Epidemiology and Differential Diagnosis of Nasal Polyps

Chaaban, Mohamad R.; Walsh, Erika M.; Woodworth, Bradford A.

doi:10.2500/ajra.2013.27.3981

Cited by 130 publications

(109 citation statements)

References 103 publications

(148 reference statements)

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“…This was in accordance with the studies by Lathi et al [27], and Zafar et al [28] where second to fourth decade was most commonly affected. However, Chaaban et al [29] showed an increased incidence in older age group with a mean onset of 42.5 years. Nasal polyps had slight predilection for males in our study, (male:female ratio of 1.3:1).…”

Section: Resultsmentioning

confidence: 97%

Detection of Helicobacter pylori in Nasal Polyps

Bansal

Sharma

Agarwal

et al. 2016

Head and Neck Pathol

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To detect the presence of Helicobacter pylori in nasal polyps. A case-control study was conducted enrolling 35 patients with nasal polyps (cases) and patients undergoing septoplasty (controls). Fresh tissue samples were used for urea broth test and imprint cytology, while formalin fixed tissue sections were used for morphology, special stains and immunohistochemistry for H. pylori. Fresh stool samples from both groups were tested to correlate the gastrointestinal status. H. pylori was detected in 40.0 % (14/35) of cases and 8.5 % of controls (3/35) (p = 0.004) by immunohistochemistry. Amongst cases, eight were positive with urea broth test, six with imprint cytology (Giemsa stain), three with H & E, and nine with modified McMullen's stain. Hyperplasia of the lining epithelium and lymphoid aggregates were significantly noticed in nasal polyps positive for H. pylori. Stool antigen test was positive in subjects who were positive for H. pylori in the nasal mucosa. There appears to be an association between H. pylori and nasal polyps. Immunohistochemistry is more sensitive and specific method to detect H. pylori.H. pylori induced inflammatory tissue reaction pattern indicates a possible causal association. Further studies are needed to prove the causal relationship between H. pylori and nasal polyps.

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Section: Resultsmentioning

confidence: 97%

Detection of Helicobacter pylori in Nasal Polyps

Bansal

Sharma

Agarwal

et al. 2016

Head and Neck Pathol

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“…370 Staphylococcus aureus is a common organism in polypoid RS, and may modify these disease processes as a direct pathogen or via superantigen production. 903,925,1084,1093,1094 S. aureus colonization is more prevalent in AFRS vs other CRSwNP subtypes. 925 Vitamin D 3 levels are also decreased in CRSwNP and AFRS, with levels inversely correlating with bone erosion.…”

Section: Viiig Crswnp and Afrs: Differences In Pathophysiologymentioning

confidence: 99%

“…1077,1083 Dematiaceous fungi and Aspergillus are commonly identified, but fungi are diverse and vary based on geographical region. 1073,1075,1076,1081,1083,1084 Interestingly, correlation between fungal species in mucin and systemic fungal allergy was poor in 1 Australian study. 370 Clinically, AFRS tends to be a more severe form of CRSwNP.…”

Section: Viiig Crswnp and Afrs: Differences In Pathophysiologymentioning

confidence: 99%

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

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541

877

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Background:The body of knowledge regarding rhinosinusitis (RS) continues to expand, with rapid growth in number of publications, yet substantial variability in the quality of those presentations. In an effort to both consolidate and critically appraise this information, rhinologic experts from around the world have produced the International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR:RS). Methods:Evidence-based reviews with recommendations (EBRRs) were developed for scores of topics, using previously reported methodology. Where existing evidence was insufficient for an EBRR, an evidence-based review (EBR) was produced. The sections were then synthesized and the entire manuscript was then reviewed by all authors for consensus. Results:The resulting ICAR:RS document addresses multiple topics in RS, including acute RS (ARS), chronic RS (CRS) with and without nasal polyps (CRSwNP and CRSsNP), recurrent acute RS (RARS), acute exacerbation of CRS (AE-CRS), and pediatric RS. Conclusion:As a critical review of the RS literature, ICAR:RS provides a thorough review of pathophysiology and evidence-based recommendations for medical and surgical treatment. It also demonstrates the significant gaps in our understanding of the pathophysiology and optimal management of RS. Too o en the foundation upon which these recommendations are based is comprised of lowerlevel evidence. It is our hope that this summary of the evidence in RS will point out where additional research efforts may be directed. C 2016 ARS-AAOA, LLC. Key Words:rhinosinusitis; chronic rhinosinusitis; acute rhinosinusitis; recurrent acute rhinosinusitis; evidence-based medicine; systematic review; endoscopic sinus surgery List of Abbreviations Used

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“…1 The incidence of CRSwNP is approximately one-tenth of the incidence of CRSsNP. 2 The prevalence of CRSwNP is ϳ1%, whereas the prevalence of CRSsNP is less clear but estimated at approximately 10-fold higher.…”

Section: Hronic Rhinosinusitis (Crs) Is Characterized By Mucosal Inmentioning

confidence: 99%