Non-invasive Testing for Helicobacter pylori in Patients Hospitalized with Peptic Ulcer Hemorrhage: A Cost-Effectiveness Analysis

Atreja, Ashish; Fu, Alex Z.; Sanaka, Madhusudan; Vargo, John J.

doi:10.1007/s10620-009-0865-6

Cited by 6 publications

(5 citation statements)

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“…Established uses of VOC measurements include the assessment of environmental contamination, flavor and fragrance industry, and counterterrorism. Examples of the analysis of exhaled VOCs within clinical practice include breathalyzer devices for ethanol detection, carbon 13 urea breath testing for Helicobacter pylori , exhaled nitric oxide in asthma, and hydrogen-methane testing for small-bowel bacteria overgrowth . Breath testing has the potential to address a central diagnostic dilemma in cancer.…”

Section: Introductionmentioning

confidence: 99%

“…Examples of the analysis of exhaled VOCs within clinical practice include breathalyzer devices for ethanol detection, carbon 13 urea breath testing for Helicobacter pylori, exhaled nitric oxide in asthma, and hydrogen-methane testing for smallbowel bacteria overgrowth. [2][3][4][5] Breath testing has the potential to address a central diagnostic dilemma in cancer. The presence of red flag symptoms, which are often the initiating factor for investigation of underlying malignancy, typically occur late in the disease process and are associated with poor prognosis.…”

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confidence: 99%

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Accuracy and Methodologic Challenges of Volatile Organic Compound–Based Exhaled Breath Tests for Cancer Diagnosis

2019

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

Accuracy and Methodologic Challenges of Volatile Organic Compound–Based Exhaled Breath Tests for Cancer Diagnosis

2019

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“…Measurements of VOCs have been used to assess counterterrorism, environmental contamination, and the flavor and fragrance industry. Analysis of exhaled VOCs has been in used in clinical practice in the forms of carbon 13 urea breath testing for Helicobacter pylori, exhaled nitric oxide (NO) in asthma, hydrogen-methane testing for small-bowel bacteria overgrowth and ethanol detection [14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Exhaled Breath Biopsy: A New Cancer Detection Paradigm

Abderrahman

2019

Future Oncol.

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“…However, there has been a paucity of external validation studies where researchers have validated the findings in an independent population [17]. Currently, VOCs that are in routine clinical applications include exhaled nitric oxide in asthma [13,18,19], C urea breath testing for H. pylori [20] and hydrogen/ methane testing for small bowel intestinal overgrowth [21].…”

Section: Introductionmentioning

confidence: 99%

Optimisation of sampling parameters for standardised exhaled breath sampling

2017

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The lack of standardization of breath sampling is a major contributing factor to the poor repeatability of results and hence represents a barrier to the adoption of breath tests in clinical practice. On-line and bag breath sampling have advantages but do not suit multicentre clinical studies whereas storage and robust transport are essential for the conduct of wide-scale studies. Several devices have been developed to control sampling parameters and to concentrate volatile organic compounds (VOCs) onto thermal desorption (TD) tubes and subsequently transport those tubes for laboratory analysis. We conducted three experiments to investigate (i) the fraction of breath sampled (whole vs. lower expiratory exhaled breath); (ii) breath sample volume (125, 250, 500 and 1000ml) and (iii) breath sample flow rate (400, 200, 100 and 50 ml/min). The target VOCs were acetone and potential volatile biomarkers for oesophago-gastric cancer belonging to the aldehyde, fatty acids and phenol chemical classes. We also examined the collection execution time and the impact of environmental contamination. The experiments showed that the use of exhaled breath-sampling devices requires the selection of optimum sampling parameters. The increase in sample volume has improved the levels of VOCs detected. However, the influence of the fraction of exhaled breath and the flow rate depends on the target VOCs measured. The concentration of potential volatile biomarkers for oesophago-gastric cancer was not significantly different between the whole and lower airway exhaled breath. While the recovery of phenols and acetone from TD tubes was lower when breath sampling was performed at a higher flow rate, other VOCs were not affected. A dedicated 'clean air supply' overcomes the contamination from ambient air, but the breath collection device itself can be a source of contaminants. In clinical studies using VOCs to diagnose gastro-oesophageal cancer, the optimum parameters are 500mls sample volume of whole breath with a flow rate of 200ml/min. .

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Non-invasive Testing for Helicobacter pylori in Patients Hospitalized with Peptic Ulcer Hemorrhage: A Cost-Effectiveness Analysis

Abstract: Post-endoscopy UBT is cost effective in PPI-naïve patients presenting with PUH. This strategy, once prospectively validated, can prove to be a preferred approach in institutions where compliance with invasive testing is suboptimal.

Cited by 6 publications

References 39 publications

Accuracy and Methodologic Challenges of Volatile Organic Compound–Based Exhaled Breath Tests for Cancer Diagnosis

Accuracy and Methodologic Challenges of Volatile Organic Compound–Based Exhaled Breath Tests for Cancer Diagnosis

Exhaled Breath Biopsy: A New Cancer Detection Paradigm

Optimisation of sampling parameters for standardised exhaled breath sampling

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