Paroxetine and bupropion have no in vitro effects on lynphocyte proliferation and viability

Abstract

Palavras-chaves

Selective serotonin-reuptake inhibitor and norepinephrine dopamine reuptake inhibitor antidepressants do not affect natural killer cell activity in vitro

“…There is also a greater probability of finding changes in lymphocyte 5HT transporters in patients with severe depression, melancholy and associated clinical co morbidities 1,2 . Furthermore, another study reported for the fist time that bubropion has no effect on lymphocyte proliferation 15 and, in the present study, cells pre-treated with bupropion maintained NK activity. Previous studies observed a tendency for improvement of the immune response with the administration of other double action antidepressants, with at least some serotonin action (mirtazapin) 9 .…”

“…In order to contribute to answer this question we decided to evaluate separately the effect in the IS of a drug with only serotonergic activity (paroxetine) and a drug with only noradrenergic/dopaminergic activity (bupropion) 13 . As we had the results regarding the activity of both drugs on lymphocyte proliferation 15 we decided to examine their citotoxicity and NKA action.…”

Assessment of potential in vitro genotoxic and cytotoxic effects of bupropion hydrochloride (wellbutrin) in human peripheral lymphocytes and human cortical neuron

“…In a similar study conducted by Ronchetti et al . (2007)[27] in bupropion and paroxetin, no significant differences in cell viability were found. The major objective of our study was to find whether WB is capable of producing genotoxic or cytotoxic effects in human peripheral lymphocytes.…”