Factors associated with high-risk HPV infection and cervical cancer screening methods among rural Uyghur women aged > 30 years in Xinjiang

Abstract

BackgroundCervical cancer is the most common genital malignant tumor in women worldwide. However, the reliability of different detection methods may vary according to populations and epidemics. This study analyzed factors relevant to high-risk human papillomavirus (hrHPV) infection among rural Uyghur women aged > 30 years and evaluated the value of different screening methods for cervical precancerous lesions.MethodsFrom July 2015 to May 2016, 225 rural Uyghur women aged > 30 years were recruited from local health clinics throughout Pishan, Xinjiang, China. HrHPV DNA testing, colposcopy, biopsy of cervical precancerous lesions, and surveys were conducted. The results of different screening methods were compared, and factors associated with hrHPV infection were analyzed.ResultsThe rates of hrHPV infection and cervical epithelial lesions were 9.3 and 1.8%, respectively. The area under the ROC curve was 0.538 (95% CI: 0.292, 0.784; P = 0.753) for the HPV test and 0.995 (95% CI: 0.988, 1.003; P < 0.001) for colposcopy. Factors associated with HPV infection included widowhood (OR = 13.601 (2.170, 85.263), P = 0.005) and ≥ 3 sexual partners in the past 5 years (OR = 16.808 (4.148, 68.101), P < 0.001). .ConclusionsAmong rural Uyghur women aged > 30 years, the main factors for HPV infection include marriage and frequent sexual intercourse. Colposcopy has a higher screening value for cervical epithelial lesions than hrHPV testing.

ThinPrep cytology combined with HPV detection in the diagnosis of cervical lesions in 1622 patients

“…However, our result was lower than that of samples with abnormal cytological outcomes collected at the Affiliated Hospital of Xinjiang Medical University [ 25 ]. In addition, this study showed that the cervical cancer detection rate was 1.48%, which was higher than that reported by Husaiyin et al (who conducted cervical cancer examinations in Pishan County) [ 26 ] and by Han et al (whose study was conducted in Urumqi) [ 27 ]. Different sample sources could account for these inconsistencies.…”

Epidemiological and Cytopathological Profile of Dysplastic Lesions of the Cervix in South-Kivu/Dr Congo

“…Arora R et al [33] found 45% of illiterates in India, which is higher than that of our series, while Gordon JR et al [22] observed, still in India, several years later a rate of 8 % illiterate, which is far inferior to ours. Husaiyin S et al [25] reported in China a rate, higher than ours, of 68.0% of women with no more than primary education, while Tapera O et al [26] found a higher rate in Zimbabwe than women in our series, of women with a high school education (71%).…”

“…OR adjusted (95% CI) factors associated with dysplastic lesions. Open Journal of Obstetrics and Gynecology Several other studies have been done and have shown the predominance of married women in case of dysplastic lesions of the cervix[25]-[30].…”

Prevalence of human papillomavirus genotypes and precancerous cervical lesions in a screening population in Beijing, China: analysis of results from China’s top 3 hospital, 2009–2019

“…In this study, HPV16 had the highest prevalence amongst different levels of cervical precancerous lesions: HSIL (56.46%, 926/1640); LSIL (24.18%, 289/1195); Normal (40%, 8/20). In other studies, HPV16 was also the most common type in patients with precancerous neoplasia lesions both in Pishan county, Shenyang city, Shenzhen city and other provinces in China [ 22 – 24 ] and worldwide [ 15 , 25 , 26 ]. However, some other studies found that HPV52 was the most common genotype in rural North China [ 27 ] and Jiangsu, Guangdong and other provinces in China [ 28 , 29 ].…”