Essential Oil Composition of Some Sage (Salvia spp.) Species Cultivated in İzmir (Turkey) Ecological Conditions

Karik, Ünal; ÇINAR, Orçun; Tunçtürk, Murat; Şekeroğlu, Nazım; Gezici, Sevgi

doi:10.5530/ijper.52.4s.83

Cited by 21 publications

(23 citation statements)

References 2 publications

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“…More recently, the researchers have mainly focused on examining the use of plant-derived natural products with less or no side effects for prevention and treatment in the cancer cases, since an increase in the incidences of drug resistance and side effects of drugs used for cancer therapy. A recent increase in the popularity of plant-derived natural products has increased interest in their essential oils as a potential herbal therapy (Cragg and Newman, 2005;Jinukuti and Giri, 2015;Manoharachary and Nagaraju, 2016;Belkhodja et al, 2017;Karik et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Original article Promising anticancer activity of lavender (Lavandulaangustifolia Mill.) essential oil through induction of both apoptosis and necrosis

Gezici¹

2018

Ann. Phytomed

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In the current study, potential anticancer and antiproliferative activity of EOs from lavender (Lavandula angustifolia Mill.) were determined against A549, H1299, C6 cancer cells and nontumorous HUVEC cells through induction of both apoptosis and necrosis. Furthermore, the differentiations of the cancer prevention activities of the EOs distilled from first and second year's harvest of the lavender growing under traditional system and plastic mulch were investigated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), trypan blue, neutral red uptake assays as well as lactate dehydrogenase (LDH) assay. The EOs exhibited remarkable anticancer and antiproliferative activity against all treated cancer cells, in a dose and time dependent manner. They exerted significantly decreases the cell growth in cancer cells, and also observed higher toxicity towards C6 glioma cells than the A549 and H1299 lung cells. In case of growing conditions of the EOs, higher anticancer and antiproliferative activity were observed under growing plastic mulch as compared to that of traditional system. Furthermore, first year's harvest of the lavender growing under plastic mulch seem to be possessed stronger cytotoxic effect than that of the second year's harvest. Besides, the lysosomal and LDH activity of the EOs were found to be highly in correlation with anticancer activity, and seem to be decreased obviously depending the year. It may be concluded that data obtained from the presented research demonstrates lavender EOs could have possible usage for cancer treatment as an alternative anticancer agent.

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Section: Discussionmentioning

confidence: 99%

Original article Promising anticancer activity of lavender (Lavandulaangustifolia Mill.) essential oil through induction of both apoptosis and necrosis

Gezici¹

2018

Ann. Phytomed

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“…Karik et al [ 24 ] reported the EO composition of S. officinalis collected in Turkey. The most abundant oxygenated monoterpene was β-thujone (34.59%), followed by α-thujone (12.60%) and camphor (10.09%).…”

Section: Resultsmentioning

confidence: 99%

Salvia officinalis L. from Italy: A Comparative Chemical and Biological Study of Its Essential Oil in the Mediterranean Context

et al. 2020

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Salvia officinalis L. (sage) is one of the most appreciated plants for its plethora of biologically active compounds. The objective of our research was a comparative study, in the Mediterranean context, of chemical composition, anticholinesterases, and antioxidant properties of essential oils (EOs) from sage collected in three areas (S1–S3) of Southern Italy. EOs were extracted by hydrodistillation and analyzed by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory properties were investigated by employing Ellman’s method. Four in vitro assays, namely, 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), ferric-reducing ability power (FRAP), and β-carotene bleaching tests, were used to study the antioxidant effects. Camphor (16.16–18.92%), 1,8-cineole (8.80–9.86%), β-pinene (3.08–9.14%), camphene (6.27–8.08%), and α-thujone (1.17–9.26%) are identified as the most abundant constituents. However, the content of these constituents varied depending on environmental factors and pedoclimatic conditions. Principal component analysis (PCA) was performed. Based on Relative Antioxidant Capacity Index (RACI), S2 essential oil exhibited the highest radical potential with an IC50 value of 20.64 μg/mL in ABTS test and presented the highest protection of lipid peroxidation with IC50 values of 38.06 and 46.32 μg/mL after 30 and 60 min of incubation, respectively. The most promising inhibitory activity against BChE was found for S3 sample (IC50 of 33.13 μg/mL).

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“…The 4 major component were eucalyptol (1,8-cineole) (27.08%), thujone (20.52%), camphor (16.99%), beta-pinene (4.07%). Other authors have reported sage essential oil with a comparable composition although there are some differences regarding the quantity of the individual compounds (Kırıcı et al, 1996;Delamare et al, 2007;Said-Al Ahl et al, 2015;Craft et al, 2017;Khedler et al, 2017;Çelik et al, 2018;Karik et al, 2018). The rosemary essential oil isolated was mainly composed of five compounds: eucalyptol (26.36%), camphor (29.17%), borneol (7.34%), alpha pinene (6.72%) camphene (4.95%) in this study.…”

Section: Discussionmentioning

confidence: 99%

Effect of Rosemary (Rosmarinus officinalis) and Sage (Salvia officinalis) Essential Oils on Disease Resistance against Aeromonas sobria in Goldfish (Carassius auratus)

Metin

Didinen

Kara

et al. 2020

Israeli Journal of Aquaculture - Bamidgeh

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In this study, the chemical composition and the antibacterial properties against Aeromonas sobria of the essential oils of rosemary and sage in gold fish were evaluated in vitro and in vivo for the first time. The major constituents were eucalyptol (26.36 %) and camphor (29.17 %) for rosemary essential oil and eucalyptol (27.08 %), thujone (20.52 %) and camphor (16.99 %) for sage oil. In vitro antibacterial effects of essential oils against A. sobria were detected by agar diffusion assay. The in vitro antibacterial effect of rosemary (20±2.82 mm) and sage (18.5±2.12 mm) essential oils (1000 µl ml-1) were determined to be strong against A. sobria (p˂0.05). The effects of the essential oils on the disease resistance of goldfish were also investigated. Fish (5±0.15 g) were fed with different concentrations (0, 1.0 and 3.0 ml kg-1) of each essential oil for 45 days. After feeding, the fish were challenged with A. sobria. Dietary administration of sage essential oil (1.0 and 3.0 ml kg-1) and rosemary oil (3 ml kg-1) resulted in a significant reduction in mortality due to A. sobria compared to control fish. Our results suggest that these plant oils could provide an alternative for A. sobria infection control in aquaculture. preventive measures are not taken, the disease is easily transmitted to other fish. Motile aeromonad septicaemia (MAS), is probably the most common bacterial disease in freshwater aquarium fish (Lewbart, 2001; Jagoda et al., 2014). Among the motile aeromonads, Aeromonas hydrophila, A. sobria and A. caviae are most commonly associated with fish. A. hydrophila has gained much attention as the most common fish pathogenic motile Aeromonas species, but other Aeromonas species may also play an essential role in infection (Beaz-Hidalgo and Figueras, 2012). The goldfish, Carrassius auratus has high susceptibility to Motile aeromonads (Citarasu et al., 2011). It is often an opportunistic infection, characterized by non-specific signs such as fin rot, ulceration, haemorrhages, exophthalmia and dropsy (Beaz-Hidalgo and Figueras, 2012). Antibiotics are commonly used for the treatment of fish infections in aquaculture. However, they cause significant problems including resistance development in bacteria, residue in fish tissue, suppression of immune system and damage of beneficial microbial flora (Defoirdt et al., 2007; Sapkota et al., 2008). For these reasons, alternative products have become more important for the control of fish diseases (Sivaram et al., 2004). The use of natural substances obtained from plants to control of fish diseases in aquaculture has increased (

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Essential Oil Composition of Some Sage (Salvia spp.) Species Cultivated in İzmir (Turkey) Ecological Conditions

Cited by 21 publications

References 2 publications

Original article Promising anticancer activity of lavender (Lavandulaangustifolia Mill.) essential oil through induction of both apoptosis and necrosis

Original article Promising anticancer activity of lavender (Lavandulaangustifolia Mill.) essential oil through induction of both apoptosis and necrosis

Salvia officinalis L. from Italy: A Comparative Chemical and Biological Study of Its Essential Oil in the Mediterranean Context

Effect of Rosemary (Rosmarinus officinalis) and Sage (Salvia officinalis) Essential Oils on Disease Resistance against Aeromonas sobria in Goldfish (Carassius auratus)

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