Early Diagnosis of<i> Helicobacter pylori</i> Infection in Vietnamese Patients with Acute Peptic Ulcer Bleeding: A Prospective Study

Quach, Duc Trong; Luu, Mai; Hiyama, Toru; To, Thuy-HuongThi; Bui, Quy Nhuan; Tran, Tuan Anh; Tran, Binh Duy; Vo, Minh-Cong Hong; Tanaka, Shinji; Uemura, Naomi

doi:10.1155/2017/3845067

Cited by 7 publications

(5 citation statements)

References 20 publications

(34 reference statements)

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“…Concerning first-choice diagnostic tests for H. pylori, the American College of Gastroenterology recommended biopsy-based tests. Among these, rapid urease test is the most popular test in clinical practice but has high variable number of false-negative results according to a meta-analysis [42]. False positive results can occur if other urease containing organisms are present in sufficient quantity.…”

mentioning

confidence: 99%

Helicobacter Pylori Infection in Egyptian Patients With Dyspepsia: Diagnostic, Demographic, Endoscopic and Clinical Characteristics.

Diab¹,

Shenawy²,

Shemis³

et al. 2018

IJAR

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Helicobacter pylori, PCR, rapid urease test, stool antigen. was revealed in 27(45%) and 10 (16.7%) had peptic ulcer disease (PUD). Conclusions: H. pylori infection rate in Egyptian patients with dyspepsia was high and gastritis was the most revealed finding upon endoscopy. No risk factors were associated with H. pylori infection among the studied adult patients. Combined rapid urease and stool antigen tests can be relied upon for detecting H. pylori infection.

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confidence: 99%

Helicobacter Pylori Infection in Egyptian Patients With Dyspepsia: Diagnostic, Demographic, Endoscopic and Clinical Characteristics.

Diab¹,

Shenawy²,

Shemis³

et al. 2018

IJAR

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“…Another meta-study showed that repeating diagnostic tests for H. pylori at ≥4 weeks after stabilizing gastrointestinal bleeding detected significantly more patients with H. pylori infections ( 35 ). A local study of 171 patients presenting with peptic ulcer bleeding that used multiple sequential H. pylori tests reported that the rate of H. pylori infection was 94% ( 36 ).…”

Section: Resultsmentioning

confidence: 99%

Vietnam Association of Gastroenterology (VNAGE) consensus on the management of Helicobacter pylori infection

et al. 2023

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Helicobacter pylori (H. pylori) infection is prevalent and has a rapidly increasing antibiotic resistance rate in Vietnam. Reinfection is quite common, and gastric carcinoma remains one of the most common malignancies, which is not uncommon to develop after successful eradication. The purpose of this consensus is to provide updated recommendations on the management of H. pylori infection in the country. The consensus panel consisted of 32 experts from 14 major universities and institutions in Vietnam who were invited to review the evidence and develop the statements using the Delphi method. The process followed the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system. The consensus level was defined as ≥80% for agreement on the proposed statements. Due to the limited availability of high-quality local evidence, this consensus was also based on high-quality evidence from international studies, especially those conducted in other populations in the Asia–Pacific region. The panel finally reached a consensus on 27 statements after two voting rounds, which consisted of four sections (1) indications for testing and selection of diagnostic tests (2), treatment regimens, (3) post-treatment confirmation of H. pylori status, and (4) reinfection prevention methods and follow-up after eradication. Important issues that require further evidence include studies on third-line regimens, strategies to prevent H. pylori reinfection, and post-eradication follow-up for precancerous gastric lesions. We hope this consensus will help guide the current clinical practice in Vietnam and promote multicenter studies in the country and international collaborations.

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“…However, increasing the number of biopsy samples can increase the sensitivity of this test. 10,21 Castro Fernández M et al, 22 reported that among nonbleeding duodenal ulcer patients RUT sensitivity was 93%, whereas, among patients with bleeding, it is 83%. The difference was reported to be statistically significant.…”

Section: Discussionmentioning

confidence: 99%

“…The sensitivity of RUT in the presence of blood was 15%, while in the absence of blood it was 75%. However, increasing the number of biopsy samples can increase the sensitivity of this test 10,21 …”

Section: Discussionmentioning

confidence: 99%

Upper gastrointestinal bleeding: Diagnosis of Helicobacter pylori infection—Descriptive study

Azadbakht,

Azadbakht

2024

Health Science Reports

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Background and AimThe presence of blood in the stomach has been thought to affect the performance of diagnostic tests used in detecting Helicobacter pylori (H. pylori) in the stomach. This study evaluates the effect of upper gastrointestinal bleeding on the efficacy of a rapid urease test (RUT) and compares the results with the pathologic method.MethodsIn this descriptive study, 100 patients presented with upper gastrointestinal bleeding, confirmed from endoscopy, referred to Shahid Rahimi Hospital in Khorramabad were enrolled. Antral biopsy was performed in all the patients and the samples were extracted for histopathology and RUT. A questionnaire was used to collect rapid urease test outcomes and associated parameters (antibiotic, bismuth, and proton pump inhibitors), histology and demographic data. Histopathology was used as the gold standard for diagnosis of H. pylori.ResultsOf the 52 patients who were reported positive for H. pylori in pathology, 36 had RUT‐positive H. pylori, sensitivity 69.2%, and of 48 patients whose pathology was negative, 25 had negative RUT, specificity 52.1%. Of 59 RUT, 36 had positive pathology, positive predictive value was 61% and from 41 with negative RUT, 25 had negative pathology, negative predictive value was 61%. The prevalence of H. pylori infection was significantly associated with the age of 50 years and above, p = 0.042, and previous history of bleeding, p = 0.019.ConclusionGastrointestinal bleeding can reduce the sensitivity of RUT. The negative results of these tests in acute upper gastrointestinal bleeding should therefore be interpreted carefully.

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Early Diagnosis of Helicobacter pylori Infection in Vietnamese Patients with Acute Peptic Ulcer Bleeding: A Prospective Study

Cited by 7 publications

References 20 publications

Helicobacter Pylori Infection in Egyptian Patients With Dyspepsia: Diagnostic, Demographic, Endoscopic and Clinical Characteristics.

Helicobacter Pylori Infection in Egyptian Patients With Dyspepsia: Diagnostic, Demographic, Endoscopic and Clinical Characteristics.

Vietnam Association of Gastroenterology (VNAGE) consensus on the management of Helicobacter pylori infection

Upper gastrointestinal bleeding: Diagnosis of Helicobacter pylori infection—Descriptive study

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