How Often is Sinus Surgery Performed for Chronic Rhinosinusitis with versus without Nasal Polyps?

Ference, Elisabeth H.; Suh, Jeffrey D.; Tan, Bruce K.; Smith, Stephanie Shintani

doi:10.2500/ajra.2018.32.4495

Cited by 16 publications

(28 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The overall presentation of symptoms is likely a combination of the aforementioned factors. Better characterization of facial pain in both QOL and clinical contexts could be important in delineating CRS subtypes and guiding treatment decisions . Furthermore, early identification of patients with proportionally higher ear and facial dysfunction at baseline could predict decreased improvement in these symptoms after ESS, as well as increased opioid requirement in the postoperative setting.…”

Section: Discussionmentioning

confidence: 99%

Predictive value of SNOT‐22 on additional opiate prescriptions after endoscopic sinus surgery

Shen

Jafari

Bracken

et al. 2018

Int Forum Allergy Rhinol

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Predictive value of SNOT‐22 on additional opiate prescriptions after endoscopic sinus surgery

Shen

Jafari

Bracken

et al. 2018

Int Forum Allergy Rhinol

View full text Add to dashboard Cite

show abstract

“…Resource utilization and costs related to surgery were reported in seven studies (see study characteristics in Supplementary Table 16) 99,[102][103][104][105][106][107] . Six studies were conducted in the United States 99,[102][103][104][105]107 and one in the UK 106 , including Scotland and Wales. The UK study used data from the Chronic Rhinosinusitis Epidemiology Study (CRES) 106 .…”

Section: Resource Utilization and Costs Related To Surgerymentioning

confidence: 99%

“…The UK study used data from the Chronic Rhinosinusitis Epidemiology Study (CRES) 106 . Four studies were retrospective database analyses 99,103,104,107 , one was a retrospective cohort study 105 and two were crosssectional studies 102,106 .…”

Section: Resource Utilization and Costs Related To Surgerymentioning

confidence: 99%

“…One US study 102 reported the median charge for ESS procedures. Using the State Ambulatory Surgery Databases for the regions of Florida, Maryland and New York, Ference et al 102 found that ESS procedures were associated with a median total charge of $13,264 (Figure 8). In addition, pan-ESS was found to be a more expensive procedure compared to mini-ESS (median total charge of $17,272 vs. $11,213).…”

Section: Resource Utilization and Costs Related To Surgerymentioning

confidence: 99%

See 1 more Smart Citation

Systematic literature review of humanistic and economic burdens of chronic rhinosinusitis with nasal polyposis

Chen

Zhou

Emmanuel

et al. 2020

Current Medical Research and Opinion

View full text Add to dashboard Cite

Objectives: We conducted a systematic literature review (SLR) of randomized controlled trials and real-world evidence (RWE) studies to determine the humanistic (e.g. health-related/disease-specific quality of life [QOL]) and economic (e.g. direct and indirect costs) burdens of chronic rhinosinusitis with nasal polyposis (CRSwNP). Methods: The SLR adhered to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Embase, MEDLINE and Evidence-Based Medicine Reviews databases were searched using OVID. Relevant studies involving adult patients with CRSwNP published between 1 January 2008 and 16 February 2019 were included, with relevant conference abstracts from 1 January 2017, onward. Results: Sino-Nasal Outcomes Test (SNOT)-22 was the most frequently used disease-specific healthrelated QOL/patient-reported outcomes instrument for patients with CRSwNP. Baseline SNOT-22 scores ranged from 25 to 73 for surgical candidates and from 14 to 56 for medically managed patients with CRSwNP. Mean baseline EuroQol-5 Dimensions (EQ-5D) index for patients with CRSwNP ranged from 0.81 to 0.86, and mean baseline Short Form-6 Dimensions (SF-6D) ranged from 0.67 to 0.75. Three months (EQ-5D) and 5 years (SF-6D) post-endoscopic sinus surgery (ESS), rates increased from 0.81 to 0.89 and from 0.69 to 0.80, respectively. One year post-diagnosis, patients with CRSwNP had significantly more systemic prescriptions, underwent significantly more medical procedures, demonstrated greater health care resource utilization and had significantly greater mean health care costs compared with matched controls (all p < .001). Overall, for patients with initial ESS, CRSwNP was associated with higher disease-related expenditures compared with CRS without nasal polyposis (NP), even for patients who did not undergo revision surgery. Conclusions: This SLR identified substantial humanistic burden among surgery candidates. RWE shows that surgeries were used to treat relatively more severe CRSwNP patients as recommended by guidelines. Patient QOL is improved significantly after surgery; however, there is a lack of evidence on patients with revision surgery. Surgery is also associated with higher costs, and the presence of NP was a predictor of revision surgery. Patients with CRSwNP demonstrate greater health care resource utilization and costs compared to those with CRS without NP. Costs associated with different severity of CRSwNP and revision surgery need to be assessed further.

show abstract

“…Roughly, 30% of all sinus surgery is performed for CRSwNP. These surgeries are usually longer, more extensive, and more likely to use image guidance than for surgeries for non-polyp CRS [58]. Reporting of primary outcomes from sinus surgery is variable and relies on nasal endoscopy, radiographic findings, or self-reported symptom instruments such as the SNOT-22 survey.…”

Section: Role Of Surgerymentioning

confidence: 99%

The Role of Staphylococcus aureus in Patients with Chronic Sinusitis and Nasal Polyposis

Vickery

Ramakrishnan²,

Suh

2019

Curr Allergy Asthma Rep

Self Cite

View full text Add to dashboard Cite

Purpose of Review Staphylococcus aureus (S. aureus) is correlated with the development of persistent severe inflammatory disease of the upper airway including chronic rhinosinusitis with nasal polyps (CRSwNP). The presence of S. aureus is associated with atopic disease including allergic rhinitis and atopic dermatitis and is associated with poor outcomes. Recent Findings Several different strains of S. aureus generate different toxins and gene products that can account for organism pathogenicity. S. aureus bacteria and its antigens shape the bacterial and fungal microbiome and the mucosal niche which generates host responses that can account for inflammation. The multiple disease phenotypes and molecular endotypes seen in CRSwNP can be characterized by T-helper cell environment within the inflammatory milieu, the presence of epithelial barrier dysfunction, aberrant eicosanoid metabolism, poor wound healing, and dysfunctional host-bacteria interactions which lead to recalcitrant disease and worse surgical outcomes. Summary Understanding the pathomechanisms that S. aureus utilizes to promote nasal polyp formation, prolonged tissue inflammation, and bacterial dysbiosis are essential in our efforts to identify new therapeutic approaches to resolve this chronic inflammatory process.

show abstract

How Often is Sinus Surgery Performed for Chronic Rhinosinusitis with versus without Nasal Polyps?

Abstract: Background: There currently are no data on the relative frequency of endoscopic sinus surgeries (ESS)

Cited by 16 publications

References 33 publications

Predictive value of SNOT‐22 on additional opiate prescriptions after endoscopic sinus surgery

Predictive value of SNOT‐22 on additional opiate prescriptions after endoscopic sinus surgery

Systematic literature review of humanistic and economic burdens of chronic rhinosinusitis with nasal polyposis

The Role of Staphylococcus aureus in Patients with Chronic Sinusitis and Nasal Polyposis

Contact Info

Product

Resources

About