Epidemiological science and cancer control

Toporcov, Tatiana Natasha; Filho, Victor Wünsch

doi:10.6061/clinics/2018/e627s

Cited by 26 publications

(20 citation statements)

References 101 publications

(106 reference statements)

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“…The lung cancer mortality rates were significantly higher among men compared to women, but with decreasing trends among men and increasing trends among women, in Brazil. This finding is in agreement with previous www.nature.com/scientificreports/ studies conducted in the country 10,[22][23][24] .International studies assessing worldwide lung cancer trends across five continents have also found similar results 25,26 . The increase in disease mortality among women is partly attributable to an increase in tobacco use in recent decades 22 .…”

Section: Discussionsupporting

confidence: 92%

Inequalities in lung cancer mortality trends in Brazil, 2000–2015

Fernandes

Menezes

Silva

et al. 2020

Sci Rep

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The present study was conducted to evaluate the socioeconomic inequality related to lung cancer mortality rates and trends between 2000 and 2015 according to gender in Brazil. We retrieved the death records for cases of lung cancer (ICD-10 C33 C34) from 2000 to 2015 in adults age 30 years and older in Brazilian Regions from official databases (DATASUS) and corrected for ill-defined causes. The Prais-Winsten regression method and Pearson correlation were applied. The results were considered statistically significant when p < 0.05. The correlation between the lung cancer mortality rates and the HDI decreased when the rates for the first and last years of the historical series were compared in men (r = 0.77; r = 0.58) and women (r = 0.64; r = 0.41). However, the correlation between the trends in the lung cancer mortality rates and the HDI was negative in men (r = − 0.76) and women (r = − 0.58), indicating larger reductions (or smaller additions) among the Federative Units with the highest HDI, in contrast to trends reflecting a greater increase in those with the lowest HDI. Our results suggest a relevant inequality in the trends of mortality from lung cancer in Brazil.

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Section: Discussionsupporting

confidence: 92%

Inequalities in lung cancer mortality trends in Brazil, 2000–2015

Fernandes

Menezes

Silva

et al. 2020

Sci Rep

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“…Cancer poses a significant threat to the global health and is known as the second most common cause of death after cardiovascular diseases, owing to its high recurrence and mortality rates which have been estimated to be nearly 9.6 million deaths in 2018 [1].…”

Section: Introductionmentioning

confidence: 99%

Oncolytic paramyxoviruses-induced autophagy; a prudent weapon for cancer therapy

et al. 2019

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Oncolytic virotherapy has currently emerged as a promising approach upon which scientists have been able to induce tumor-specific cell death in a broad spectrum of malignancies. Paramyxoviruses represent intrinsic oncolytic capability, which makes them excellent candidates to be widely used in oncolytic virotherapy. The mechanisms through which these viruses destroy the cancerous cells involve triggering the autophagic machinery and apoptosis in target cells. Interestingly, oncolytic paramyxoviruses have been found to induce autophagy and lead to tumor cells death rather than their survival. Indeed, the induction of autophagy has been revealed to enhance the immunogenicity of tumor cells via the release of damage-associated molecular patterns (DAMPs) and the activation of autophagy-related immunogenic cell death (ICD). Subsequent cross-presentation of tumor-associated antigens (TAA) through the MHC-I complex to CD8+ T cells results in the productive priming of the tumor-specific immune response. In this review, we first briefly discuss autophagy and explain the process of viral xenophagy. Finally, we focus on the interactions between virus and autophagy proteins, elaborating on the global preclinical studies on oncolytic paramyxoviruses.

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“…Since the mid-1980s, several countries have banned the use of the fibre in their territories because of consistent epidemiological evidence of its health risks [15]. In November 2017, the Brazilian Supreme Court rendered a decision prohibiting the extraction, industrialization, and commercialization of asbestos throughout the Brazilian territory [16]. However, the decision will not be implemented until the industry appeals to the court are judged.…”

Section: Introductionmentioning

confidence: 99%

Lung Cancer Mortality Trends in a Brazilian City with a Long History of Asbestos Consumption

Fernandes

Algranti

Conceição

et al. 2019

IJERPH

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There are scarce epidemiological studies on lung cancer mortality in areas exposed to asbestos in developing countries. We compared the rates and trends in mortality from lung cancer between 1980 and 2016 in a municipality that made extensive use of asbestos, Osasco, with rates from a referent municipality with lower asbestos exposure and with the rates for the State of São Paulo. We retrieved death records for cases of lung cancer (ICD-9 C162) (ICD-10 C33 C34) from 1980 to 2016 in adults aged 60 years and older. The join point regression and age-period-cohort models were fitted to the data. Among men, there was an increasing trend in lung cancer mortality in Osasco of 0.7% (CI: 0.1; 1.3) in contrast to a mean annual decrease for Sorocaba of -1.5% (CI: −2.4; −0.6) and a stable average trend for São Paulo of -0.1 (IC: −0.3; 0.1). Similar increasing trends were seen in women. The age-period-cohort model showed an increase in the risk of death from 1996 in Osasco and a reduction for Sorocaba and São Paulo State during the same period. Our results point to a need for a special monitoring regarding lung cancer incidence and mortality in areas with higher asbestos exposure.

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Epidemiological science and cancer control

Cited by 26 publications

References 101 publications

Inequalities in lung cancer mortality trends in Brazil, 2000–2015

Inequalities in lung cancer mortality trends in Brazil, 2000–2015

Oncolytic paramyxoviruses-induced autophagy; a prudent weapon for cancer therapy

Lung Cancer Mortality Trends in a Brazilian City with a Long History of Asbestos Consumption

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