Erythema Multiforme Associated With Bupropion Use

Paroxetine and bupropion have no in vitro effects on lynphocyte proliferation and viability

“…These data suggest that the immunological effects of SSRIs are more favorable in subjects who had jeopardized immune responses concomitantly with psychiatric symptoms. Furthermore, inpatients usually suffer from more serious depressive symptoms than outpatients and thus are more likely to offer a better immunological response, under appropriate treatment, than outpatients (Carrillo-Jimenez et al, 2001). Similarly, severe depressive episodes, unlike those of moderate degrees, present a better response to the antidepressant treatment.…”

“…Except for some controversial discussion about the role of bupropion in the pathogenesis of medical conditions with immunological features (e.g. erythema multiform; Carrillo-Jimenez et al, 2001;Drago and Rebora, 2002), no investigations have been made to elucidate the immunological effects of bupropion in healthy individuals.…”

Bupropion Hydrochloride Induced Serum Sickness-Like Reaction

“…Serious adverse effects are rare and include seizures and hypersensitivity reactions. The latter can manifest with a variety of eruptions and as a semi-delayed (type III) reaction (4)(5)(6)(7)(8). Bupropion SR is contraindicated in patients with a current seizure disorder or history of seizures.…”

Selective serotonin-reuptake inhibitor and norepinephrine dopamine reuptake inhibitor antidepressants do not affect natural killer cell activity in vitro

“…Except for some controversial discussion about the role of bupropion in the pathogenesis of medical conditions with immunological features (e.g. erythema multiform) 11,12 , no investigations have been made to elucidate the immunological effects of bupropion in healthy individuals.…”