Angiolymphoid hyperplasia with eosinophilia: report of nine cases

Bahloul, E.; Amouri, M.; Boudawara, Ons; Mnif, H.; Boudawara, T.; Turki, H.

doi:10.1111/ijd.13800

Cited by 17 publications

(8 citation statements)

References 23 publications

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“…Many approaches have been used to treat ALHE, including surgical excision, 2 , 3 , 5 , 8–10 steroids, and other drugs, 11–16 as well as biological and physical therapy. 17–22 Surgery is the mainstay of ALHE treatment, although surgery is less successful for cases with poorly delineated multiple nodules.…”

Section: Discussionmentioning

confidence: 99%

“…Angiolymphoid hyperplasia with eosinophilia (ALHE), first described in 1969 by Wells and Whimster, 1 is a rare benign vascular disease. Despite its benign nature, ALHE presents a therapeutic dilemma, 2 as persistent or recurrent lesions with clear symptoms may require treatment. Various modalities such as surgical excision, corticosteroids, radiotherapy, laser therapy, and other therapies have been used to treat ALHE.…”

Section: Introductionmentioning

confidence: 99%

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Novel Application of³²P Brachytherapy: Treatment of Angiolymphoid Hyperplasia with Eosinophilia in the Right Auricle with 8-Year Follow-Up

Zhang

Wen

et al. 2018

Cancer Biotherapy and Radiopharmaceuticals

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Background: Angiolymphoid hyperplasia with eosinophilia (ALHE) is a distinctive benign vascular disease that can be challenging to treat due to inconsistent results for various treatment modalities such as surgical excision, corticosteroids, radiotherapy, laser therapy, and other therapies, so novel approaches are needed to improve treatment outcomes.Materials and Methods: ALHE on the right auricle of a 54-year-old Chinese woman underwent brachytherapy using 32P simple drug membranes for five times. The 32P brachytherapy involving simple drug membranes of brachytherapy began by diluting a 32P solution with 0.9% NaCl solution to produce a radioactivity of 69.2–74.7 MBq/mL(1.87–2.02 mCi/mL). The drug membranes were removed between 48 and 72h after application. There were intervals ranging from 65 to 72d between the membrane application periods, and the last treatment was in June 2010.Results: After the 32P brachytherapy, follow-up results over the course of 8 years were promising. The regional symptoms disappeared, the right preauricular swelling decreased, the subcutaneous nodules decreased in size, the exudate disappeared, and the skin appearance improved.Conclusions: This case indicated that 32P brachytherapy may represent a novel ALHE treatment method that produces a favorable long-term outcome.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Novel Application of³²P Brachytherapy: Treatment of Angiolymphoid Hyperplasia with Eosinophilia in the Right Auricle with 8-Year Follow-Up

Zhang

Wen

et al. 2018

Cancer Biotherapy and Radiopharmaceuticals

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“…ALHE occurs most often in young or middle-aged adults, and more frequently in women, giving rise to theories that estrogen sensitivity is a component of pathogenesis. More frequent than Kimura disease, of which it is the main differential diagnosis [2]. It may present as one or multiple erythematous, purple, angiomatous papules, nodules or plaques with a predilection for the head and neck region, especially the auricular area.…”

Section: Angio-lymphoid Hyperplasia With Eosinophilia (Alhe)mentioning

confidence: 99%

Erythematous nodules of the ear and the retro-auricular area in a Moroccan woman. What’s your diagnosis?

Kassel¹,

Shanshal²,

Alaoui³

et al. 2022

Our Dermatol Online

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“…Fewer than 1000 cases of ALHE and 300 cases of Kimura's disease has been reported so far. 1,2 In the olden days, both were thought to be two different presentations of the same disease. Although they share overlapping features, with distinctive clinical, epidemiological and histopathological features which were declared currently, both are considered as separate entities.…”

Section: Introductionmentioning

confidence: 99%

Dilemma in diagnosing a post-auricular mass-angiolymphoid hyperplasia with eosinophilia versus Kimura’s disease, an infrequent encounter

Shetty

Chandrashekar

Ganesan

et al. 2021

Int J Otorhinolaryngol Head Neck Surg

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<p class="abstract">Angiolymphoid hyperplasia with eosinophilia (ALHE) and Kimura’s disease are uncommon chronic benign lesions of the skin mainly involving the head and neck regions where ALHE involves vascular and lymphocytic proliferation and Kimura’s is of inflammatory type. Dermal involvement is more in ALHE but In Kimura’s disease the lymphnodes and subcutaneous tissues are involved more. ALHE is a rare vascular tumor and Kimura’s disease is a chronic inflammatory disease. Both not only have uncertainty in etiology and pathogenesis, but also there is therapeutic dilemma in management. In this article, we describe a case of ALHE which presented to our ENT outpatient department with swelling in the left postauricular region which appeared 1.5 years back and posed a riddle in coming to correct diagnosis. On examination, a single smooth spherical swelling in upper part of post-auricular region of size 3×3 cm with well-defined edges and normal skin. Blood investigations revealed elevated absolute eosinophil count. HRCT temporal bone showed a well-defined rounded hypo-dense lesion measuring 28×23 mm with no effect of adjacent bony erosion / calcifications/ cystic changes suggestive of benign etiology. FNAC showed scantly cellular and occasionally scattered fibroblasts, pinkish stromal collagen fragments with inflammatory cells in background of haemorrhage suggestive of soft tissue neoplasm.</p>

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Angiolymphoid hyperplasia with eosinophilia: report of nine cases

Abstract: Angiolymphoid hyperplasia with eosinophilia is a rare epithelioid vascular tumor with a challenging clinical and histological diagnosis. Despite its benign nature, ALHE causes a therapeutic dilemma.

Cited by 17 publications

References 23 publications

Novel Application of³²P Brachytherapy: Treatment of Angiolymphoid Hyperplasia with Eosinophilia in the Right Auricle with 8-Year Follow-Up

Novel Application of³²P Brachytherapy: Treatment of Angiolymphoid Hyperplasia with Eosinophilia in the Right Auricle with 8-Year Follow-Up

Erythematous nodules of the ear and the retro-auricular area in a Moroccan woman. What’s your diagnosis?

Dilemma in diagnosing a post-auricular mass-angiolymphoid hyperplasia with eosinophilia versus Kimura’s disease, an infrequent encounter

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Angiolymphoid hyperplasia with eosinophilia: report of nine cases

Abstract: Angiolymphoid hyperplasia with eosinophilia is a rare epithelioid vascular tumor with a challenging clinical and histological diagnosis. Despite its benign nature, ALHE causes a therapeutic dilemma.

Cited by 17 publications

References 23 publications

Novel Application of32P Brachytherapy: Treatment of Angiolymphoid Hyperplasia with Eosinophilia in the Right Auricle with 8-Year Follow-Up

Novel Application of32P Brachytherapy: Treatment of Angiolymphoid Hyperplasia with Eosinophilia in the Right Auricle with 8-Year Follow-Up

Erythematous nodules of the ear and the retro-auricular area in a Moroccan woman. What’s your diagnosis?

Dilemma in diagnosing a post-auricular mass-angiolymphoid hyperplasia with eosinophilia versus Kimura’s disease, an infrequent encounter

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Product

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Novel Application of³²P Brachytherapy: Treatment of Angiolymphoid Hyperplasia with Eosinophilia in the Right Auricle with 8-Year Follow-Up

Novel Application of³²P Brachytherapy: Treatment of Angiolymphoid Hyperplasia with Eosinophilia in the Right Auricle with 8-Year Follow-Up