Eosinophilia

Kovalszki, Anna; Weller, Peter F.

doi:10.1016/j.pop.2016.07.010

Cited by 122 publications

(93 citation statements)

References 33 publications

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“…Certainly, its application may contribute to a better understanding of processes associated with the immune response and inflammation involving eosinophils, as their LBs dynamically respond through activation of mediators like eicosanoids and the cytokine, TNF (Melo & Weller, ). They are associated with the incompletely unnderstood aetiology of eosinophilia‐based diseases, such as aspirin‐related asthma, acute myeloid leukaemia, Crohn's disease, cancer, immunodeficiency and others (Kovalszki & Weller, ).…”

Section: Discussionmentioning

confidence: 99%

Raman imaging highlights biochemical heterogeneity of human eosinophils versus human eosinophilic leukaemia cell line

et al. 2019

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Summary Eosinophils are acidophilic granulocytes that develop in the bone marrow. Although their population contributes only to approximately 1–6% of all leucocytes present in the human blood, they possess a wide range of specific functions. They play a key role in inflammation‐regulating processes, when their numbers can increased to above 5 × 109/l of peripheral blood. Their characteristic feature is the presence of granules containing eosinophil peroxidase (EPO), the release of which can trigger a cascade of events promoting oxidative stress, apoptosis or necrosis, leading finally to cell death. Raman spectroscopy is a powerful technique to detect EPO, which comprises a chromophore protoporphyrin IX. Another cell structure associated with inflammation processes are lipid bodies (lipid‐rich organelles), also well recognized and imaged using high resolution confocal Raman spectroscopy. In this work, eosinophils isolated from the blood of a human donor were analysed versus their model, EoL‐1 human eosinophilic leukaemia cell line, by Raman spectroscopic imaging. We showed that EPO was present only in primary cells and not found in the cell line. Eosinophils were activated using phorbol 12‐myristate 13‐acetate, which resulted in lipid bodies formation. An effect of cells stimulation was studied and compared for eosinophils and EoL‐1.

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Section: Discussionmentioning

confidence: 99%

Raman imaging highlights biochemical heterogeneity of human eosinophils versus human eosinophilic leukaemia cell line

et al. 2019

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“…[9][10][11][12][13][14][15] Moreover, there are some reports about the presence of eosinophilia in protozoan infections such as isosporiasis, sarcocystosis, and dientamoebiasis. [16][17][18] To the best of our knowledge, the level of eosinophils in different parasitic diseases less has been evaluated, particularly in Iran. Therefore, the aim of the present study was to evaluate and compare the percentage of eosinophils in different parasitic diseases at Baqiyatallah hospital, Tehran, Iran.…”

Section: Introductionmentioning

confidence: 99%

Eosinophils and Parasitic Infections

Rahimi¹,

Mohammadzade²,

Khanaliha³

2018

Int J Enteric Pathog

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Background: Eosinophils dysregulate immune responses associated with malignancies, allergic and parasitic diseases especially helminthic infections, though it is infrequently observed with protozoan diseases. Objective: The aim of the present study was to evaluate and compare the percentage of eosinophils in different parasitic diseases at Baqiyatallah Hospital, Tehran, Iran. Materials and Methods: One hundred and 72 samples were obtained from 74 and 98 patients with helminthic and protozoan diseases respectively and evaluated. Direct wet mount and formalin ether concentration were used for intestinal parasites identification. Scotch tape test and serological methods were utilized for diagnosis of Enterobius vermicularis and tissue parasites respectively. Eosinophils were counted and six or more percentages were considered as eosinophilia. Results: In general, in 34 out of 74 helminthic infections (45.9%) and 5 out of 98 protozoan infections (5.1%), an eosinophil level equal or more than 6% was observed. The rate of eosinophilia in helminthic infections were 13/18 (72.2%), 7/11 (63.6%), 3/10 (30%), 2/3 (66.7%), 1/9 (11.11%), 5/13 (38.5%), 3/4 (75%) in the patients with fasciolosis, strongyloidiasis, hymenolepiasis, hookworm infection, enterobiasis, echinococcosis, and trichostrongyliasis, respectively. Concerning the protozoan infections, 3/26(11.5%) and 2/20(10%) of the individuals suffering from giardiasis and blastocystosis showed an eosinophil level higher than normal range, respectively. Conclusion: As expected, helminthic infections especially fasciolosis and strongyloidiasis were the most important infections correlated with eosinophilia. According to available reports, eosinophilia higher than normal range in giardiasis and blastocystosis is not unexpected.

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“…The differential diagnosis of eosinophilia (defined as an absolute eosinophil count (AEC) > 500 cells/µL [3]) is broad and includes a wide range of conditions, from allergic to autoimmune disease (Table 1) [2,4,5]. The first step in the approach of eosinophilia is distinguishing between primary (where the main defect is affecting the regulation of eosinophils production) and secondary (or reactive) eosinophilia.…”

Section: Discussionmentioning

confidence: 99%

“…Some essential aspects include different signs and symptoms that are suggestive of endorgan compromise by eosinophilia (skin, pulmonary, cardiac, GI, skin, and neurologic), a complete medications and natural supplements list, past medical history including neoplastic conditions, allergic/atopic symptoms, travel and social history, and a complete physical examination to identify features suggestive of a specific disorder or etiology [5]. Medications are a frequent cause of eosinophilia, and the development of eosinophilia may not coincide with the introduction of the medications.…”

Section: Discussionmentioning

confidence: 99%

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A 37-Year-Old Female With Abdominal Pain and Diarrhea: A Case of Idiopathic Hypereosinophilic Syndrome

et al. 2017

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We report a case of a 37-year-old female who presented with diffuse abdominal pain associated with dysphagia, weight loss, and history of chronic non-bloody diarrhea. Labs showed severe eosinophilia and esophagogastroduodenoscopy (EGD) showed patchy erythema in antrum and body of the stomach. The pathological exam showed lymphoplasmacytic inflammation of lamina propria with increased eosinophil count and eosinophilic abscesses. The immunophenotypic analysis did not show evidence of clonality. There was no evidence of allergic reaction or infection. In view of the absence of causes to explain severe eosinophilia, the diagnosis of hypereosinophilic syndrome (HES) was made and she was started on steroids with improvement in her symptoms and eosinophils counts in subsequent evaluations.

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Eosinophilia

Cited by 122 publications

References 33 publications

Raman imaging highlights biochemical heterogeneity of human eosinophils versus human eosinophilic leukaemia cell line

Raman imaging highlights biochemical heterogeneity of human eosinophils versus human eosinophilic leukaemia cell line

Eosinophils and Parasitic Infections

A 37-Year-Old Female With Abdominal Pain and Diarrhea: A Case of Idiopathic Hypereosinophilic Syndrome

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