed Reactions

Abstract

Synthesis of biologically active compounds, including natural products and pharmaceutical agents, is an important and interesting research area since the large structural diversity and complexity of bioactive compounds make them an important source of leads and scaffolds in drug discovery and development. Many structurally and also biologically interesting compounds, including marine natural products, have been isolated from nature and have also been prepared on the basis of a computational design for the purpose of developing medicinal chemistry. In order to obtain a wide variety of derivatives of biologically active compounds from the viewpoint of medicinal chemistry, it is essential to establish efficient synthetic procedures for desired targets. Newly developed reactions should also be used for efficient synthesis of desired compounds. Thus, recent progress in the synthesis of biologically active compounds by focusing on the development of new reactions is summarized in this review article.

Assessment of Conjugate Complexes of Chitosan and Urtica dioica or Equisetum arvense Extracts for the Control of Grapevine Trunk Pathogens

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Annona muricata L.-Derived Polysaccharides as a Potential Adjuvant to a Dendritic Cell-Based Vaccine in a Thymoma-Bearing Model

“…Adjuvant candidates include chemically and biologically active compounds such as microbial substances, mineral salts, emulsions, pharmaceutical agents, or natural products [ 12 , 13 , 14 ]. Among these candidates, natural products extracted or isolated from plants are now attracting attention due to many advantages, such as their availability and affordability, and minimal or no side effects [ 13 , 15 , 16 , 17 ].…”

Development of a design research for determining the quality indicators of potential API. 1. newly synthesized substances for primary pharmacological screening

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