Estado nutricional, alterações metabólicas e células brancas na adolescência1

Abstract

OBJECTIVE: To analyze the relationship between the peripheral blood white cells, metabolic changes, and nutritional status of adolescents with and without excess weight and body fat. METHODS: This cross-sectional study evaluated the body mass index (BMI) and percentage body fat (%BF) in 362 adolescents from 15 to 19 years of age, of both sexes. White blood cell count, platelet count, uric acid, fasting glucose, insulin, and lipid profile were measured. The inclusion criteria were agreement to participate in the study and signature of the informed consent. Exclusion criteria were: presence of chronic or infectious disease; use of medications that could cause changes in biochemical tests; pregnancy; participation in weight reduction and weight control programs; use of diuretics and laxatives; or the presence of a pacemaker. The following statistical tests were applied: Kolmogorov-Smirnov test, Student's t or Mann-Whitney test, Pearson or Spearman correlation tests, and chi-squared test, considering p<0.05. RESULTS: Overweight was observed in 20.7% of adolescents. The total cholesterol (TC) had a higher percentage of inadequacy (52.2%), followed by high-density lipoprotein (HDL) (38.4%). There was a positive correlation between white cells and serum lipids, insulin, body fat, and BMI. Monocytes were negatively correlated with BMI, and rods with BMI, body fat, and insulin. CONCLUSIONS: Nutritional status is related to an inflammatory process, and adolescents with excess weight or body fat presented higher amounts of white blood cells.

Dyslipidemia in Adolescents Seen in a University Hospital in the city of Rio de Janeiro/Brazil: Prevalence and Association

“…In the study by Garcez MR et al, 20 it was observed that overweight adolescents had higher mean values for TC, LDL-c and TG, as well as low HDL-c, as in this study. 20 Similarly, Oliveira et al 24 found such results when they assessed the lipid profile according to the nutritional status. 24 The main changes that are usually associated with obesity in this age group, and which have been observed as the standard are changes in HDL-c and TG.…”

“…20 Similarly, Oliveira et al 24 found such results when they assessed the lipid profile according to the nutritional status. 24 The main changes that are usually associated with obesity in this age group, and which have been observed as the standard are changes in HDL-c and TG. 25,26 This study demonstrated an association between HDL-c/TG and WC/BMI, showing the relationship with adiposity.…”

“…23 Although no significant difference between the lipid profile means within the genders was observed, it is possible to notice that the girls had higher values for all parameters, and this is commonly observed in the literature. 19,22,24…”

Changes in leukocyte profile and C-reactive protein concentration in overweight and obese adolescents after reduction of body weight

“…Our study confirmed previous observations that accumulation of fat mass leads to development of low-grade systemic inflammation. Overweight and obese children had a higher peripheral total leukocyte count compared to their lean peers [9, 10, 29]. It is mainly related to the elevated monocyte count [7].…”

“…Overweight and obese patients have a higher total leukocyte count compared to their lean peers, which is mostly the result of the increase in the monocyte count [7]. Neutrophil, lymphocyte and eosinophil counts may also be elevated [8-10]. Greater adiposity leads to a higher CRP level [1, 8, 11-13].…”