Estrogen Receptor Alpha mRNA in Human Skeletal Muscles

Lemoine, Sophie; Granier, P.; Tiffoche, Christophe; Rannou-Bekono, Françoise; Thieulant, Marie-Lise; Delamarche, Paul

doi:10.1249/01.mss.0000053654.14410.78

Cited by 170 publications

(133 citation statements)

References 23 publications

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“…Soy isoflavones, acting as phytoestrogens, may have a positive effect on muscle mass because of their affinity for estrogen receptor-␣, which is found on muscle [21], or may exert their effects on reducing inflammation [22][23][24] associated with muscle protein degradation [25][26][27][28]. Besides soy isoflavones, other soy constituents such as protein may affect muscle mass [29].…”

Section: Discussionmentioning

confidence: 99%

Legumes and soy products consumption and functional disability in older women

Kim

Lee

2011

Maturitas

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Section: Discussionmentioning

confidence: 99%

Legumes and soy products consumption and functional disability in older women

Kim

Lee

2011

Maturitas

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“…7 Estrogens also act through cell membrane located receptors, which can be independent of ESRs. 8 ESRs have been found in human skeletal muscle 9,10 suggesting the contribution of estrogens to muscle functions. Recent experimental animal studies have provided evidence that estrogen, via its receptors, has a role in glucose metabolism in muscle 11,12 .…”

Section: Introductionmentioning

confidence: 99%

Muscular Transcriptome in Postmenopausal Women With or Without Hormone Replacement

Pöllänen

Ronkainen

Suominen

et al. 2007

Rejuvenation Research

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The loss of muscle mass and strength with aging is well characterized, but our knowledge of the molecular mechanisms underlying the development of sarcopenia remains incomplete. Although menopause is often accompanied with first signs of age-associated changes in muscle structure and function, the effects of hormone replacement therapy (HRT) or menopause-related decline in estrogen production in the muscles of postmenopausal women is not well understood.Furthermore the knowledge of the global transcriptional changes that take place in skeletal muscle in relation to estrogen status has thus far been completely lacking. We used a randomized double-blinded study design together with an explorative microarray experiment to characterize possible effects of continuous, combined HRT and estrogen deprivation on the skeletal muscle of fifteen women. Here, we report the differential response of both GO-annotated biological processes and some individual genes responding differentially to the use or non-use of HRT. Our results revealed transcription level changes in, e.g., muscle protein and energy metabolism. In particular, the ubiquitine-proteosome system was found to be effected at several levels. HRT seemed to partially counteract the postmenopause-related transcriptional changes. Our results suggest that during the early postmenopausal years, when there is no counteracting medication available, muscle transcriptome changes notably, whereas HRT appears to slow-down this phenomenon and could therefore aid in maintaining proper muscle mass and function after menopause.3

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“…The effect of estrogen is delivered by estrogen receptors (ERs), localized in the nucleus or on the cell membranes. ERs are also found in the skeletal muscle cells, making skeletal muscle tissue responsive to estrogens (Lemoine, et al 2003, Wiik, et al 2005). There are indications that dramatically decreasing level of circulating 17β-estradiol (E 2 ) at the time of menopause contributes to age-associated muscle weakness (Phillips, et al 1993, Sipila, et al 2001.…”

Section: Introductionmentioning

confidence: 99%