Epidemiology and treatment of angiolymphoid hyperplasia with eosinophilia (ALHE): A systematic review

Eosinophilia

“…Excision and laser therapy seem to be the most often used treatment modalities, often undertaken for cosmetic reasons. 31 Peripheral eosinophilia is variable and IgE elevation is not common.…”

Angiolymphoid hyperplasia with eosinophilia: report of nine cases

“…Angiolymphoid hyperplasia with eosinophilia can be asymptomatic, as was noted in 15.4% of reported cases. If symptomatic, the most commonly reported symptom by Adler was pruritus (36.8%), followed by bleeding (25.3%) as seen in one‐third of our patients . In most series, including ours, ALHE is typically characterized by single or multiple, dermal and/or subcutaneous, flesh‐ to plum‐colored papules or nodules, ranging in size from a few to several centimeters.…”

“…In most series, including ours, ALHE is typically characterized by single or multiple, dermal and/or subcutaneous, flesh‐ to plum‐colored papules or nodules, ranging in size from a few to several centimeters. They are frequently located on the head, which is involved in 81.8% of cases in previous reports . The most common locations are periauricular area (36.3%), face (28.2%), and scalp (17.3%) .…”

“…However, a male predominance is noted by the US Armed Forces Institute of Pathology in a series of 116 patients . More recently, a systematic review including 416 studies and representing 908 patients with ALHE demonstrated near sex parity . This difference may be explained by recruitment bias, varying number of patients, and/or geographic differences.…”

Angiolymphoid hyperplasia of external ear treated with intralesional radiofrequency ablation

“…Occurrence on exposed sites may lead to cosmetic disfigurement. Despite having multiple medical and surgical treatment options, the rate of recurrence is high 4. Intralesional RFA is one of the recent modalities being tried in this condition.…”