Eryngium foetidum Suppresses Inflammatory Mediators Produced by Macrophages

Mekhora, Chusana; Muangnoi, Chawanphat; Chingsuwanrote, Pimjai; Dawilai, Suwitcha; Svasti, Saovaros; Chasri, Kaimuk; Tuntipopipat, Siriporn

doi:10.7314/apjcp.2012.13.2.653

Cited by 37 publications

(25 citation statements)

References 96 publications

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“…Activated macrophages increase their expression of iNOS and subsequently generate excess NO mainly after activation of NF-kB and MAPK signaling pathways . The excess NO helps to further the pathological complications associated with chronic inflammation (Bosca et al, 2005;Mekhora et al, 2012). In the study here, pretreatment with extract elicited significant inhibition of formaldehyde-induced paw edema from Days 2-5 post-injection.…”

Section: Discussionmentioning

confidence: 57%

Acacia ferrugineainhibits inflammation by regulating inflammatory iNOS and COX-2

Sakthivel

Guruvayoorappan

2015

Journal of Immunotoxicology

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Inflammation is a local defensive reaction of a host to cellular injury or infection. Prolonged inflammation can contribute to pathogenesis of many disorders. Identification of naturally occurring phytoconstituents that can suppress inflammatory mediators can lead to the discovery of anti-inflammatory therapeutics. Acacia ferruginea is used traditionally to treat numerous ailments including hemorrhage, irritable bowel syndrome and leprosy. The present study evaluated the anti-inflammatory activity of A. ferruginea extract against acute (carrageenan) and chronic (formaldehyde) inflammation in Balb/c mice. Pre-treatment with A. ferruginea extract (10 mg/kg BW) for 5 consecutive days via intraperitonial (IP) administration significantly inhibited subsequent induction of paw edema in both models; the effects were comparable to that of the standard drug indomethacin. The results also showed the A. ferruginea extract significantly inhibited nitric oxide (NO) synthesis and iNOS expression (as measured in serum), diminished inflammation in -and neutrophil infiltration to -the paw tissues and led to a reduction in the number of COX-2 + immunoreative cells (as evidenced by histologic and immunohistochemical analyses) in the paws relative to those in paws of mice that received the irritants only. Further, in vitro studies showed the extract could significantly scavenge free radicals generated as in DPPH and NO radical generating assays. Taken together, the results showed that A. ferruginea extract imparted potent anti-oxidant and -inflammatory effects, in part by maintaining oxidative homeostasis, inhibiting NO synthesis and suppressing iNOS and COX-2 expression and so could potentially be exploited as a potential plant-based medication against inflammatory disorders.

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Section: Discussionmentioning

confidence: 57%

Acacia ferrugineainhibits inflammation by regulating inflammatory iNOS and COX-2

Sakthivel

Guruvayoorappan

2015

Journal of Immunotoxicology

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“…The antioxidant activity of EF is supported by the study of Chanwitheesuk and coworkers (Chanwitheesuk et al, 2005) who have reported that the contents (mg%) of antioxidant compounds using a β-carotene bleaching method in dried EF were vitamin C (11.4±0.007), vitamin E (0.0069±0.0007), total carotenes (1.92±0.03), total xanthophylls (1.60±0.05), tannins (17.7±0.08), total phenolics (98.4±0.08), and antioxidant index was 5.65±0.46. A recent study provides supportive data on antioxidant and anti-inflammatory properties of EF leaves in LPS-induced murine macrophage cell lines (Mekhora et al, 2012). The same study also analyzed and identified bioactive components in the EF extract which found to have lutein, β-carotene, caffeic acid, chlorogenic acid and kaempferol.…”

Section: Discussionmentioning

confidence: 72%

“…Stigmasterol, a predominate phytosterol from the organic extract of the leaf, possesses topical anti-inflammatory activity against acute and chronic inflammation in animal model (Garcia et al, 1999). Recently, an ethanol extract from E. foetidum leaf showed suppression of LPSinduced pro-inflammatory mediator gene expression in RAW 264.7 murine macrophage (Mekhora et al, 2012). Another previous study showed that oral consumption of E. foetidum leaf decoction by rat inhibited carrageenaninduced paw edema and 12-o-tetradecanolyphorbol acetate-induced ear edema (Saenz et al, 1997).…”

mentioning

confidence: 99%

Anticlastogenic Effect of Eryngium foetidum L. Assessed by Erythrocyte Micronucleus Assay

Promkum¹,

Butryee²,

Tuntipopipat³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…The presence of chlorogenic acid was previously reported in the leaves and flowers of E. bourgatii [6], leaves of E. foetidum L. [3] and leaves and roots of E. planum L. [21]. The content of chlorogenic acid in the roots of E. palmatum (1.6±0.0 mg g -1 ) was higher than the previously reported content of chlorogenic acid in the roots of E. planum (0.19±0.00 mg g -1 ) [21].…”

Section: Composition Of Methanol and Chloroform Extractsmentioning

confidence: 94%

Composition, antimicrobial and antioxidant activity of the extracts of Eryngium palmatum Pančić and Vis. (Apiaceae)

et al. 2013

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The chemical composition, antimicrobial and antioxidant activity of Eryngium palmatum, an endemic plant species from the Balkan Peninsula, were investigated. The flavonoids apigenin (9.5±0.3 mg g−1) and apigenin 7-O-glucoside (2.4±0.1 mg g−1) were determined in a methanol extract of aerial parts using HPLC analysis. The methanol extract of roots contained catechin (5.0±0.1 mg g−1), epicatechin (2.9±0.1 mg g−1), chlorogenic acid (1.6±0.0 mg g−1), gallic acid (0.9±0.0 mg g−1) and rosmarinic acid (0.9±0.2 mg g−1). GC-FID and GCMS analysis of a chloroform extract of aerial parts showed that the main volatile constituents were falcarinol, linoleic acid, hexadecanoic acid and methyl linoleate (comprising 32.6%; 24.4%; 19.9; 13.2% of the volatile fraction, respectively), while octanoic acid, tetradecanol and dodecanol dominated in the chloroform extract of the roots (34.9%; 25.8%; 22.2% of the volatile fraction, respectively). Investigation of antimicrobial activity by broth microdilution showed that the methanol and chloroform extracts of aerial parts and roots exerted a significant effect (MIC 3.5–15.6 μg mL−1) against tested Gram-positive and Gram-negative bacteria. The methanol extracts of aerial parts or roots exerted moderate ferric reducing antioxidant power, DPPH radical scavenging activity and hydroxyl radical scavenging activity.

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Eryngium foetidum Suppresses Inflammatory Mediators Produced by Macrophages

Cited by 37 publications

References 96 publications

Acacia ferrugineainhibits inflammation by regulating inflammatory iNOS and COX-2

Acacia ferrugineainhibits inflammation by regulating inflammatory iNOS and COX-2

Anticlastogenic Effect of Eryngium foetidum L. Assessed by Erythrocyte Micronucleus Assay

Composition, antimicrobial and antioxidant activity of the extracts of Eryngium palmatum Pančić and Vis. (Apiaceae)

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