Changes in leukocyte profile and C-reactive protein concentration in overweight and obese adolescents after reduction of body weight

Rumińska, Małgorzata; Witkowska–Sędek, Ewelina; Artemniak-Wojtowicz, Dorota; Krajewska, Maria; Majcher, Anna; Sobol, Maria; Pyrżak, Beata

doi:10.5114/ceji.2019.89608

Cited by 11 publications

(11 citation statements)

References 30 publications

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“…In this way, chronic inflammation has emerged as one of the key physiological mechanisms that links obesity with different associated pathologies, such as diabetes, cardiovascular disease, cancer, and asthma; thus, it is important to determine the presence of inflammation in a population. In particular, obesity has been linked to high CRP levels [87][88][89] and changes in the leukocyte profile [90,91]. In addition, according to our results, in a study carried out in 26,016 middle-aged and older adults (>35 years old) with metabolic syndrome in Taiwan, obesity, high body fat, high WC or hip circumference, and high WHtR were significantly associated with increased odds ratios of high CRP and NLR [12].…”

Section: Discussionsupporting

confidence: 67%

Association between Neutrophil-to-Lymphocyte Ratio with Abdominal Obesity and Healthy Eating Index in a Representative Older Spanish Population

et al. 2020

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Poor diet quality and obesity, especially abdominal obesity, have been associated with systemic inflammation. The neutrophil-to-lymphocyte Ratio (NLR) is an available and inexpensive inflammation biomarker. The aim of the present study was to determine the association of dietary patterns and obesity with an inflammatory state. A group of 1747 Spanish noninstitutionalized older adults individuals were included, and a food-frequency questionnaire was applied. The Global Food Score (GFS) and Healthy Eating Index for Spanish population (SHEI) were calculated. Weight, height and waist (WC) and hip circumferences were measured, and BMI, waist-to-height ratio (WHtR), and waist-to-hip ratio (WHR) determined. In addition, body-fat percentage was measured by bioimpedance. NLR was calculated (NLR ≥ p80: 2.6; 2.8 and 2.4 as inflammatory status in the entire population, men and women, respectively). The men with inflammatory status presented significative higher values of WC, WHtR, WHR, and body-fat percentage (101.82 ± 10.34 cm, 0.61 ± 0.06, 0.98 ± 0.06, and 31.68 ± 5.94%, respectively) than those with better inflammatory status (100.18 ± 10.22 cm, 0.59 ± 0.06, 0.97 ± 0.07, and 30.31 ± 6.16%, respectively). Those males with worse inflammatory state had lower scores for protein foods (OR = 0.898 (0.812–0.993); p = 0.037). The women with NLR ≥ 2.4 had higher WHtR and WHR (0.62 ± 0.09 and 0.91 ± 0.09) than those with NLR < 2.4 (0.60 ± 0.08 and 0.90 ± 0.08). In multiple linear regression analysis, NLR was positively related with WHtR and negatively related with SHEI score (β = 0.224 ± 0.094; R2 = 0.060; p < 0.05 and β = −0.218 ± 0.101; R2 = 0.061; p < 0.05), adjusting by sex, age, marital status, education level, smoking, hours of sleeping and inflammatory diseases. In women, the higher the SHEI and GFS scores were and the better meeting the aims of cereal and vegetable servings, the less the odds of inflammatory status (OR = 0.970 (0.948–0.992); p = 0.008; OR = 0.963 (0.932–0.995); p = 0.024; OR = 0.818 (0.688–0.974); p = 0.024 and OR = 0.829 (0.730–0.942); p = 0.004, respectively). WHtR and quality of diet is related to the inflammation status in older adults regardless to the sex.

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Section: Discussionsupporting

confidence: 67%

Association between Neutrophil-to-Lymphocyte Ratio with Abdominal Obesity and Healthy Eating Index in a Representative Older Spanish Population

et al. 2020

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“…Similar results were presented in our previously published study which considered almost 100 overweight and obese children. Our previous research indicated that WBC and granulocyte count were related to BMI SDS, while monocyte count was related to waist circumference, which could suggest that visceral adipose tissue has much greater pro-inflammatory potential than subcutaneous tissue, as a source of pro-inflammatory adipokines and cytokines ( 36 ).…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, pro-inflammatory cytokines could affect systemic inflammation by enhancing liver production of acute phase markers including fibrinogen and C-reactive protein (CRP) and by activating granulocyte and monocyte progenitor cells ( 29 – 32 ). Higher blood leukocyte, lymphocyte, granulocyte, eosinophil, and monocyte count is well documented in obese individuals ( 33 – 36 ).…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Effects on Selected Anti-Inflammatory and Pro-Inflammatory Markers of Obesity-Related Chronic Inflammation

et al. 2022

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BackgroundObesity is related to changes in adipokine secretion, activity of adipose tissue macrophages, helper T cells, and regulatory T cells. It has been confirmed that vitamin D has potent anti-inflammatory properties. It contributes to reduction in pro-inflammatory mediators and an increase in anti-inflammatory cytokines. There is also evidence that vitamin D could decrease C-reactive protein (CRP) and affect selected haematological indices.Aim of the StudyWe aimed to evaluate the effect of vitamin D on interleukin (IL)-10, IL-17, CRP, blood leukocyte profile, and platelet (PLT) count in overweight and obese children before and after six months of vitamin D supplementation.Material and MethodsThe study group consisted of 67 overweight and obese children aged 9.08-17.5 years. The control group included 31 normal weight peers age- and sex-matched. None of the studied children had received vitamin D supplementation before the study. Data were analyzed at baseline and after vitamin D supplementation.ResultsThe study group had lower baseline 25(OH)D (p<0.001) and higher white blood cell (WBC) (p=0.014), granulocyte (p=0.015), monocyte (p=0.009) and CRP (p=0.002) compared to the control group. In the study group, vitamin D levels were related negatively to nutritional status. Leukocyte profile parameters, PLT, CRP, IL-10 or IL-17 were not related to baseline 25(OH)D. Baseline IL-17 levels correlated with monocytes (R= 0.36, p=0.003) independently on 25(OH)D deficit. In children with vitamin D <15ng/ml, the baseline 25(OH)D was related to CRP (R=-0.42, p=0.017). After six months of vitamin D supplementation, we noticed a decrease in CRP levels (p=0.0003). Serum 25(OH)D correlated with IL-10 in that period (R=0.27, p=0.028). Moreover, we noticed that IL-10 correlated with monocyte (R=-0.28, p=0.023). We did not find any significant associations between 25(OH)D and leukocyte profile parameters, PLT, or IL-17. The multivariable stepwise regression analysis identified IL-10 as the parameter positively associated with 25(OH)D.ConclusionsOur study confirmed beneficial effects of vitamin D supplementation in overweight and obese paediatric populations. Vitamin D intake seems to exert its anti-inflammatory effect mainly via decreasing the CRP level and protecting stabile values of IL-10, rather than its impact on pro-inflammatory factors such as lL-17 and leukocyte profile parameters.

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“…An increased level of CRP is widely observed in obese humans. In study in overweight children, the CRP concentration was significantly elevated, compared to normal weight children [ 36 ] and correlates positively with body weight and BMI [ 37 ]. CRP is synthesized and secreted primarily in human hepatocytes, and its synthesis is regulated mainly by IL-6 and IL-1.…”

Section: C-reactive Protein (Crp)mentioning

confidence: 99%

Obesity and chronic inflammation crosslinking

Artemniak-Wojtowicz¹,

Kucharská²,

Pyrżak³

2020

cejoi

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Changes in leukocyte profile and C-reactive protein concentration in overweight and obese adolescents after reduction of body weight

Cited by 11 publications

References 30 publications

Association between Neutrophil-to-Lymphocyte Ratio with Abdominal Obesity and Healthy Eating Index in a Representative Older Spanish Population

Association between Neutrophil-to-Lymphocyte Ratio with Abdominal Obesity and Healthy Eating Index in a Representative Older Spanish Population

Vitamin D Effects on Selected Anti-Inflammatory and Pro-Inflammatory Markers of Obesity-Related Chronic Inflammation

Obesity and chronic inflammation crosslinking

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