Ethnicity determines association of p53Arg72Pro alleles with cervical cancer in China

Cervical cancer develops through progression from normal cervical epithelium through squamous intraepithelial lesions (SIL) to invasive cancer. Cervical cancer is associated with oncogenic human papillomavirus (HPV). The HPV E6 oncoprotein binds to the tumor suppressor gene product p53, promoting its degradation; the Arg allele of p53 Arg72Pro polymorphism binds more ardently with HPV E6 than the Pro variant. Here we evaluate the role of p53 Arg72Pro polymorphism and HPV status on the initiation, progression, and development of cervical cancer. A systematic review and meta-analysis were conducted. Events of interest were the initiation of neoplasia (SIL vs. normal), progression to invasive cancer (cervical cancer vs. SIL), and risk of invasive cancer (cervical cancer vs. normal) by HPV status. OR were extracted from individual studies and pooled using generic inverse variance and random effects modeling. Forty-nine studies were included. In individuals showing HPV positivity, there was a significantly higher odds of progression from SIL to cervical cancer with the p53 Arg allele [OR 1.37; 95% confidence intervals (CI), 1.15-1.62; P < 0.001]. This association was not seen in HPVnegative individuals. p53 Arg72Pro was not associated with the risk of cervical cancer or initiation of SIL in either HPV-positive or HPV-negative patient subsets. The Arg variant of p53 Arg72Pro is associated with progression of SIL to cervical cancer only in the presence of HPV positivity. There were no associations of this variant with overall risk or initiation of cancer in either HPV-positive or HPVnegative patients.

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“…S1). Two publications reported results for 2 independent populations (18,19). These were assessed as 2 separate studies.…”

Section: Resultsmentioning

confidence: 99%

p53 Arg72Pro Polymorphism, HPV Status and Initiation, Progression, and Development of Cervical Cancer: A Systematic Review and Meta-Analysis

Habbous

Pang

Eng

et al. 2012

Clinical Cancer Research

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“…According to the inclusion criteria, 28 studies (Minaguchi et al, 1998;Ngan et al, 1999;Baek et al, 2000;Kim et al, 2000;Kim et al, 2001;Yang et al, 2001;Bhattacharya et al, 2002;Kawamata et al, 2002;Nagpal et al, 2002;Saranath et al, 2002;Xi et al, 2002;Cho et al, 2003;Katiyar et al, 2003;Cho et al, 2004;Lee et al, 2004;Li et al, 2004;Wang et al, 2004;Wu et al, 2004;Yoshimitsu et al, 2004;Masatsugu et al, 2005;Mitra et Yao et al, 2008;Zheng et al, 2008;Zhou et al, 2009) were included and 103 were excluded in this meta-analysis. The flow chart of study selection is shown in Figure 1.…”

Section: Studies Included In the Meta-analysismentioning

confidence: 99%

Association Between p53 codon 72 Polymorphism and Cervical Cancer Risk Among Asians: a Huge Review and Meta-analysis

Zhou¹,

Gu²,

Zhang³

2012

Asian Pacific Journal of Cancer Prevention

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“…The Xinjiang region of China shows a high incidence of cervical cancer, and Uyghur women in particular exhibit a significantly high risk of cervical cancer. The prevalence of cervical cancer is significantly higher in Uyghur women than that in any other ethnic group; the incidence of cervical cancer among Uyghur women in Xinjiang has been reported to be 459/100,000–527/100,000, which is significantly higher than the incidence in any other region of China [ 4 – 6 ]. Multiple factors, such as human papillomavirus (HPV) infection, marriage and childbearing, contribute to the high incidence of cervical cancer among this population [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Factors associated with high-risk HPV infection and cervical cancer screening methods among rural Uyghur women aged > 30 years in Xinjiang

et al. 2018

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BackgroundCervical cancer is the most common genital malignant tumor in women worldwide. However, the reliability of different detection methods may vary according to populations and epidemics. This study analyzed factors relevant to high-risk human papillomavirus (hrHPV) infection among rural Uyghur women aged > 30 years and evaluated the value of different screening methods for cervical precancerous lesions.MethodsFrom July 2015 to May 2016, 225 rural Uyghur women aged > 30 years were recruited from local health clinics throughout Pishan, Xinjiang, China. HrHPV DNA testing, colposcopy, biopsy of cervical precancerous lesions, and surveys were conducted. The results of different screening methods were compared, and factors associated with hrHPV infection were analyzed.ResultsThe rates of hrHPV infection and cervical epithelial lesions were 9.3 and 1.8%, respectively. The area under the ROC curve was 0.538 (95% CI: 0.292, 0.784; P = 0.753) for the HPV test and 0.995 (95% CI: 0.988, 1.003; P < 0.001) for colposcopy. Factors associated with HPV infection included widowhood (OR = 13.601 (2.170, 85.263), P = 0.005) and ≥ 3 sexual partners in the past 5 years (OR = 16.808 (4.148, 68.101), P < 0.001). .ConclusionsAmong rural Uyghur women aged > 30 years, the main factors for HPV infection include marriage and frequent sexual intercourse. Colposcopy has a higher screening value for cervical epithelial lesions than hrHPV testing.

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Ethnicity determines association of p53Arg72Pro alleles with cervical cancer in China

Cited by 10 publications

References 16 publications

p53 Arg72Pro Polymorphism, HPV Status and Initiation, Progression, and Development of Cervical Cancer: A Systematic Review and Meta-Analysis

p53 Arg72Pro Polymorphism, HPV Status and Initiation, Progression, and Development of Cervical Cancer: A Systematic Review and Meta-Analysis

Association Between p53 codon 72 Polymorphism and Cervical Cancer Risk Among Asians: a Huge Review and Meta-analysis

Factors associated with high-risk HPV infection and cervical cancer screening methods among rural Uyghur women aged > 30 years in Xinjiang

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