Eradication of <i>Helicobacter pylori</i> for the Prevention of Peptic Ulcer Rebleeding

Gisbert, Javier P.; Calvet, Xavier; Feu, Faust; Bory, Felipe; Cosme, Ángel; Almela, Pedro; Santolaria, Santos; Aznarez, Rosario; Castro, Manuel; Fernández, Nuria; García-Grávalos, R.; Cañete, Núria; Benages, A; Montoro, Miguel; Borda, Fernando; Pérez-Aísa, Ángeles; Piqué, J.M.

doi:10.1111/j.1523-5378.2007.00490.x

Cited by 32 publications

(21 citation statements)

References 57 publications

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“…One study found that as long as antibiotic eradication or Hp infection suppression is achieved, bleeding can be reduced [94]. Subsequent studies also confirmed that Hp eradication improves healing and decreases rebleeding [95–97]. …”

Section: Resultsmentioning

confidence: 99%

Diagnosis, Treatment, and Outcome in Patients with Bleeding Peptic Ulcers andHelicobacter pyloriInfections

Huang

Lee

2014

BioMed Research International

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Upper gastrointestinal (UGI) bleeding is the most frequently encountered complication of peptic ulcer disease. Helicobacter pylori (Hp) infection and nonsteroidal anti-inflammatory drug (NSAID) administration are two independent risk factors for UGI bleeding. Therefore, testing for and diagnosing Hp infection are essential for every patient with UGI hemorrhage. The presence of the infection is usually underestimated in cases of bleeding peptic ulcers. A rapid urease test (RUT), with or without histology, is usually the first test performed during endoscopy. If the initial diagnostic test is negative, a delayed 13C-urea breath test (UBT) or serology should be performed. Once an infection is diagnosed, antibiotic treatment is advocated. Sufficient evidence supports the concept that Hp infection eradication can heal the ulcer and reduce the likelihood of rebleeding. With increased awareness of the effects of Hp infection, the etiologies of bleeding peptic ulcers have shifted to NSAID use, old age, and disease comorbidity.

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Section: Resultsmentioning

confidence: 99%

Diagnosis, Treatment, and Outcome in Patients with Bleeding Peptic Ulcers andHelicobacter pyloriInfections

Huang

Lee

2014

BioMed Research International

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“…A combination of testing strategies in the hospital or a test-retest strategy where testing with invasive or noninvasive testing in the hospital is followed by postdischarge UBT retesting if initial tests are negative can yield optimal screening in this subgroup of patients [9,49]. An alternative strategy could be to use a one-time serological test since its sensitivity is not being influenced by recent treatment with PPI or the presence of blood in the antrum [8].…”

Section: Discussionmentioning

confidence: 95%

Non-invasive Testing for Helicobacter pylori in Patients Hospitalized with Peptic Ulcer Hemorrhage: A Cost-Effectiveness Analysis

Atreja

Sanaka

et al. 2009

Dig Dis Sci

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“…Diagnosis and successful H. pylori eradication have been shown to prevent recurrent PUB [1, 2]. Recently, the importance of early diagnosis and eradication of H. pylori during admission period of patients with PUB has been further emphasized because the rate of recurrent PUB has been reduced with such strategy [3].…”

Section: Introductionmentioning

confidence: 99%

Early Diagnosis of Helicobacter pylori Infection in Vietnamese Patients with Acute Peptic Ulcer Bleeding: A Prospective Study

Quach

Luu

Hiyama

et al. 2017

Gastroenterology Research and Practice

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Aims. To investigate H. pylori infection rate and evaluate a combined set of tests for H. pylori diagnosis in Vietnamese patients with acute peptic ulcer bleeding (PUD). Methods. Consecutive patients with acute PUB were enrolled prospectively. Rapid urease test (RUT) with 3 biopsies was carried out randomly. Patients without RUT or with negative RUT received urea breath test (UBT) and serological and urinary H. pylori antibody tests. H. pylori was considered positive if RUT or any noninvasive test was positive. Patients were divided into group A (RUT plus noninvasive tests) and group B (only noninvasive tests). Results. The overall H. pylori infection rate was 94.2% (161/171). Groups A and B had no differences in demographic characteristics, bleeding severity, endoscopic findings, and proton pump inhibitor use. H. pylori-positive rate in group A was significantly higher than that in group B (98.2% versus 86.7%, p = 0.004). The positive rate of RUT was similar at each biopsy site but significantly increased if RUT results from 2 or 3 sites were combined (p < 0.05). Conclusions. H. pylori infection rate in Vietnamese patients with acute PUB is high. RUT is an excellent test if at least 2 biopsies are taken.

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Eradication of Helicobacter pylori for the Prevention of Peptic Ulcer Rebleeding

Abstract: Peptic ulcer rebleeding does not occur in patients with complicated ulcers after H. pylori eradication. Maintenance anti-ulcer (antisecretory) therapy is not necessary if eradication is achieved.

Cited by 32 publications

References 57 publications

Diagnosis, Treatment, and Outcome in Patients with Bleeding Peptic Ulcers andHelicobacter pyloriInfections

Diagnosis, Treatment, and Outcome in Patients with Bleeding Peptic Ulcers andHelicobacter pyloriInfections

Non-invasive Testing for Helicobacter pylori in Patients Hospitalized with Peptic Ulcer Hemorrhage: A Cost-Effectiveness Analysis

Early Diagnosis of Helicobacter pylori Infection in Vietnamese Patients with Acute Peptic Ulcer Bleeding: A Prospective Study

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